2017
A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA
Li N, Petrick JL, Steck SE, Bradshaw PT, McClain KM, Niehoff NM, Engel LS, Shaheen NJ, Risch HA, Vaughan TL, Wu AH, Gammon MD. A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA. International Journal Of Epidemiology 2017, 46: 1836-1846. PMID: 29040685, PMCID: PMC5837717, DOI: 10.1093/ije/dyx203.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedBlood GlucoseBody Mass IndexCase-Control StudiesDietary CarbohydratesDietary SucroseEsophageal NeoplasmsFemaleGastroesophageal RefluxHumansIncidenceLogistic ModelsMaleMiddle AgedMultivariate AnalysisNutrition AssessmentProportional Hazards ModelsRisk FactorsStomach NeoplasmsUnited StatesConceptsGastro-esophageal reflux diseaseBody mass indexCarbohydrate intakeAdenocarcinoma incidenceGCA incidenceOdds ratioUS population-based case-control studyStudy-specific food-frequency questionnairesPopulation-based case-control studyCox proportional hazards regressionGlycaemic indexDietary glycaemic indexFood frequency questionnaireProportional hazards regressionCase-control studyIntake of sucroseHigh glycaemic indexCarbohydrate measuresFrequency questionnaireHazard ratioReflux diseaseMass indexHazards regressionVital statusPooled analysis
2016
Nonsteroidal anti-inflammatory drugs, statins, and pancreatic cancer risk: a population-based case–control study
Kho PF, Fawcett J, Fritschi L, Risch H, Webb PM, Whiteman DC, Neale RE. Nonsteroidal anti-inflammatory drugs, statins, and pancreatic cancer risk: a population-based case–control study. Cancer Causes & Control 2016, 27: 1457-1464. PMID: 27817122, DOI: 10.1007/s10552-016-0824-4.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsUse of NSAIDsPopulation-based case-control studyCase-control studyAnti-inflammatory drugsPancreatic cancerProtective effectHistory of NSAIDsUnconditional multivariable logistic regressionSelective COX-2 inhibitorsMultivariable logistic regressionPancreatic cancer riskSex-matched controlsCOX-2 inhibitorsPancreatic cancer studiesStatin useMedication useSmoking statusCancer riskMedication sectionStatinsCancerLogistic regressionMore frequent usersCancer studiesAssociation between family cancer history and risk of pancreatic cancer
Schulte A, Pandeya N, Fawcett J, Fritschi L, Klein K, Risch HA, Webb PM, Whiteman DC, Neale RE. Association between family cancer history and risk of pancreatic cancer. Cancer Epidemiology 2016, 45: 145-150. PMID: 27810486, DOI: 10.1016/j.canep.2016.10.005.Peer-Reviewed Original ResearchConceptsPancreatic cancerFamily historyOdds ratioAustralian population-based case-control studyPopulation-based case-control studyLaird random-effects modelHistory of cancerAdjusted odds ratioPancreatic cancer patientsConfidence intervalsFamily cancer historyCase-control studyPancreatic cancer riskFirst-degree relativesRandom-effects modelMelanoma family historyPancreatic cancer studiesCancer historyCancer patientsRisk factorsPancreatic adenocarcinomaProstate cancerCancer riskMEDLINE databaseCancerAssociation Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk
