2005
Dietary Patterns and the Risk of Breast Cancer
Adebamowo CA, Hu FB, Cho E, Spiegelman D, Holmes MD, Willett WC. Dietary Patterns and the Risk of Breast Cancer. Annals Of Epidemiology 2005, 15: 789-795. PMID: 16257363, DOI: 10.1016/j.annepidem.2005.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreast NeoplasmsDietFemaleHumansIncidenceMiddle AgedPremenopauseRisk FactorsSmokingConceptsPrudent dietary patternDietary patternsBreast cancerNurses' Health Study IIMajor dietary patternsHealth Study IIWestern dietary patternFood frequency questionnaireInvasive breast cancerPre-menopausal womenBreast cancer riskSecular trend studiesCumulative average scoreMultivariate RRsPremenopausal womenFrequency questionnaireLowest quintileInverse associationWestern dietCancer riskOverall associationCancerFurther evaluationStudy IIRiskDietary flavonols and flavonol‐rich foods intake and the risk of breast cancer
Adebamowo CA, Cho E, Sampson L, Katan MB, Spiegelman D, Willett WC, Holmes MD. Dietary flavonols and flavonol‐rich foods intake and the risk of breast cancer. International Journal Of Cancer 2005, 114: 628-633. PMID: 15609322, DOI: 10.1002/ijc.20741.Peer-Reviewed Original ResearchConceptsMultivariate relative riskBreast cancer riskCumulative average intakeFlavonol-rich foodsIntake of beansRelative riskBreast cancerCancer riskFlavonol intakeLowest quintileInverse associationDietary flavonolsAverage intakeNurses' Health Study IIIntake of flavonolsHealth Study IIFood frequency questionnaireInvasive breast cancerSignificant inverse associationFrequency questionnaireEpidemiological studiesAnimal studiesDietary dataOverall associationFurther evaluation
2004
Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors
Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Marshall LM, Hunter DJ. Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors. American Journal Of Epidemiology 2004, 160: 784-796. PMID: 15466501, DOI: 10.1093/aje/kwh275.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAlcohol DrinkingAnthropometryBody ConstitutionBody Mass IndexDemographyEndometriosisFemaleFollow-Up StudiesHumansIncidenceInfertility, FemaleLaparoscopyLife StyleMiddle AgedMultivariate AnalysisNursesObesityPremenopauseProportional Hazards ModelsRisk FactorsSmokingStatistics, NonparametricUnited StatesWhite PeopleConceptsBody mass indexMass indexCigarette smokingLifestyle factorsNurses' Health Study II prospective cohortMultivariate Cox proportional hazards modelWaist/hip ratioCurrent body mass indexCox proportional hazards modelCurrent alcohol intakeCurrent cigarette smokingIncidence of endometriosisAge 18 yearsProportional hazards modelAfrican American womenPast infertilityLaparoscopic diagnosisProspective cohortAlcohol intakeHip ratioInfertility statusCaucasian womenIncidence rateCaffeine intakeHazards modelManganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer
Tamimi RM, Hankinson SE, Spiegelman D, Colditz GA, Hunter DJ. Manganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 989-996. PMID: 15184255, DOI: 10.1158/1055-9965.989.13.6.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study cohortBreast cancerAla alleleCancer riskCurrent smokersCigarette smokingNurses' Health Study cohortManganese superoxide dismutase polymorphismIndependent risk factorPostmenopausal hormone useCase-control studyVal/ValHormone useStudy cohortIncident casesRisk factorsPlasma antioxidantsDismutase polymorphismAlcohol consumptionVal alleleBlood collectionCancerAntioxidant levelsOxidative stressReproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study
Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-Campbell LL, Rosenberg L. Reproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study. American Journal Of Epidemiology 2004, 159: 113-123. PMID: 14718211, PMCID: PMC1847588, DOI: 10.1093/aje/kwh016.Peer-Reviewed Original ResearchConceptsUS black womenUterine leiomyomataHormonal contraceptionReproductive factorsSelf-reported uterine leiomyomataProspective cohort studyBody mass indexIncidence rate ratiosCox regression modelSelf-reported diagnosisBlack womenAfrican American womenReproductive covariatesCohort studyPremenopausal womenAlcohol intakeMass indexProspective studyInverse associationHormonal factorsLast birthLeiomyomataReproductive historyNew casesFirst birth
2003
Premenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer.
