2018
Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus
Dong J, Levine DM, Buas MF, Zhang R, Onstad L, Fitzgerald RC, Consortium S, Corley DA, Shaheen NJ, Lagergren J, Hardie LJ, Reid BJ, Iyer PG, Risch HA, Caldas C, Caldas I, Pharoah PD, Liu G, Gammon MD, Chow WH, Bernstein L, Bird NC, Ye W, Wu AH, Anderson LA, MacGregor S, Whiteman DC, Vaughan TL, Thrift AP. Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus. Clinical Gastroenterology And Hepatology 2018, 16: 1598-1606.e4. PMID: 29551738, PMCID: PMC6162842, DOI: 10.1016/j.cgh.2018.03.007.Peer-Reviewed Original ResearchConceptsRisk of EACGastroesophageal reflux diseaseBarrett's esophagusEsophageal adenocarcinomaGERD symptomsWide association studySmoking statusSymptoms of GERDChromosome 1p34.3Environmental factorsChromosome 2p25.1Association of BMIChromosome 1Borderline significant interactionAssociation studiesGene studiesOesophageal cancer studiesSusceptibility lociCase-control logistic regressionGenesChromosome 15q14Genetic variantsReflux diseaseSmoking historyBMI measurements
2017
Determining Risk of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants
Dong J, Buas MF, Gharahkhani P, Kendall BJ, Onstad L, Zhao S, Anderson LA, Wu AH, Ye W, Bird NC, Bernstein L, Chow WH, Gammon MD, Liu G, Caldas C, Pharoah PD, Risch HA, Iyer PG, Reid BJ, Hardie LJ, Lagergren J, Shaheen NJ, Corley DA, Fitzgerald RC, consortium S, Whiteman DC, Vaughan TL, Thrift AP. Determining Risk of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants. Gastroenterology 2017, 154: 1273-1281.e3. PMID: 29247777, PMCID: PMC5880715, DOI: 10.1053/j.gastro.2017.12.003.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaArea Under CurveAustraliaBarrett EsophagusCase-Control StudiesDatabases, FactualDecision Support TechniquesEsophageal NeoplasmsEuropeFemaleGene-Environment InteractionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLife StyleLogistic ModelsMaleMiddle AgedModels, GeneticMolecular EpidemiologyMultifactorial InheritanceNorth AmericaOdds RatioPhenotypePolymorphism, Single NucleotidePredictive Value of TestsRisk AssessmentRisk FactorsROC CurveConceptsGastroesophageal reflux diseaseBarrett's esophagusEsophageal adenocarcinomaLifestyle factorsPolygenic risk scoresGERD symptomsNon-genetic factorsDemographic/lifestyle factorsNet reclassification improvementCharacteristic curve analysisAUC valuesRisk prediction modelEsophageal cancer studyInternational Barrett'sReflux diseaseHighest quartileNet reclassificationEpidemiologic factorsReclassification improvementLowest quartileHigh riskRisk scorePatientsEsophagusAbstractText
2015
A Newly Identified Susceptibility Locus near FOXP1 Modifies the Association of Gastroesophageal Reflux with Barrett's Esophagus
Dai JY, de Dieu Tapsoba J, Buas MF, Onstad LE, Levine DM, Risch HA, Chow WH, Bernstein L, Ye W, Lagergren J, Bird NC, Corley DA, Shaheen NJ, Wu AH, Reid BJ, Hardie LJ, Whiteman DC, Vaughan TL. A Newly Identified Susceptibility Locus near FOXP1 Modifies the Association of Gastroesophageal Reflux with Barrett's Esophagus. Cancer Epidemiology Biomarkers & Prevention 2015, 24: 1739-1747. PMID: 26377193, PMCID: PMC4816532, DOI: 10.1158/1055-9965.epi-15-0507.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBarrett EsophagusCase-Control StudiesEsophageal NeoplasmsFemaleForkhead Transcription FactorsGastroesophageal RefluxGenetic LociGenetic MarkersGenetic Predisposition to DiseaseGenome-Wide Association StudyHomozygoteHumansMalePolymorphism, Single NucleotideRepressor ProteinsRisk FactorsConceptsBody mass indexBarrett's esophagusEsophageal adenocarcinomaWeekly heartburnCase patientsSmoking statusMass indexRisk factorsSingle nucleotide polymorphismsMinor alleleBarrett's esophagus riskGene-exposure interactionsLeast weekly heartburnGastroesophageal reflux diseaseImportant risk factorGermline single nucleotide polymorphismsLogistic regression modelsExposure-disease associationsReflux symptomsGastroesophageal refluxReflux diseaseCigarette smokingSusceptibility single nucleotide polymorphismsOdds ratioEsophagus
