2004
Plasma Lipid and Lipoprotein Levels during the Follicular and Luteal Phases of the Menstrual Cycle
Barnett JB, Woods MN, Lamon-Fava S, Schaefer EJ, McNamara JR, Spiegelman D, Hertzmark E, Goldin B, Longcope C, Gorbach SL. Plasma Lipid and Lipoprotein Levels during the Follicular and Luteal Phases of the Menstrual Cycle. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 776-782. PMID: 14764796, DOI: 10.1210/jc.2003-030506.Peer-Reviewed Original ResearchConceptsMenstrual cycle phaseLuteal phasePremenopausal womenFollicular phaseMenstrual cycleTotal cholesterol/high-density lipoprotein cholesterolLow-density lipoprotein cholesterol levelsHigh-density lipoprotein cholesterolCoronary heart disease riskTotal cholesterol/HDLPremenopausal Caucasian womenLipoprotein cholesterol levelsHeart disease riskBody mass indexCholesterol/HDLLevels of LDLSex hormone levelsLevels of estradiolLipoprotein cholesterolLipoprotein levelsMass indexEstrogen levelsLipoprotein profilePlasma lipidsCholesterol levels
1999
Association of age and reproductive factors with benign breast tissue composition.
Gertig DM, Stillman IE, Byrne C, Spiegelman D, Schnitt SJ, Connolly JL, Colditz GA, Hunter DJ. Association of age and reproductive factors with benign breast tissue composition. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 873-9. PMID: 10548315.Peer-Reviewed Original ResearchConceptsStromal proportionProliferative breast diseaseBreast diseaseRisk factorsBreast tissue compositionEpithelial proportionHealth StudyReproductive breast cancer risk factorsBenign breast biopsy slidesBreast cancer risk factorsObvious mass lesionStromal breast tissueNurses' Health StudyReproductive risk factorsCancer risk factorsBenign breast biopsyBreast cancer riskCase-control studyAssociation of agePostmenopausal parous womenFibrous stromal tissueNonproliferative breast diseasePostmenopausal womenPremenopausal womenParous womenRe: Meta-analysis: Dietary Fat Intake, Serum Estrogen Levels, and the Risk of Breast Cancer
Holmes M, Schisterman E, Spiegelman D, Hunter D, Willett W. Re: Meta-analysis: Dietary Fat Intake, Serum Estrogen Levels, and the Risk of Breast Cancer. Journal Of The National Cancer Institute 1999, 91: 1511-1512. PMID: 10469759, DOI: 10.1093/jnci/91.17.1511.Peer-Reviewed Original ResearchThe relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer.
Haiman CA, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Speizer FE, Kelsey KT, Hunter DJ. The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer. Cancer Research 1999, 59: 1015-20. PMID: 10070957.Peer-Reviewed Original ResearchConceptsHealth Study cohortBreast cancer riskBreast cancerHormone levelsA2 alleleCancer riskNurses' Health Study cohortStrong independent risk factorA2/A2 genotypeCYP17 A2 alleleElevated levelsAdvanced breast cancerIncident breast cancerIndependent risk factorPolycystic ovarian syndromeCertain steroid hormonesA1/A1 genotypeCase-control studyPlasma hormone levelsSteroid hormone levelsLater agePremenopausal womenCYP17 genotypeHormone replacementOvarian syndrome
1998
Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women
Hankinson S, Willett W, Manson J, Colditz G, Hunter D, Spiegelman D, Barbieri R, Speizer F. Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women. Journal Of The National Cancer Institute 1998, 90: 1292-1299. PMID: 9731736, DOI: 10.1093/jnci/90.17.1292.Peer-Reviewed Original ResearchConceptsSex steroid hormone levelsHormone replacement therapyBreast cancer riskPostmenopausal womenBreast cancerSteroid hormone levelsBlood collectionEstrogen levelsReplacement therapyHormone levelsCancer riskHealth StudyPrevious hormone replacement therapyPlasma sex steroid hormone levelsPostmenopausal estrogen levelsNurses' Health StudyPlasma estrogen levelsLevels of estradiolCase-control studyPlasma androgen levelsBioavailable estradiolMenopausal statusSignificant positive associationControl subjectsLowest quartile
1995
Reproducibility of plasma hormone levels in postmenopausal women over a 2-3-year period.
Hankinson SE, Manson JE, Spiegelman D, Willett WC, Longcope C, Speizer FE. Reproducibility of plasma hormone levels in postmenopausal women over a 2-3-year period. Cancer Epidemiology Biomarkers & Prevention 1995, 4: 649-54. PMID: 8547832.Peer-Reviewed Original ResearchConceptsSex hormone-binding globulinIntraclass correlation coefficientPlasma hormone levelsPostmenopausal womenBioavailable estradiolPlasma levelsFree estradiolHormone levelsHealthy postmenopausal womenHormone-binding globulinLow intraclass correlation coefficientsPostmenopausal hormonesPlasma estrogenPlasma hormonesEstrone sulfateAge 51Blood samplesEstradiolWomenHormoneAndrostenedioneProlactinAgeSample collectionMenopauseChanges in plasma lipoprotein concentrations and composition in response to a low-fat, high-fiber diet are associated with changes in serum estrogen concentrations in premenopausal women
Schaefer E, Lamon-Fava S, Spiegelman D, Dwyer J, Lichtenstein A, McNamara J, Goldin B, Woods M, Morrill-LaBrode A, Hertzmark E, Longcope C, Gorbach S. Changes in plasma lipoprotein concentrations and composition in response to a low-fat, high-fiber diet are associated with changes in serum estrogen concentrations in premenopausal women. Metabolism 1995, 44: 749-756. PMID: 7783659, DOI: 10.1016/0026-0495(95)90188-4.Peer-Reviewed Original ResearchConceptsHigh-fiber dietLuteal phasePremenopausal womenTotal cholesterolPlasma lipidsBaseline dietFollicular phaseHigh-density lipoprotein cholesterol concentrationsSerum sex hormone concentrationsLow-density lipoprotein cholesterolNormal premenopausal womenLipoprotein cholesterol concentrationsSex hormone concentrationsSerum estrogen concentrationsPlasma lipoprotein concentrationsSerum estrone sulphate concentrationsEstrone sulfate concentrationsLow-density lipoproteinLipoprotein cholesterolLipoprotein levelsSerum hormonesLipoprotein concentrationsMenstrual cyclePlasma triglyceridesTG concentrations
1994
The effect of dietary fat and fiber on serum estrogen concentrations in premenopausal women under controlled dietary conditions
Goldin B, Woods M, Spiegelman D, Longcope C, Morrill‐LaBrode A, Dwyer J, Gualtieri L, Hertzmark E, Gorbach S. The effect of dietary fat and fiber on serum estrogen concentrations in premenopausal women under controlled dietary conditions. Cancer 1994, 74: 1125-1131. PMID: 8039147, DOI: 10.1002/1097-0142(19940801)74:3+<1125::aid-cncr2820741521>3.0.co;2-5.Peer-Reviewed Original ResearchConceptsPremenopausal womenSerum concentrationsSex hormonesDietary fatEstrone sulfateSerum sex hormonesSerum estrogen concentrationsSignificant decreaseInitial control periodDietary fiberMetabolic kitchenFollicular phaseMenstrual cycleFree estradiolAmount of fatEstrogen concentrationsHigh fiberDietary conditionsControl periodEstradiolIndependent effectsWomenAndrostenedioneFatHormone