2013
Re-evaluation of ABO gene polymorphisms detected in a genome-wide association study and risk of pancreatic ductal adenocarcinoma in a Chinese population
Xu HL, Cheng JR, Zhang W, Wang J, Yu H, Ni QX, Risch HA, Gao YT. Re-evaluation of ABO gene polymorphisms detected in a genome-wide association study and risk of pancreatic ductal adenocarcinoma in a Chinese population. Cancer Communications 2013, 33: 68-73. PMID: 23816557, PMCID: PMC3884064, DOI: 10.5732/cjc.013.10060.Peer-Reviewed Original ResearchConceptsRisk of PDACPancreatic ductal adenocarcinomaCancer riskDuctal adenocarcinomaPopulation-based case-control studyChinese populationCase-control studyPancreatic cancer riskSignificant gene-environment interactionElevated cancer riskFatal malignancyPancreatic cancerTT carriersHealthy controlsGene-environment interactionsGene polymorphismsT alleleC alleleABO variantsWide association studyAssociation studiesMultifactor dimensionality reduction methodAdenocarcinomaRiskABO allelesPolymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4
Leenders M, Bhattacharjee S, Vineis P, Stevens V, Bueno-de-Mesquita HB, Shu XO, Amundadottir L, Gross M, Tobias GS, Wactawski-Wende J, Arslan AA, Duell EJ, Fuchs CS, Gallinger S, Hartge P, Hoover RN, Holly EA, Jacobs EJ, Klein AP, Kooperberg C, LaCroix A, Li D, Mandelson MT, Olson SH, Petersen G, Risch HA, Yu K, Wolpin BM, Zheng W, Agalliu I, Albanes D, Boutron-Ruault MC, Bracci PM, Buring JE, Canzian F, Chang K, Chanock SJ, Cotterchio M, Gaziano JM, Giovanucci EL, Goggins M, Hallmans G, Hankinson SE, Hoffman-Bolton JA, Hunter DJ, Hutchinson A, Jacobs KB, Jenab M, Khaw KT, Kraft P, Krogh V, Kurtz RC, McWilliams RR, Mendelsohn JB, Patel AV, Rabe KG, Riboli E, Tjønneland A, Trichopoulos D, Virtamo J, Visvanathan K, Elena JW, Yu H, Zeleniuch-Jacquotte A, Stolzenberg-Solomon RZ. Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4. Cancer Causes & Control 2013, 24: 595-602. PMID: 23334854, PMCID: PMC4127987, DOI: 10.1007/s10552-012-0138-0.Peer-Reviewed Original ResearchConceptsCase-control studyOne-carbon metabolismSingle nucleotide polymorphismsPancreatic cancerOne-carbon biomarkersEuropean Prospective InvestigationCorrelation of SNPsProspective InvestigationFolate intakePancreatic carcinogenesisLarge genetic studiesGene polymorphismsSignificant associationPANCACancerMetabolite levelsGermline variationP-valueMultiple comparisonsAssociationSuggestive associationPolymorphismSuggestive evidenceMetabolismOCM pathway
2006
PGR +331 A/G and Increased Risk of Epithelial Ovarian Cancer
Risch HA, Bale AE, Beck PA, Zheng W. PGR +331 A/G and Increased Risk of Epithelial Ovarian Cancer. Cancer Epidemiology Biomarkers & Prevention 2006, 15: 1738-1741. PMID: 16985038, DOI: 10.1158/1055-9965.epi-06-0272.Peer-Reviewed Original ResearchConceptsOvarian cancerA allelePostmenopausal womenProgesterone receptor gene polymorphismHistologic tumor typePopulation-based studyEpithelial ovarian cancerEffect of progesteroneReceptor gene polymorphismsPremenopausal womenEndometrial cancerMenopausal statusOral contraceptivesOvarian neoplasiaProgesterone receptorProgestin exposureG genotypeGG genotypeGene polymorphismsTumor typesReceptor isoformsCancerWomenRiskProgesterone
2003
Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, Stanford JL, Mayne ST, Goedert J, Blot WJ, Fraumeni JF, Chow WH. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003, 124: 1193-1201. PMID: 12730860, DOI: 10.1016/s0016-5085(03)00157-4.Peer-Reviewed Original ResearchConceptsProinflammatory cytokine gene polymorphismsNoncardia gastric cancerUpper gastrointestinal cancerCytokine gene polymorphismsGastric cancerIL-10Gastrointestinal cancerReceptor antagonistGene polymorphismsPopulation-based case-control studyCytokine genesTumor necrosis factor AAnti-inflammatory cytokine genesIL-1 receptor antagonistGastric H. pylori infectionEsophageal squamous cell carcinomaHelicobacter pylori-related gastric cancerTumor necrosis factor alphaNoncardia gastric adenocarcinomaIL-1 gene clusterFrequency-matched controlsSquamous cell carcinomaH. pylori infectionGastric cardia cancerCase-control study