2013
Diet and lifestyle factors and risk of subtypes of esophageal and gastric cancers: classification tree analysis
Silvera S, Mayne ST, Gammon MD, Vaughan TL, Chow WH, Dubin JA, Dubrow R, Stanford JL, West AB, Rotterdam H, Blot WJ, Risch HA. Diet and lifestyle factors and risk of subtypes of esophageal and gastric cancers: classification tree analysis. Annals Of Epidemiology 2013, 24: 50-57. PMID: 24239095, PMCID: PMC4006990, DOI: 10.1016/j.annepidem.2013.10.009.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Squamous CellCase-Control StudiesConnecticutDietEsophageal NeoplasmsFeeding BehaviorFemaleGastroesophageal RefluxHumansIncidenceLife StyleLogistic ModelsMaleMiddle AgedNew JerseyRisk FactorsStatistics as TopicStomach NeoplasmsSurveys and QuestionnairesWashingtonYoung AdultConceptsImportant risk stratification factorRisk stratification factorsSquamous cell carcinomaRisk of subtypesGastric cardiaRisk factorsCell carcinomaGastric cancerStratification factorsPopulation-based case-control studyGastroesophageal reflux disease symptomsEsophageal squamous cell carcinomaGastroesophageal reflux diseaseCase-control studyInteraction of dietReflux diseaseLifestyle factorsWine intakeDietary factorsCancer sitesMedical factorsGastric sitesNoncitrus fruitClassification tree analysisCancer subtypes
2011
Principal Component Analysis of Dietary and Lifestyle Patterns in Relation to Risk of Subtypes of Esophageal and Gastric Cancer
Silvera S, Mayne ST, Risch HA, Gammon MD, Vaughan T, Chow WH, Dubin JA, Dubrow R, Schoenberg J, Stanford JL, West AB, Rotterdam H, Blot WJ. Principal Component Analysis of Dietary and Lifestyle Patterns in Relation to Risk of Subtypes of Esophageal and Gastric Cancer. Annals Of Epidemiology 2011, 21: 543-550. PMID: 21435900, PMCID: PMC3109225, DOI: 10.1016/j.annepidem.2010.11.019.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedBody Mass IndexCase-Control StudiesConnecticutDietEsophageal NeoplasmsFemaleGastroesophageal RefluxHealth BehaviorHumansLife StyleLogistic ModelsMaleMiddle AgedNeoplasms, Squamous CellNew JerseyPrincipal Component AnalysisRegistriesRisk FactorsStomach NeoplasmsSurveys and QuestionnairesWashingtonConceptsEsophageal squamous cell carcinomaGastric cardia adenocarcinomaRisk of EACSmoking/alcoholGastroesophageal reflux diseaseEsophageal adenocarcinomaRisk factorsGastric cancerPopulation-based case-control studyRisk of ESCCFruit/vegetable intakeLifestyle patternsSquamous cell carcinomaRisk of subtypesCase-control studyFruits/vegetablesReflux diseaseLifestyle factorsVegetable scoresCell carcinomaVegetable intakeNitrite intakeAlcohol scoresCancer casesCancer risk
2008
Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression
Figueroa JD, Terry MB, Gammon MD, Vaughan TL, Risch HA, Zhang FF, Kleiner DE, Bennett WP, Howe CL, Dubrow R, Mayne ST, Fraumeni JF, Chow WH. Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression. Cancer Causes & Control 2008, 20: 361-368. PMID: 18989634, PMCID: PMC2726999, DOI: 10.1007/s10552-008-9250-6.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAnti-Inflammatory Agents, Non-SteroidalBody Mass IndexCarcinoma, Squamous CellCardiaCase-Control StudiesConfidence IntervalsEsophageal NeoplasmsGastroesophageal RefluxHumansImmunohistochemistryLogistic ModelsMiddle AgedMulticenter Studies as TopicOdds RatioPopulation SurveillanceRisk FactorsSmokingStomach NeoplasmsTumor Suppressor Protein p53United StatesConceptsBody mass indexNon-steroidal anti-inflammatory drugsGastroesophageal reflux diseaseRisk factorsP53 overexpressionGastric cancerCigarette smokingReflux diseaseMass indexNon-steroidal anti-inflammatory drug useTumor subtypesPopulation-based case-control studyAnti-inflammatory drug useNon-cardia gastric adenocarcinomaGastro-esophageal reflux diseaseLarger body mass indexNon-cardia gastric cancerEsophageal squamous cell carcinomaTumor p53 overexpressionRisk factor profileSquamous cell carcinomaRisk of subtypesCase-control studyAnti-inflammatory drugsP53 protein overexpression
2007
Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma
Vaninetti NM, Geldenhuys L, Porter GA, Risch H, Hainaut P, Guernsey DL, Casson AG. Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma. Molecular Carcinogenesis 2007, 47: 275-285. PMID: 17849424, DOI: 10.1002/mc.20382.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseINOS mRNA expressionEsophageal adenocarcinomaNitric oxide synthaseP53 mutationsNitric oxideBarrett's esophagusOxide synthaseMRNA expressionEndogenous p53 mutationsGastroesophageal reflux diseaseActive inflammatory processPrimary esophageal adenocarcinomaPotential causative factorsReflux diseaseGastrointestinal malignanciesChronic inflammationINOS overexpressionEsophageal malignancyInflammatory processNormal epitheliumHuman premalignantEsophageal epitheliumMolecular pathogenesisSignificant association
2005
Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers
Trivers KF, de Roos AJ, Gammon MD, Vaughan TL, Risch HA, Olshan AF, Schoenberg JB, Mayne ST, Dubrow R, Stanford JL, Abrahamson P, Rotterdam H, West AB, Fraumeni JF, Chow WH. Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers. Clinical Gastroenterology And Hepatology 2005, 3: 225-230. PMID: 15765441, DOI: 10.1016/s1542-3565(04)00613-5.Peer-Reviewed Original ResearchConceptsBody mass indexEsophageal squamous cell carcinomaGastric cancerHazard ratioLonger survivalNonsteroidal anti-inflammatory drug usePopulation-based case-control studyAnti-inflammatory drug usePrediagnosis body mass indexAdjusted hazard ratioGastroesophageal reflux diseaseSquamous cell carcinomaConfidence intervalsGastric cancer survivalCase-control studyEsophageal adenocarcinoma patientsLocalized diseaseReflux diseaseMass indexAlcohol intakeCigarette smokingDecreased riskIncident casesAdenocarcinoma patientsCell carcinoma
2000
Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer
Farrow D, Vaughan T, Sweeney C, Gammon M, Chow W, Risch H, Stanford J, Hansten P, Mayne S, Schoenberg J, Rotterdam H, Ahsan H, West A, Dubrow R, Fraumeni J, Blot W. Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer. Cancer Causes & Control 2000, 11: 231-238. PMID: 10782657, DOI: 10.1023/a:1008913828105.Peer-Reviewed Original ResearchConceptsGastroesophageal reflux diseaseNon-cardia gastric adenocarcinomaEsophageal adenocarcinomaGERD symptomsReflux diseaseH2 blockersGastric adenocarcinomaGastric cancerLarge population-based case-control studyPopulation-based case-control studyPopulation-based tumor registryEsophageal squamous cell carcinomaPerson structured interviewRisk of esophagealSquamous cell carcinomaEsophageal adenocarcinoma riskH2-receptor antagonistsCase-control studyGastric cardia adenocarcinomaRandom digit dialingLong-term usersTumor RegistryAdenocarcinoma riskDaily symptomsCell carcinoma