2011
Socio-economic status, urbanization, and cardiometabolic risk factors among middle-aged adults in Tanzania.
Njelekela MA, Liu E, Mpembeni R, Muhihi A, Mligiliche N, Spiegelman D, Finkelstein JL, Fawzi WW, Willett WC, Mtabaji J. Socio-economic status, urbanization, and cardiometabolic risk factors among middle-aged adults in Tanzania. East African Journal Of Public Health 2011, 8: 216-23. PMID: 23120960.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood GlucoseBlood PressureBody Mass IndexCardiovascular DiseasesCross-Sectional StudiesDietExerciseFemaleHealth BehaviorHumansLife StyleLipidsLogistic ModelsMaleMetabolic SyndromeMiddle AgedObesityResidence CharacteristicsRisk FactorsSocioeconomic FactorsSurveys and QuestionnairesTanzaniaUrban HealthUrbanizationWaist CircumferenceConceptsCardiometabolic risk factorsPoorer lipid profileHigher socioeconomic statusRisk factorsLipid profileSocioeconomic statusUrban residenceCardio-metabolic risk factorsWorld Health Organization criteriaHigher total cholesterolHigh waist circumferenceRisk of obesityHealth screening strategiesMiddle-aged adultsMetabolic syndromeTotal cholesterolWaist circumferenceLDL cholesterolHigher BMIPrimary preventionLower triglyceridesOrganization criteriaDietary factorsCardiovascular diseaseGlucose levels
2005
Calculating deaths attributable to obesity.
Hu FB, Willett WC, Stampfer MJ, Spiegelman D, Colditz GA. Calculating deaths attributable to obesity. American Journal Of Public Health 2005, 95: 932; author reply 932-3. PMID: 15914810, PMCID: PMC1449281, DOI: 10.2105/ajph.2005.062836.Peer-Reviewed Original ResearchInfluence of Body Size and Body Fat Distribution on Risk of Uterine Leiomyomata in U.S. Black Women
Wise LA, Palmer JR, Spiegelman D, Harlow BL, Stewart EA, Adams-Campbell LL, Rosenberg L. Influence of Body Size and Body Fat Distribution on Risk of Uterine Leiomyomata in U.S. Black Women. Epidemiology 2005, 16: 346-354. PMID: 15824551, PMCID: PMC1847589, DOI: 10.1097/01.ede.0000158742.11877.99.Peer-Reviewed Original ResearchConceptsBody mass indexIncidence rate ratiosBlack Women's Health StudyWomen's Health StudyParous womenUterine leiomyomataHealth StudyWeight gainMultivariate incidence rate ratiosSelf-reported uterine leiomyomataU.S. prospective cohort studiesBlack womenProspective cohort studyBody fat distributionConfidence intervalsU.S. Black womenPremenopausal womenCohort studyPrior diagnosisHip ratioMass indexHip circumferenceFat distributionHealth QuestionnaireLarge cohort
2004
Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors
Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Marshall LM, Hunter DJ. Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors. American Journal Of Epidemiology 2004, 160: 784-796. PMID: 15466501, DOI: 10.1093/aje/kwh275.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAlcohol DrinkingAnthropometryBody ConstitutionBody Mass IndexDemographyEndometriosisFemaleFollow-Up StudiesHumansIncidenceInfertility, FemaleLaparoscopyLife StyleMiddle AgedMultivariate AnalysisNursesObesityPremenopauseProportional Hazards ModelsRisk FactorsSmokingStatistics, NonparametricUnited StatesWhite PeopleConceptsBody mass indexMass indexCigarette smokingLifestyle factorsNurses' Health Study II prospective cohortMultivariate Cox proportional hazards modelWaist/hip ratioCurrent body mass indexCox proportional hazards modelCurrent alcohol intakeCurrent cigarette smokingIncidence of endometriosisAge 18 yearsProportional hazards modelAfrican American womenPast infertilityLaparoscopic diagnosisProspective cohortAlcohol intakeHip ratioInfertility statusCaucasian womenIncidence rateCaffeine intakeHazards modelReproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study
Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-Campbell LL, Rosenberg L. Reproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study. American Journal Of Epidemiology 2004, 159: 113-123. PMID: 14718211, PMCID: PMC1847588, DOI: 10.1093/aje/kwh016.Peer-Reviewed Original ResearchConceptsUS black womenUterine leiomyomataHormonal contraceptionReproductive factorsSelf-reported uterine leiomyomataProspective cohort studyBody mass indexIncidence rate ratiosCox regression modelSelf-reported diagnosisBlack womenAfrican American womenReproductive covariatesCohort studyPremenopausal womenAlcohol intakeMass indexProspective studyInverse associationHormonal factorsLast birthLeiomyomataReproductive historyNew casesFirst birth
2003
A Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women
Kroenke CH, Chu NF, Rifai N, Spiegelman D, Hankinson SE, Manson JE, Rimm EB. A Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women. Diabetes Care 2003, 26: 1971-1978. PMID: 12832298, DOI: 10.2337/diacare.26.7.1971.Peer-Reviewed Original ResearchConceptsHealth Study IIGlycemic controlAlcohol intakeBiologic markersNurses' Health Study IIBeneficial glycemic effectsAverage alcohol intakeModerate alcohol consumptionMain outcome measuresCross-sectional studyYears of ageAlcohol consumption patternsOverweight womenGlycemic effectsInsulin levelsLifestyle factorsInsulin resistanceDietary factorsInverse associationC-peptideAverage daily consumptionOutcome measuresPhysical activityBlood samplesAlcohol consumption
2001
The correlates of dietary intake among HIV-positive adults 1 , 2 , 3
Kim J, Spiegelman D, Rimm E, Gorbach S. The correlates of dietary intake among HIV-positive adults 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 74: 852-861. PMID: 11722969, DOI: 10.1093/ajcn/74.6.852.Peer-Reviewed Original ResearchConceptsHigher energy intakeDietary intakeEnergy intakeHIV infectionClinical outcomesDietary adequacyAdverse clinical outcomesAbsence of nauseaInadequate dietary intakeInadequate protein intakeInadequate energy intakeInjection drug usersCross-sectional studyStudy cohortFemale sexDiet recordsReduced appetiteDietary inadequacyStudy populationProtein intakeDietary allowanceDrug usersDiverse cohortIntakeWeight lossRelationship of a large weight loss to long-term weight change among young and middle-aged US women
Field A, Wing R, Manson J, Spiegelman D, Willett W. Relationship of a large weight loss to long-term weight change among young and middle-aged US women. International Journal Of Obesity 2001, 25: 1113-1121. PMID: 11477495, DOI: 10.1038/sj.ijo.0801643.Peer-Reviewed Original ResearchConceptsHealth Study IIWeight lossPhysical activityNurses' Health Study IILong-term weight changeLong-term weight gainCategories of BMIBody mass indexLarge weight lossVigorous physical activityMiddle-aged womenSignificant weight lossSelf-reported weightDiagnosis of cancerMass indexWeight cyclingDietary intakeCardiovascular diseaseLess weightUS womenMost womenInactive peersBMIWeight gainStudy IIPlasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men
Chu N, Spiegelman D, Hotamisligil G, Rifai N, Stampfer M, Rimm E. Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis 2001, 157: 495-503. PMID: 11472752, DOI: 10.1016/s0021-9150(00)00755-3.Peer-Reviewed Original ResearchConceptsCVD risk factorsRisk factorsPlasma insulinCVD riskHDL cholesterolInsulin levelsPlasma leptinAntigen levelsSoluble TNF receptor levelsCardiovascular disease risk factorsTissue plasminogen activator antigen levelsT-PA antigen levelsMetabolic cardiovascular syndromeHealth Professionals FollowIndependent risk factorDisease risk factorsEffect of obesitySoluble TNF receptorsTNF receptor levelsCardiovascular disease morbidityBody mass indexLevels of insulinProfessionals FollowLeptin levelsMass indexPlasma leptin concentrations and four-year weight gain among US men