Cho E, Spiegelman D, Hunter DJ, Chen WY, Zhang SM, Colditz GA, Willett WC. Premenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 713-20. PMID: 12917201.Peer-Reviewed Original ResearchConceptsHealth Study IIBreast cancer riskBreast cancerVitamin ACancer riskNurses' Health Study IIMultivariate relative riskFood frequency questionnaireInvasive breast cancerPrevious epidemiological studiesEarly adult lifePostmenopausal womenPremenopausal womenIncident casesHighest quintileLowest quintileRelative riskHigh intakeEpidemiological studiesNutrient intakeTotal vitaminCancerStudy IIIntakeVitamin CPremenopausal Fat Intake and Risk of Breast Cancer
Cho E, Spiegelman D, Hunter DJ, Chen WY, Stampfer MJ, Colditz GA, Willett WC. Premenopausal Fat Intake and Risk of Breast Cancer. Journal Of The National Cancer Institute 2003, 95: 1079-1085. PMID: 12865454, DOI: 10.1093/jnci/95.14.1079.Peer-Reviewed Original ResearchConceptsBreast cancer riskDietary fat intakeHigh-fat dairy foodsHealth Study IIFat intakeBreast cancerCancer riskRelative riskPremenopausal womenIncident invasive breast cancerNurses' Health Study IIElevated breast cancer riskRed meatMultivariable relative risksAnimal fat intakeFood frequency questionnaireInvasive breast cancerConfidence intervalsCase-control studyDairy foodsPremenopausal yearsPostmenopausal womenProspective studyHighest quintileLowest quintile
2000
Pooled Analysis of Prospective Cohort Studies on Height, Weight, and Breast Cancer Risk
van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, Fraser G, Goldbohm RA, Graham S, Kushi L, Marshall JR, Miller AB, Rohan T, Smith-Warner SA, Speizer FE, Willett WC, Wolk A, Hunter DJ. Pooled Analysis of Prospective Cohort Studies on Height, Weight, and Breast Cancer Risk. American Journal Of Epidemiology 2000, 152: 514-527. PMID: 10997541, DOI: 10.1093/aje/152.6.514.Peer-Reviewed Original ResearchConceptsBody mass indexProspective cohort studyPostmenopausal womenRelative riskPremenopausal womenBreast cancerRisk factorsCohort studyIncident invasive breast cancer casesBreast cancer risk factorsInvasive breast cancer casesIndependent risk factorPooled relative riskPostmenopausal breast cancerCancer risk factorsBreast cancer variesBreast cancer riskBreast cancer casesMenopausal statusCancer variesMass indexAnthropometric indicesCancer casesCancer riskWeight control
1999
Reproducibility of plasma and urinary sex hormone levels in premenopausal women over a one-year period.
Michaud DS, Manson JE, Spiegelman D, Barbieri RL, Sepkovic DW, Bradlow HL, Hankinson SE. Reproducibility of plasma and urinary sex hormone levels in premenopausal women over a one-year period. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 1059-64. PMID: 10613337.Peer-Reviewed Original ResearchConceptsPremenopausal womenIntraclass correlation coefficientLuteal phaseHormone levelsBlood samplesEndogenous sex steroid hormonesUrinary sex hormone levelsUrinary sex hormonesUrinary estrogen metabolitesSex hormone levelsSex steroid hormonesSets of bloodSingle blood sampleHigh intraclass correlation coefficientsLuteal phase samplesPlasma estrogenMenstrual cycleSex hormonesPlasma estradiolBreast cancerEstrogen metabolitesEstrone sulfateUrinary 2One-year periodSteroid hormonesOral contraceptive use and risk of melanoma in premenopausal women
Feskanich D, Hunter DJ, Willett WC, Spiegelman D, Stampfer MJ, Speizer FE, Colditz GA. Oral contraceptive use and risk of melanoma in premenopausal women. British Journal Of Cancer 1999, 81: 918-923. PMID: 10555769, PMCID: PMC2374297, DOI: 10.1038/sj.bjc.6690787.Peer-Reviewed Original ResearchConceptsCurrent OC usersOral contraceptive useRisk of melanomaOC usersRisk factorsContraceptive useSun exposureHealth Study II cohortLow-dose oestrogen pillsPast OC usersBody mass indexPossible risk factorsLonger durationPremenopausal white womenLogistic regression modelsNHS IIOC usePremenopausal womenSignificant twofold increaseMass indexSuperficial spreadingNodular melanomaSkin reactionsIncidence rateSunburn historyPrevalence and Predictors of Depressive Symptoms in Older Premenopausal Women: The Harvard Study of Moods and Cycles