Lee AW, Ness RB, Roman LD, Terry KL, Schildkraut JM, Chang-Claude J, Doherty JA, Menon U, Cramer DW, Gayther SA, Risch H, Gentry-Maharaj A, Goodman MT, Modugno F, Eilber U, Moysich KB, Berchuck A, Rossing MA, Jensen A, Wicklund KG, Cushing-Haugen KL, Hogdall E, Rudolph A, Thompson PJ, Wilkens LR, Kjaer SK, Carney ME, Stram DO, Ramus SJ, Wu AH, Pike MC, Pearce CL. Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk. Obstetrics And Gynecology 2016, 127: 828-836. PMID: 27054934, PMCID: PMC4892111, DOI: 10.1097/aog.0000000000001387.Peer-Reviewed Original ResearchConceptsEndometrioid ovarian carcinomaTherapy useOvarian carcinomaPostmenopausal estrogenControl groupPopulation-based case-control studyCase-control studyOvarian carcinoma histotypesOvarian carcinoma riskConditional logistic regressionOvarian Cancer Association ConsortiumSerous ovarian carcinomaDuration of useTiming of useTherapy usersMenopausal estrogensPooled analysisRisk factorsSelf-reported questionnaire dataCarcinoma riskCarcinomaEstrogenRecent usersLogistic regressionHistotype
2015
Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis
Schulte A, Pandeya N, Fawcett J, Fritschi L, Risch HA, Webb PM, Whiteman DC, Neale RE. Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis. Cancer Causes & Control 2015, 26: 1027-1035. PMID: 25951801, DOI: 10.1007/s10552-015-0595-3.Peer-Reviewed Original ResearchConceptsH. pylori seropositivityPancreatic cancer riskPylori seropositivityPancreatic cancerOdds ratioCancer riskAustralian population-based case-control studyConfidence intervalsH. pyloriPopulation-based case-control studyHelicobacter pyloriOverall associationStrain-specific associationsLaird random-effects modelAdjusted odds ratioCase-control studyCytotoxin-associated geneSignificant overall associationRandom-effects modelEnzyme-linked immunosorbentPancreatic cancer studiesCagA seropositivityMethodsBlood samplesEpidemiological studiesSeropositivityOccupational exposure to N-nitrosamines and pesticides and risk of pancreatic cancer
Fritschi L, Benke G, Risch HA, Schulte A, Webb PM, Whiteman DC, Fawcett J, Neale RE. Occupational exposure to N-nitrosamines and pesticides and risk of pancreatic cancer. Occupational And Environmental Medicine 2015, 72: 678. PMID: 25780030, DOI: 10.1136/oemed-2014-102522.Peer-Reviewed Original ResearchConceptsCase-control studyOccupational exposurePancreatic cancerPopulation-based case-control studyLarge case-control studyLifetime job historiesPancreatic cancer developmentCigarette smokingLifestyle factorsFrequency of exposureLikelihood of exposureAnimal evidenceIncrease riskPancreatic carcinogenCancer developmentN-nitrosaminesOccupational hygienistsCancerSuch exposureJob historyRiskExposureAssociationSmokingSpecific questionsUrinary Prostaglandin E2 Metabolite and Pancreatic Cancer Risk: Case-Control Study in Urban Shanghai
Zhao J, Wang J, Du J, Xu H, Zhang W, Ni QX, Yu H, Risch HA, Gao YT, Gao Y. Urinary Prostaglandin E2 Metabolite and Pancreatic Cancer Risk: Case-Control Study in Urban Shanghai. PLOS ONE 2015, 10: e0118004. PMID: 25679523, PMCID: PMC4332509, DOI: 10.1371/journal.pone.0118004.Peer-Reviewed Original ResearchConceptsCase-control studyPancreatic cancer riskPancreatic cancerOdds ratioCancer riskRecent population-based case-control studiesPopulation-based case-control studyUrinary PGE-M levelsUrinary prostaglandin E2 metabolitePGE-M levelsProstaglandin E2 metaboliteProstaglandin E2 metabolite levelsHigh meat intakePancreatic ductal adenocarcinoma casesUnconditional logistic regressionCOX-2 pathwayConfidence intervalsPancreatic ductal adenocarcinomaUrinary PGEDiabetes historyThird tertileE2 metaboliteDuctal adenocarcinomaMeat intakeAdenocarcinoma cases
