2014
Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer
Neale RE, Clark PJ, Fawcett J, Fritschi L, Nagler BN, Risch HA, Walters RJ, Crawford WJ, Webb PM, Whiteman DC, Buchanan DD. Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer. Cancer Epidemiology 2014, 38: 576-582. PMID: 25201440, DOI: 10.1016/j.canep.2014.08.006.Peer-Reviewed Original ResearchConceptsPancreatic cancerWhite blood cell DNABlood cell DNAOdds ratioPresence of metastasesCancer-related deathPancreatic cancer casesHealthy unrelated controlsEarly diseaseCell DNALeading causeCancer casesWBC DNADNA repetitive elementsBlood collectionCancerConfidence intervalsUnrelated controlsMethylation scoreFurther studiesAssociationMarkersDeathPCR assaysQuantitative PCR assays
2013
PPM1D Mutations in Circulating White Blood Cells and the Risk for Ovarian Cancer
Akbari MR, Lepage P, Rosen B, McLaughlin J, Risch H, Minden M, Narod SA. PPM1D Mutations in Circulating White Blood Cells and the Risk for Ovarian Cancer. Journal Of The National Cancer Institute 2013, 106: djt323. PMID: 24262437, DOI: 10.1093/jnci/djt323.Peer-Reviewed Original ResearchMeSH KeywordsAgedBRCA1 ProteinBRCA2 ProteinBreast NeoplasmsCanadaCase-Control StudiesFemaleGenetic Predisposition to DiseaseHeterozygoteHumansIncidenceLeukocytesMiddle AgedMutationOdds RatioOvarian NeoplasmsPhosphoprotein PhosphatasesProportional Hazards ModelsProtein Phosphatase 2CRisk AssessmentRisk FactorsConceptsCase patientsWhite blood cellsOvarian cancerControl subjectsOvarian cancer case patientsFemale first-degree relativesBlood cellsCancer case patientsFirst-degree relativesLifetime riskBreast cancerFamily historyMutation carriersPatientsCancerPast historyTruncating mutationsBreastRiskMutationsSubjectsCellsNoncarriersMortalityWomen