Harlow BL, Cohen LS, Otto MW, Spiegelman D, Cramer DW. Prevalence and Predictors of Depressive Symptoms in Older Premenopausal Women: The Harvard Study of Moods and Cycles. JAMA Psychiatry 1999, 56: 418-424. PMID: 10232296, DOI: 10.1001/archpsyc.56.5.418.Peer-Reviewed Original ResearchConceptsDepressive symptomsPremenstrual symptomsCommunity-based cohort studyOlder premenopausal womenMenstrual cycle irregularityPrevalence of depressionCommunity-based studyCES-D scoresCurrent depressive symptomsSelf-administered questionnaireCohort studyPremenopausal womenNulliparous womenUpper tertileCigarette smokingMenstrual historyOvarian functionHarvard StudyCycle irregularityMajor depressionMood disordersLower riskDepression scoresDepression historySymptoms
1998
Vitamins A, C and E and the risk of breast cancer: results from a case-control study in Greece
Bohlke K, Spiegelman D, Trichopoulou A, Katsouyanni K, Trichopoulos D. Vitamins A, C and E and the risk of breast cancer: results from a case-control study in Greece. British Journal Of Cancer 1998, 79: 23-29. PMID: 10408688, PMCID: PMC2362172, DOI: 10.1038/sj.bjc.6690006.Peer-Reviewed Original ResearchConceptsΒ-carotene intakeBreast cancer riskCase-control studyBreast cancerOdds ratioCancer riskVitamin ESemiquantitative food frequency questionnaireBreast cancer risk factorsIntake of retinolVitamin CFood frequency questionnaireCancer risk factorsPost-menopausal womenTotal energy intakeΒ-carotene effectPremenopausal womenFrequency questionnaireControl womenVegetable intakeInverse associationRisk factorsDietary compoundsDietary dataSpecific micronutrientsRisk of Uterine Leiomyomata among Premenopausal Women in Relation to Body Size and Cigarette Smoking
Marshall L, Spiegelman D, Manson J, Goldman M, Barbieri R, Stampfer M, Willett W, Hunter D. Risk of Uterine Leiomyomata among Premenopausal Women in Relation to Body Size and Cigarette Smoking. Epidemiology 1998, 9: 511-517. PMID: 9730029, DOI: 10.1097/00001648-199809000-00007.Peer-Reviewed Original ResearchConceptsBody mass indexAdult body mass indexMass indexCigarette smokingUterine leiomyomataAge 18 yearsPremenopausal womenRelative riskBody mass index categoriesMultivariate relative riskConfidence intervalsIntact uterusOvarian functionNew diagnosisLeiomyomataIndex categoriesSmokingStudy questionnaireNew casesHysterectomyAge 25Weight gainWeight changeWomenRiskA prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata
Marshall L, Spiegelman D, Goldman M, Manson J, Colditz G, Barbieri R, Stampfer M, Hunter D. A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata. Fertility And Sterility 1998, 70: 432-439. PMID: 9757871, DOI: 10.1016/s0015-0282(98)00208-8.Peer-Reviewed Original ResearchConceptsOral contraceptive useUterine leiomyomataContraceptive useReproductive factorsOral contraceptivesProspective studySelf-reported uterine leiomyomataHistory of infertilitySelf-reported diagnosisPremenopausal nursesPremenopausal womenMedical recordsRisk factorsMAIN OUTCOMEElevated riskLast birthLeiomyomataYounger ageFirst birthNotable associationAge 13HysterectomyContraceptivesRiskAgePhysical Activity and Breast Cancer Risk in a Cohort of Young Women
Rockhill B, Willett W, Hunter D, Manson J, Hankinson S, Spiegelman D, Colditz G. Physical Activity and Breast Cancer Risk in a Cohort of Young Women. Journal Of The National Cancer Institute 1998, 90: 1555-1160. PMID: 9701365, DOI: 10.1093/jnci/90.15.1155.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study IIPhysical activityRelative riskBreast cancerCancer riskNurses' Health Study IIRR of cancerBreast cancer preventionInvasive breast cancerStrenuous physical activityConfidence intervalsLate adolescenceNonoccupational physical activityYoung adult womenProspective studyNonoccupational activitiesActive womenCancer preventionReduced riskStrenuous activityAdult womenAge 18Logistic regressionYoung women
1997
Variation in the incidence of uterine leiomyoma among premenopausal women by age and race.