2014
Aspirin, Nonaspirin Nonsteroidal Anti-inflammatory Drug, and Acetaminophen Use and Risk of Invasive Epithelial Ovarian Cancer: A Pooled Analysis in the Ovarian Cancer Association Consortium
Trabert B, Ness RB, Lo-Ciganic WH, Murphy MA, Goode EL, Poole EM, Brinton LA, Webb PM, Nagle CM, Jordan SJ, Group T, Risch H, Rossing M, Doherty J, Goodman M, Lurie G, Kjær S, Hogdall E, Jensen A, Cramer D, Terry K, Vitonis A, Bandera E, Olson S, King M, Chandran U, Anton-Culver H, Ziogas A, Menon U, Gayther S, Ramus S, Gentry-Maharaj A, Wu A, Pearce C, Pike M, Berchuck A, Schildkraut J, Wentzensen N, Consortium O. Aspirin, Nonaspirin Nonsteroidal Anti-inflammatory Drug, and Acetaminophen Use and Risk of Invasive Epithelial Ovarian Cancer: A Pooled Analysis in the Ovarian Cancer Association Consortium. Journal Of The National Cancer Institute 2014, 106: djt431. PMID: 24503200, PMCID: PMC3924755, DOI: 10.1093/jnci/djt431.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAnti-Inflammatory Agents, Non-SteroidalAnticarcinogenic AgentsAspirinAustraliaCarcinoma, Ovarian EpithelialCase-Control StudiesData CollectionDenmarkDrug Administration ScheduleFemaleHumansIncidenceLogistic ModelsNeoplasms, Glandular and EpithelialOdds RatioOvarian NeoplasmsProtective AgentsRiskUnited KingdomUnited StatesConceptsNonaspirin nonsteroidal anti-inflammatory drugsNonaspirin NSAIDsInvasive epithelial ovarian cancerNonsteroidal anti-inflammatory drugsLow-dose aspirinEpithelial ovarian cancerOvarian cancerAnti-inflammatory drugsAspirin useAcetaminophen useOdds ratioPopulation-based case-control studyDaily aspirin usersRegular aspirin useOvarian cancer riskCase-control studyOvarian Cancer Association ConsortiumHigh-dose usageDose of useAspirin regimenAnalgesic useAspirin usersCardiovascular eventsDose aspirinCase patientsCigarette smoking and pancreatic cancer risk: More to the story than just pack-years
Schulte A, Pandeya N, Tran B, Fawcett J, Fritschi L, Risch HA, Webb PM, Whiteman DC, Neale RE, Group Q. Cigarette smoking and pancreatic cancer risk: More to the story than just pack-years. European Journal Of Cancer 2014, 50: 997-1003. PMID: 24461200, DOI: 10.1016/j.ejca.2013.12.014.Peer-Reviewed Original ResearchConceptsPancreatic cancer riskCigarette smokingOdds ratioPancreatic adenocarcinomaCancer riskAustralian population-based case-control studyPopulation-based case-control studyLogistic regressionPancreatic cancer patientsConfidence intervalsCase-control studyPancreatic cancer studiesCurrent smokersAlcohol intakeSmoking patternsCancer patientsPancreatic cancerRisk factorsSmoking componentSmokingDisease riskRisk estimatesCancer studiesSmokersAdenocarcinomaA New Estimation Approach for Combining Epidemiological Data From Multiple Sources
Huang H, Ma X, Waagepetersen R, Holford TR, Wang R, Risch H, Mueller L, Guan Y. A New Estimation Approach for Combining Epidemiological Data From Multiple Sources. Journal Of The American Statistical Association 2014, 109: 11-23. PMID: 24683281, PMCID: PMC3964681, DOI: 10.1080/01621459.2013.870904.Peer-Reviewed Original ResearchEpidemiological dataPopulation-based case-control studyBehavioral Risk Factor Surveillance SystemRisk Factor Surveillance SystemConnecticut Tumor RegistryCase-control studyPancreatic cancer riskGroup of controlsGroup of casesTumor RegistryRisk factorsHealth SurveyCancer riskCertain diseasesSurveillance systemHelicobacter pylori Seropositivities and Risk of Pancreatic Carcinoma
