2022
Iron supplementation and paediatric HIV disease progression: a cohort study among children receiving routine HIV care in Dar es Salaam, Tanzania
Andersen CT, Duggan CP, Manji K, Seage GR, Spiegelman D, Perumal N, Ulenga N, Fawzi WW. Iron supplementation and paediatric HIV disease progression: a cohort study among children receiving routine HIV care in Dar es Salaam, Tanzania. International Journal Of Epidemiology 2022, 51: 1533-1543. PMID: 35167662, PMCID: PMC9557856, DOI: 10.1093/ije/dyac017.Peer-Reviewed Original ResearchMeSH KeywordsAnemiaChildCohort StudiesDietary SupplementsDisease ProgressionHIV InfectionsHumansIronProspective StudiesTanzaniaConceptsDisease stage progressionIron supplementationStage progressionCohort studyDisease progressionRoutine HIV careHIV disease progressionProspective cohort studyManagement of anemiaRisk of anemiaHigher hazard rateProportional hazards modelIron supplement useDar es SalaamHaematological outcomesAntiretroviral therapyHIV careClinic visitsSupportive careAntiretroviral treatmentClinical outcomesClinical visitsAnemia statusSupplement useVital status
2020
Universal test and treat in relation to HIV disease progression: results from a stepped‐wedge trial in Eswatini
Boeke C, Khan S, Walsh F, Hettema A, Lejeune C, Spiegelman D, Okello V, Harwell J, Mazibuko S, Bärnighausen T. Universal test and treat in relation to HIV disease progression: results from a stepped‐wedge trial in Eswatini. HIV Medicine 2020, 22: 54-59. PMID: 32876360, DOI: 10.1111/hiv.12941.Peer-Reviewed Original ResearchConceptsBody mass indexStepped-wedge trialDisease progressionCD4 countSevere diseaseMultivariate Cox proportional hazards modelWorld Health Organization stageCox proportional hazards modelHIV disease progressionMorbidity/mortalityCells/Proportional hazards modelLower ratesIncident tuberculosisCD4 declineMass indexUniversal testHealth facilitiesBaseline valuesHazards modelHealth outcomesCrowded hospitalsWeight lossProgressionHIV
2006
HIV-1 infection and fertility in Dar es Salaam, Tanzania.
Sedgh G, Larsen U, Spiegelman D, Msamanga G, Fawzi WW. HIV-1 infection and fertility in Dar es Salaam, Tanzania. African Journal Of Reproductive Health 2006, 10: 41-52. PMID: 17518130, DOI: 10.2307/30032470.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCohort StudiesDisease ProgressionFemaleFertilityHIV InfectionsHIV-1HumansParturitionPregnancyTanzaniaConceptsHIV-1 infectionUninfected womenHIV infectionPregnancy lossMultivariate analysisHIV-1 infected womenPregnancy rate ratioRetrospective cohort studyPredictors of pregnancyHIV-positive womenNumber of pregnanciesRate of pregnancyDar es SalaamHigher pregnancy rateAdvanced diseaseCohort studyHIV seropositivityInfected womenBorderline significancePregnancy rateAdvanced stageInfectionPregnancyWomenRate ratio
2005
HIV-1 Disease Progression and Fertility in Dar es Salaam, Tanzania
Sedgh G, Larsen U, Spiegelman D, Msamanga G, Fawzi WW. HIV-1 Disease Progression and Fertility in Dar es Salaam, Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 39: 439-445. PMID: 16010167, DOI: 10.1097/01.qai.0000148529.58963.83.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCohort StudiesDisease ProgressionFemaleFertilityHIV InfectionsHumansParturitionPregnancyProspective StudiesTanzaniaConceptsHIV-1 disease progressionPregnancy rate ratioPregnancy incidenceDisease progressionRate ratioStage IHIV-1-infected womenHIV-1-positive womenCox proportional hazards modelClinical stage IIHIV-1 diseaseProspective cohort studyLive birth rateProportional hazards modelDar es SalaamLive birth incidenceCohort studyMenstrual dysfunctionIndependent predictorsRecent pregnancyHIV statusClinical progressionPregnancy rateOlder womenHazards model
2004
A Randomized Trial of Multivitamin Supplements and HIV Disease Progression and Mortality
