2007
GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas
Wideroff L, Vaughan TL, Farin FM, Gammon MD, Risch H, Stanford JL, Chow WH. GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas. Cancer Epidemiology 2007, 31: 233-236. PMID: 17646057, PMCID: PMC2268246, DOI: 10.1016/j.cdp.2007.03.004.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAllelesArylamine N-AcetyltransferaseCase-Control StudiesCytochrome P-450 CYP1A1Esophageal NeoplasmsFemaleGenetic Predisposition to DiseaseGlutathione S-Transferase piGlutathione TransferaseHumansIsoenzymesMaleMiddle AgedOdds RatioPolymerase Chain ReactionPolymorphism, GeneticRisk FactorsStomach NeoplasmsUnited StatesConceptsGastric adenocarcinomaOdds ratioGastric cardia adenocarcinomaEsophageal adenocarcinomaCardia adenocarcinomaElevated riskConfidence intervalsVal genotypePopulation-based case-control studyCYP1A1 Val/ValGSTP1 Val/Val genotypeNoncardia gastric adenocarcinomaEpidemiologic risk factorsRespective odds ratiosRisk of esophagealIle/Val genotypeVal/Val genotypeCase-control studyVal/ValN-acetyltransferase 1Same catchment areaHistologic subgroupsIncident casesRisk factorsGSTT1 genotype
2005
Glutathione S-transferase polymorphisms and ovarian cancer treatment and survival
Beeghly A, Katsaros D, Chen H, Fracchioli S, Zhang Y, Massobrio M, Risch H, Jones B, Yu H. Glutathione S-transferase polymorphisms and ovarian cancer treatment and survival. Gynecologic Oncology 2005, 100: 330-337. PMID: 16199080, DOI: 10.1016/j.ygyno.2005.08.035.Peer-Reviewed Original ResearchConceptsOvarian cancer treatmentDisease progressionGSTP1 genotypesGST polymorphismsPrimary epithelial ovarian cancerCox proportional hazards regressionFunctional polymorphismsGSTP1 Ile/IleCancer treatmentGSTP1 Ile/ValGlutathione S-transferase polymorphismsGSTM1 null patientsPost-operative chemotherapySubgroup of patientsProportional hazards regressionEpithelial ovarian cancerOvarian cancer survivalEffect of chemotherapyOvarian cancer prognosisOvarian cancer progressionVal/ValIle/IleIle/ValOverall survivalTumor characteristics