Risch HA, Lu L, Kidd MS, Wang J, Zhang W, Ni Q, Gao YT, Yu H. Helicobacter pylori Seropositivities and Risk of Pancreatic Carcinoma. Cancer Epidemiology Biomarkers & Prevention 2014, 23: 172-178. PMID: 24234587, PMCID: PMC3947155, DOI: 10.1158/1055-9965.epi-13-0447.Peer-Reviewed Original ResearchConceptsCagA-positive strainsPancreatic cancerPancreatic carcinomaCagA seropositivityPylori seropositivityPylori colonizationGastric acidityH. pyloriLarge population-based case-control studyPopulation-based case-control studyPancreas cancer riskParticular cancer siteVirulence protein CagAHelicobacter pylori seropositivityH. pylori seropositivityBody mass indexH. pylori colonizationCase-control studyHelicobacter pylori colonizationH. pylori CagAStrain typesPathophysiologic actionsVenipuncture specimensAntibody seropositivityCase patients
2013
Diet and lifestyle factors and risk of subtypes of esophageal and gastric cancers: classification tree analysis
Silvera S, Mayne ST, Gammon MD, Vaughan TL, Chow WH, Dubin JA, Dubrow R, Stanford JL, West AB, Rotterdam H, Blot WJ, Risch HA. Diet and lifestyle factors and risk of subtypes of esophageal and gastric cancers: classification tree analysis. Annals Of Epidemiology 2013, 24: 50-57. PMID: 24239095, PMCID: PMC4006990, DOI: 10.1016/j.annepidem.2013.10.009.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Squamous CellCase-Control StudiesConnecticutDietEsophageal NeoplasmsFeeding BehaviorFemaleGastroesophageal RefluxHumansIncidenceLife StyleLogistic ModelsMaleMiddle AgedNew JerseyRisk FactorsStatistics as TopicStomach NeoplasmsSurveys and QuestionnairesWashingtonYoung AdultConceptsImportant risk stratification factorRisk stratification factorsSquamous cell carcinomaRisk of subtypesGastric cardiaRisk factorsCell carcinomaGastric cancerStratification factorsPopulation-based case-control studyGastroesophageal reflux disease symptomsEsophageal squamous cell carcinomaGastroesophageal reflux diseaseCase-control studyInteraction of dietReflux diseaseLifestyle factorsWine intakeDietary factorsCancer sitesMedical factorsGastric sitesNoncitrus fruitClassification tree analysisCancer subtypesGenital Powder Use and Risk of Ovarian Cancer: A Pooled Analysis of 8,525 Cases and 9,859 Controls
Terry KL, Karageorgi S, Shvetsov YB, Merritt MA, Lurie G, Thompson PJ, Carney ME, Weber RP, Akushevich L, Lo-Ciganic WH, Cushing-Haugen K, Sieh W, Moysich K, Doherty JA, Nagle CM, Berchuck A, Pearce CL, Pike M, Ness RB, Webb PM, Study A, Rossing M, Schildkraut J, Risch H, Goodman M. Genital Powder Use and Risk of Ovarian Cancer: A Pooled Analysis of 8,525 Cases and 9,859 Controls. Cancer Prevention Research 2013, 6: 811-821. PMID: 23761272, PMCID: PMC3766843, DOI: 10.1158/1940-6207.capr-13-0037.Peer-Reviewed Original ResearchConceptsEpithelial ovarian cancerOvarian cancerPowder usePopulation-based case-control studyMost histologic subtypesEpithelial ovarian cancer riskBorderline serous tumorsOvarian cancer riskCase-control studySubtype-specific riskConditional logistic regressionHistologic subtypeHistologic typeSerous tumorsPotential confoundersPooled analysisPooled ORsModifiable exposuresCancer riskTumor behaviorEpidemiologic investigationsCancerLogistic regressionLifetime numberCarcinogenic effectsDietary Energy Density Is Positively Associated with Risk of Pancreatic Cancer in Urban Shanghai Chinese 1,2