Chu N, Spiegelman D, Yu J, Rifai N, Hotamisligil G, Rimm E. Plasma leptin concentrations and four-year weight gain among US men. International Journal Of Obesity 2001, 25: 346-353. PMID: 11319631, DOI: 10.1038/sj.ijo.0801549.Peer-Reviewed Original ResearchConceptsPlasma leptin concentrationsBaseline body mass indexPlasma leptin levelsLeptin levelsSubsequent weight gainLeptin concentrationsWeight gainInsulin levelsLeptin resistanceUS menSoluble tumor necrosis factor receptor levelsTumor necrosis factor receptor levelsBaseline plasma leptin levelsElevated plasma leptin concentrationsFour-year prospective studyDetailed lifestyle questionnaireHigher baseline leptinHealth Professionals FollowBody mass indexTotal energy intakeBody fat massPlasma insulin levelsDevelopment of obesityFollow-up questionnaireBaseline leptinDietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men
Chu N, Stampfer M, Spiegelman D, Rifai N, Hotamisligil G, Rimm E. Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men. International Journal Of Obesity 2001, 25: 106-114. PMID: 11244465, DOI: 10.1038/sj.ijo.0801468.Peer-Reviewed Original ResearchConceptsBody mass indexPlasma leptin concentrationsLow plasma leptin concentrationsBody fat massLeptin concentrationsPhysical activityNormal weightOverweight menFat intakeLifestyle factorsFat massBlood samplesConfounding variablesWeight gainMonounsaturated fat intakeY weight gainRecent prospective studiesVenous blood samplesCurrent smokingObese menCholesterol intakeObese subjectsMass indexPlasma leptinProspective studyAssociation between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk 1 , 2 , 3
Fung T, Rimm E, Spiegelman D, Rifai N, Tofler G, Willett W, Hu F. Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 73: 61-67. PMID: 11124751, DOI: 10.1093/ajcn/73.1.61.Peer-Reviewed Original ResearchConceptsMajor dietary patternsFood frequency questionnaireBiomarkers of obesityDietary patternsHomocysteine concentrationsHigh intakePattern scoresHigh-fat dairy productsHealth Professionals FollowOverall dietary patternsCardiovascular disease riskBody mass indexPlasma folate concentrationsPrudent patternProfessionals FollowCVD riskDevelopment of diseaseSmoking statusAlcohol intakeMass indexPotential confoundersObesity riskPlasma biomarkersPlasma folateRisk factors
2000
Leisure-Time Physical Activity, Television Watching, and Plasma Biomarkers of Obesity and Cardiovascular Disease Risk
Fung TT, Hu FB, Yu J, Chu NF, Spiegelman D, Tofler GH, Willett WC, Rimm EB. Leisure-Time Physical Activity, Television Watching, and Plasma Biomarkers of Obesity and Cardiovascular Disease Risk. American Journal Of Epidemiology 2000, 152: 1171-1178. PMID: 11130623, DOI: 10.1093/aje/152.12.1171.Peer-Reviewed Original ResearchConceptsLeisure-time physical activityDensity lipoprotein cholesterolPhysical activityCVD riskLipoprotein cholesterolHDL cholesterolCardiovascular diseaseTelevision watchingLong-term leisure-time physical activityHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolLong-term physical activityMale health professionalsBiomarkers of obesityCardiovascular disease riskBlood lipidsThrombogenic factorsLeptin levelsInsulin sensitivityC-peptideApolipoprotein A1Vigorous activityLinear regression analysisBiochemical markersHealth professionalsGlycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men
