2003
Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk
Wu X, Yu H, Makan N, Spitz M. Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk. Methods In Molecular Medicine 2003, 75: 279-287. PMID: 12407747, DOI: 10.1385/1-59259-324-0:279.Peer-Reviewed Original ResearchMeSH Keywords7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideBleomycinChromatidsChromosome AberrationsEnzyme-Linked Immunosorbent AssayHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IILung NeoplasmsLymphocytesMutagenicity TestsMutagensPredictive Value of TestsRisk FactorsConceptsInsulin-like growth factorSignal transduction pathwaysGrowth factorCell cycle progressionCell membrane receptorsTransduction pathwaysBcl proteinsMAP kinaseLung cancer cellsIGF-1 receptorCell deathMembrane receptorsS phaseAntiproliferative moleculesBinding of IGFBax proteinCell proliferationLung cancer riskImportant functionsProteinCancer cellsCyclin D1Retinoic acidTypes of peptidesMitogenic action
2001
Free insulin‐like growth factor‐I and breast cancer risk
Li B, Khosravi M, Berkel H, Diamandi A, Dayton M, Smith M, Yu H. Free insulin‐like growth factor‐I and breast cancer risk. International Journal Of Cancer 2001, 91: 736-739. PMID: 11267989, DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1111>3.0.co;2-#.Peer-Reviewed Original ResearchConceptsIGF-I receptorInsulin-like growth factorFree IGFIGFBP-3Action of IGFBreast cancer patientsTotal IGFBreast cancer riskBreast cancerIGF-IICancer patientsPlasma levelsCancer riskFree insulin-like growth factorRace-matched healthy controlsFree IGF-I levelsConditional logistic regression analysisGrowth factorIGF-I levelsIGF binding proteinBinding of IGFHigher plasma levelsLogistic regression analysisHigher plasma IGFAnti-apoptotic effects