Wang J, Zhang W, Sun L, Yu H, Ni QX, Risch HA, Gao YT. Dietary Energy Density Is Positively Associated with Risk of Pancreatic Cancer in Urban Shanghai Chinese 1,2. Journal Of Nutrition 2013, 143: 1626-1629. PMID: 23902959, PMCID: PMC3771813, DOI: 10.3945/jn.113.178129.Peer-Reviewed Original ResearchConceptsCase-control studyPancreatic cancerDietary energy densityRisk factorsPopulation-based case-control studyFood frequency questionnaire dataIndependent risk factorPancreatic cancer riskType 2 diabetesAdjusted analysisProspective studyHighest quintileLowest quintileCancer riskNormal controlsRegular consumptionCancerOverall dietRiskQuintileShanghai ChineseUrban ShanghaiQuestionnaire dataObesityDiabetesRe-evaluation of ABO gene polymorphisms detected in a genome-wide association study and risk of pancreatic ductal adenocarcinoma in a Chinese population
Xu HL, Cheng JR, Zhang W, Wang J, Yu H, Ni QX, Risch HA, Gao YT. Re-evaluation of ABO gene polymorphisms detected in a genome-wide association study and risk of pancreatic ductal adenocarcinoma in a Chinese population. Cancer Communications 2013, 33: 68-73. PMID: 23816557, PMCID: PMC3884064, DOI: 10.5732/cjc.013.10060.Peer-Reviewed Original ResearchConceptsRisk of PDACPancreatic ductal adenocarcinomaCancer riskDuctal adenocarcinomaPopulation-based case-control studyChinese populationCase-control studyPancreatic cancer riskSignificant gene-environment interactionElevated cancer riskFatal malignancyPancreatic cancerTT carriersHealthy controlsGene-environment interactionsGene polymorphismsT alleleC alleleABO variantsWide association studyAssociation studiesMultifactor dimensionality reduction methodAdenocarcinomaRiskABO allelesTubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies
Sieh W, Salvador S, McGuire V, Weber RP, Terry KL, Rossing MA, Risch H, Wu AH, Webb PM, Moysich K, Doherty JA, Felberg A, Miller D, Jordan SJ, Study A, Group A, Goodman M, Lurie G, Chang-Claude J, Rudolph A, Kjær S, Jensen A, Høgdall E, Bandera E, Olson S, King M, Rodriguez-Rodriguez L, Kiemeney L, Marees T, Massuger L, van Altena A, Ness R, Cramer D, Pike M, Pearce C, Berchuck A, Schildkraut J, Whittemore A. Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies. International Journal Of Epidemiology 2013, 42: 579-589. PMID: 23569193, PMCID: PMC3619957, DOI: 10.1093/ije/dyt042.Peer-Reviewed Original ResearchConceptsOvarian cancer subtypesCase-control studyTubal ligationCancer subtypesHistological typeOvarian cancerClear cellsProtective effectPopulation-based case-control studyFull-term birthOvarian cancer riskPooled odds ratioConditional logistic regressionRace/ethnicitySerous cancerMucinous tumorsBorderline tumorsControl womenHistological subtypesInvasive casesPooled analysisOdds ratioCancer riskDistinct etiologiesInternational collaborative study
2012
Green tea drinking and risk of pancreatic cancer: A large-scale, population-based case–control study in urban Shanghai