Chu N, Spiegelman D, Rifai N, Hotamisligil G, Rimm E. Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men. International Journal Of Obesity 2000, 24: 1085-1092. PMID: 11033975, DOI: 10.1038/sj.ijo.0801361.Peer-Reviewed Original ResearchConceptsPlasma leptinSTNF-R1C-peptideOverweight menGlycemic statusLeptin concentrationsGlucose homeostasisSoluble tumor necrosis factor receptor levelsSoluble tumour necrosis factor receptor concentrationsTumor necrosis factor receptor levelsDetailed lifestyle questionnaireSTNF-R2 concentrationsHealth Professionals FollowBody mass indexPlasma leptin levelsObesity-related disordersAdipose-derived cytokineCross-sectional studyConsiderable inter-individual variationProfessionals FollowDiabetes mellitusLeptin levelsMass indexNormal weightHighest quintileProportion of colon cancer risk that might be preventable in a cohort of middle-aged US men
Platz E, Willett W, Colditz G, Rimm E, Spiegelman D, Giovannucci E. Proportion of colon cancer risk that might be preventable in a cohort of middle-aged US men. Cancer Causes & Control 2000, 11: 579-588. PMID: 10977102, DOI: 10.1023/a:1008999232442.Peer-Reviewed Original ResearchConceptsColon cancer riskMiddle-aged US menRisk factorsCancer riskRisk scoreUS menPopulation attributable risk percentColon cancer risk factorsHealth Professionals FollowModifiable risk factorsAttributable risk percentCancer risk factorsColon cancer incidenceLow-risk scoresRed meat consumptionColon cancer casesLogistic regression modelsProfessionals FollowCigarette smokingColorectal neoplasiaColorectal cancerPhysical inactivityCancer incidenceCancer casesFamily history
1996
Birth weight and adult hypertension, diabetes mellitus, and obesity in US men.
Curhan G, Willett W, Rimm E, Spiegelman D, Ascherio A, Stampfer M. Birth weight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation 1996, 94: 3246-50. PMID: 8989136, DOI: 10.1161/01.cir.94.12.3246.Peer-Reviewed Original ResearchConceptsAge-adjusted odds ratioAdult body mass indexLow birth weightBody mass indexDiabetes mellitusBirth weightAdult hypertensionMass indexOdds ratioChronic diseasesUS menChronic adult diseasesBirth weight categoriesDependent diabetes mellitusPrevalence of obesityRisk of hypertensionRisk of obesityHigh birth weightEarly life exposureCumulative incidenceLowest quintileMedical historyRisk factorsFamily historyLife exposureBirth weight and adult hypertension and obesity in women.
Curhan G, Chertow G, Willett W, Spiegelman D, Colditz G, Manson J, Speizer F, Stampfer M. Birth weight and adult hypertension and obesity in women. Circulation 1996, 94: 1310-5. PMID: 8822985, DOI: 10.1161/01.cir.94.6.1310.Peer-Reviewed Original ResearchConceptsAge-adjusted odds ratioHealth Study IIBody mass indexBirth weightYears of ageOdds ratioNHS IMass indexNurses' Health Study INurses' Health Study IIAdult body mass indexHealth Study INHS II cohortDevelopment of hypertensionLow birth weightPhysician-diagnosed hypertensionRisk of hypertensionHigh birth weightEarly life exposureAdult hypertensionNHS IIBlood pressureLowest quintileRisk factorsLife exposure
1992
Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose?
Spiegelman D, Israel R, Bouchard C, Willett W. Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose? American Journal Of Clinical Nutrition 1992, 55: 1033-1044. PMID: 1595574, DOI: 10.1093/ajcn/55.6.1033.Peer-Reviewed Original ResearchConceptsBody mass indexBlood pressurePercent body fatAbsolute fat massFat massSerum glucoseBody fatBlood glucoseDiastolic blood pressureBody fat distributionCigarette smoking statusCurrent cigarette smoking statusRegional fat distributionMultiple skinfold thicknessesRelative fat massMass indexFat distributionOverall body massSkinfold thicknessBody compositionStudy centersGold standardHip girthStrongest predictorUnderwater weighing