Marshall LM, Spiegelman D, Barbieri RL, Goldman MB, Manson JE, Colditz GA, Willett WC, Hunter DJ. Variation in the incidence of uterine leiomyoma among premenopausal women by age and race. Obstetrics And Gynecology 1997, 90: 967-73. PMID: 9397113, DOI: 10.1016/s0029-7844(97)00534-6.Peer-Reviewed Original ResearchConceptsUterine leiomyomaRelative riskPremenopausal womenRisk factorsIncidence rateFirst oral contraceptive useWhite womenBlack womenOral contraceptive useBody mass indexHistory of infertilityPremenopausal black womenSimilar relative riskPotential risk factorsSelf-reported diagnosisAge-standardized ratesCurrent alcohol consumptionRace-specific ratesMass indexPhysical examinationPelvic examinationMedical recordsHigh prevalenceContraceptive useLast birthGeographic Variation in Breast Cancer Incidence Rates in a Cohort of U.S. Women
Laden F, Hankinson S, Spiegelman D, Neas L, Colditz G, Hunter D, Manson J, Byrne C, Rosner B, Speizer F. Geographic Variation in Breast Cancer Incidence Rates in a Cohort of U.S. Women. Journal Of The National Cancer Institute 1997, 89: 1373-1378. PMID: 9308708, DOI: 10.1093/jnci/89.18.1373.Peer-Reviewed Original ResearchConceptsBreast cancer incidence ratesCancer incidence ratesHealth Study cohortRisk factorsIncidence ratePostmenopausal womenRelative riskHealth StudyNurses' Health Study cohortAge-adjusted breast cancer incidence ratesBreast cancer risk factorsNurses' Health StudyMultivariate-adjusted analysesAge-adjusted riskBreast cancer incidenceInvasive breast cancerBreast cancer mortalityCancer risk factorsPremenopausal womenStudy cohortIncident casesCancer mortalityExcess riskCancer incidenceBreast cancer
1996
Hormone Levels During Dietary Changes in Premenopausal African-American Women
Woods M, Barnett J, Spiegelman D, Trail N, Hertzmark E, Longcope C, Gorbach S. Hormone Levels During Dietary Changes in Premenopausal African-American Women. Journal Of The National Cancer Institute 1996, 88: 1369-1374. PMID: 8827014, DOI: 10.1093/jnci/88.19.1369.Peer-Reviewed Original ResearchConceptsSerum hormone levelsSex hormone-binding globulinAfrican American womenCaucasian womenHormone levelsControl dietFree E2Menstrual cycleSurvival ratePremenopausal African American womenClinical study unitSerum hormone valuesTwo-sided statistical testsEndogenous sex hormonesHormone-binding globulinTypical North American dietSame control dietSignificant lower levelsTypes of cancerNorth American dietHigh-fiber dietConcentrations of estroneSHBG levelsSerum estrogenAndrostenedione levels
1995
Changes in plasma lipoprotein concentrations and composition in response to a low-fat, high-fiber diet are associated with changes in serum estrogen concentrations in premenopausal women
Schaefer E, Lamon-Fava S, Spiegelman D, Dwyer J, Lichtenstein A, McNamara J, Goldin B, Woods M, Morrill-LaBrode A, Hertzmark E, Longcope C, Gorbach S. Changes in plasma lipoprotein concentrations and composition in response to a low-fat, high-fiber diet are associated with changes in serum estrogen concentrations in premenopausal women. Metabolism 1995, 44: 749-756. PMID: 7783659, DOI: 10.1016/0026-0495(95)90188-4.Peer-Reviewed Original ResearchConceptsHigh-fiber dietLuteal phasePremenopausal womenTotal cholesterolPlasma lipidsBaseline dietFollicular phaseHigh-density lipoprotein cholesterol concentrationsSerum sex hormone concentrationsLow-density lipoprotein cholesterolNormal premenopausal womenLipoprotein cholesterol concentrationsSex hormone concentrationsSerum estrogen concentrationsPlasma lipoprotein concentrationsSerum estrone sulphate concentrationsEstrone sulfate concentrationsLow-density lipoproteinLipoprotein cholesterolLipoprotein levelsSerum hormonesLipoprotein concentrationsMenstrual cyclePlasma triglyceridesTG concentrations