Wang J, Zhang W, Sun L, Yu H, Ni QX, Risch HA, Gao YT. Green tea drinking and risk of pancreatic cancer: A large-scale, population-based case–control study in urban Shanghai. Cancer Epidemiology 2012, 36: e354-e358. PMID: 22944495, PMCID: PMC3490023, DOI: 10.1016/j.canep.2012.08.004.Peer-Reviewed Original ResearchConceptsPancreatic cancer riskGreen tea drinkingPopulation-based case-control studyCase-control studyPancreatic cancerCancer riskTea drinkingTea consumptionRegular tea drinkingRegular tea drinkersTea drinking habitsUrban ShanghaiHealthy controlsReduced riskEpidemiological studiesTea drinkersRegular drinkingDrinking habitsCancerInterview questionnaireLonger durationTea temperatureWomenDrinkingRiskOmega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case–control study
Arem H, Neuhouser ML, Irwin ML, Cartmel B, Lu L, Risch H, Mayne ST, Yu H. Omega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case–control study. European Journal Of Nutrition 2012, 52: 1251-1260. PMID: 22915050, PMCID: PMC3548981, DOI: 10.1007/s00394-012-0436-z.Peer-Reviewed Original ResearchConceptsEndometrial cancer riskFatty acid intakeCancer riskEndometrial cancerAcid intakeDietary intakePopulation-based case-control studyFish oil supplement useUnconditional logistic regression methodsLong-chain omega-3 fatty acidsOmega-3 fatty acidsIncident cancer casesCase-control studyAge-matched controlsFatty acidsPopulation-based sampleTotal fish intakeSupplement useFish intakeExtreme quartilesProtective associationCancer casesHigh intakeReduced riskFatty acids EPA
2011
Long‐term overweight and weight gain in early adulthood in association with risk of endometrial cancer
Lu L, Risch H, Irwin ML, Mayne ST, Cartmel B, Schwartz P, Rutherford T, Yu H. Long‐term overweight and weight gain in early adulthood in association with risk of endometrial cancer. International Journal Of Cancer 2011, 129: 1237-1243. PMID: 21387312, PMCID: PMC3125463, DOI: 10.1002/ijc.26046.Peer-Reviewed Original ResearchConceptsBody mass indexLong-term overweightEndometrial cancerSubstantial weight gainWeight gainBody weightPopulation-based case-control studyHigher body mass indexEndometrial cancer riskWeight changeDisease 10 yearsEarly adulthoodUnconditional logistic regressionAdult lifeCase-control studyTime of interviewSuch weight changesMass indexNormal weightIncident casesRisk factorsOdds ratioLong-term effectsAge 40Cancer riskPrincipal Component Analysis of Dietary and Lifestyle Patterns in Relation to Risk of Subtypes of Esophageal and Gastric Cancer
Silvera S, Mayne ST, Risch HA, Gammon MD, Vaughan T, Chow WH, Dubin JA, Dubrow R, Schoenberg J, Stanford JL, West AB, Rotterdam H, Blot WJ. Principal Component Analysis of Dietary and Lifestyle Patterns in Relation to Risk of Subtypes of Esophageal and Gastric Cancer. Annals Of Epidemiology 2011, 21: 543-550. PMID: 21435900, PMCID: PMC3109225, DOI: 10.1016/j.annepidem.2010.11.019.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedBody Mass IndexCase-Control StudiesConnecticutDietEsophageal NeoplasmsFemaleGastroesophageal RefluxHealth BehaviorHumansLife StyleLogistic ModelsMaleMiddle AgedNeoplasms, Squamous CellNew JerseyPrincipal Component AnalysisRegistriesRisk FactorsStomach NeoplasmsSurveys and QuestionnairesWashingtonConceptsEsophageal squamous cell carcinomaGastric cardia adenocarcinomaRisk of EACSmoking/alcoholGastroesophageal reflux diseaseEsophageal adenocarcinomaRisk factorsGastric cancerPopulation-based case-control studyRisk of ESCCFruit/vegetable intakeLifestyle patternsSquamous cell carcinomaRisk of subtypesCase-control studyFruits/vegetablesReflux diseaseLifestyle factorsVegetable scoresCell carcinomaVegetable intakeNitrite intakeAlcohol scoresCancer casesCancer risk