Fawzi WW, Msamanga GI, Spiegelman D, Wei R, Kapiga S, Villamor E, Mwakagile D, Mugusi F, Hertzmark E, Essex M, Hunter DJ. A Randomized Trial of Multivitamin Supplements and HIV Disease Progression and Mortality. New England Journal Of Medicine 2004, 351: 23-32. PMID: 15229304, DOI: 10.1056/nejmoa040541.Peer-Reviewed Original ResearchConceptsVitamin AHIV diseaseMultivitamin supplementsHuman immunodeficiency virus (HIV) diseasePlacebo-controlled trialHIV disease progressionStage 4 diseaseLow viral loadHigher CD4Antiretroviral therapyPrimary outcomeImmunodeficiency syndromeRandomized trialsViral loadPregnant womenDisease progressionRelative riskObservational studyDaily supplementCell countEnd pointMicronutrient statusMultivitaminsDiseaseProgressionBreastfeeding and maternal HIV-1 disease progression and mortality
Sedgh G, Spiegelman D, Larsen U, Msamanga G, Fawzi WW. Breastfeeding and maternal HIV-1 disease progression and mortality. AIDS 2004, 18: 1043-1049. PMID: 15096808, DOI: 10.1097/00002030-200404300-00013.Peer-Reviewed Original ResearchConceptsHIV-1 disease progressionCD4 cell countDisease progressionCell countHigher CD4 cell countsLow CD4 cell countsCox proportional hazards modelHealth of HIVCohort study designExcessive weight lossProportional hazards modelPartial breastfeedingRelative riskHazards modelInsufficient evidenceBreastfeedingMultivariate analysisStudy designWeight lossWomenProgressionDar es SalaamHIVDeathAssociation
2001
Determinants of low birth weight among HIV-infected pregnant women in Tanzania 1 , 2 , 3
Dreyfuss M, Msamanga G, Spiegelman D, Hunter D, Urassa E, Hertzmark E, Fawzi W. Determinants of low birth weight among HIV-infected pregnant women in Tanzania 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 74: 814-826. PMID: 11722965, DOI: 10.1093/ajcn/74.6.814.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBirth WeightCohort StudiesDisease ProgressionFemaleHIV InfectionsHumansIncidenceInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeInfectious Disease Transmission, VerticalLymphocyte CountMalariaMaternal WelfareMiddle AgedOdds RatioParasitic DiseasesPregnancyPregnancy Complications, InfectiousPregnancy OutcomeRandomized Controlled Trials as TopicRisk FactorsTanzaniaConceptsLow birth weightInfant HIV infectionBirth weightHIV infectionMaternal weightRisk factorsIncidence of LBWLow serum vitamin E concentrationsPredictors of LBWCell countAdvanced stage HIV diseaseLower CD8 cell countsMultivariate-adjusted linear regression modelsSerum vitamin E concentrationsInfant risk factorsCD4 cell countCD8 cell countsGestational age statusHIV disease progressionIntestinal parasitic infectionsMean birth weightPlasmodium falciparum malariaHIV-positive womenMidupper arm circumferencePrenatal care clinicsDo HIV Type 1 RNA Levels Provide Additional Prognostic Value to CD4+ T Lymphocyte Counts in Patients with Advanced HIV Type 1 Infection?
Arduino J, Fischl M, Stanley K, Collier A, Spiegelman D. Do HIV Type 1 RNA Levels Provide Additional Prognostic Value to CD4+ T Lymphocyte Counts in Patients with Advanced HIV Type 1 Infection? AIDS Research And Human Retroviruses 2001, 17: 1099-1105. PMID: 11522179, DOI: 10.1089/088922201316912709.Peer-Reviewed Original ResearchConceptsHIV-1 RNA levelsHIV-1 disease progressionBaseline HIV-1 RNA levelsT-lymphocyte countsT lymphocytesDisease progressionLymphocyte countRNA levelsCells/Prognostic informationHigh baseline HIV-1 RNA levelsHIV type 1 RNA levelsPlasma HIV-1 RNA levelsSubsequent HIV-1 disease progressionAdvanced HIV-1 diseaseHIV Type 1 InfectionConditional logistic regression analysisDisease progression independentHIV-1 diseaseAdditional prognostic informationAdditional prognostic valueType 1 infectionCase-control studyLogistic regression analysisClinical status
1998
Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania
Fawzi W, Msamanga G, Spiegelman D, Urassa E, McGrath N, Mwakagile D, Antelman G, Mbise R, Kapiga S, Willett W, Hunter D, Team F, Herrera G. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. The Lancet 1998, 351: 1477-1482. PMID: 9605804, DOI: 10.1016/s0140-6736(98)04197-x.Peer-Reviewed Original ResearchConceptsHIV-1-infected womenT-cell countsHIV-1 diseaseBirth outcomesVitamin APregnancy outcomesMultivitamin supplementationHIV-1-infected pregnant womenPoor micronutrient statusTrial of effectAdverse pregnancy outcomesPlacebo-controlled trialT lymphocyte subsetsAdverse birth outcomesEffects of multivitaminsSevere preterm birthsLymphocyte subsetsPreterm birthFetal deathWeeks' gestationGestational ageClinical progressionPregnant womenLow birthweightFaster progression