2004
Fruit and Vegetable Intake and Risk of Major Chronic Disease
Hung HC, Joshipura KJ, Jiang R, Hu FB, Hunter D, Smith-Warner SA, Colditz GA, Rosner B, Spiegelman D, Willett WC. Fruit and Vegetable Intake and Risk of Major Chronic Disease. Journal Of The National Cancer Institute 2004, 96: 1577-1584. PMID: 15523086, DOI: 10.1093/jnci/djh296.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnalysis of VarianceCardiovascular DiseasesCause of DeathChronic DiseaseConfidence IntervalsConfounding Factors, EpidemiologicDiet SurveysFeeding BehaviorFemaleFollow-Up StudiesFruitHealth PersonnelHumansIncidenceMaleMiddle AgedNeoplasmsProportional Hazards ModelsProspective StudiesResearch DesignRisk AssessmentRisk FactorsSurveys and QuestionnairesUnited StatesVegetablesConceptsMajor chronic diseasesVegetable intakeCardiovascular diseaseChronic diseasesRelative riskHealth StudyVegetable consumptionGreen leafy vegetable intakeSemiquantitative food frequency questionnaireCox proportional hazards analysisOverall cancer incidenceTotal fruitNurses' Health StudyFood frequency questionnaireProportional hazards analysisStrong inverse associationProspective cohortGreen leafy vegetablesHighest quintileInverse associationCancer incidenceFood groupsHealth professionalsOverall healthDietary informationAssociation Between Low Birth Weight and Infant Mortality in Children Born to Human Immunodeficiency Virus 1-Infected Mothers in Tanzania
Wei R, Msamanga GI, Spiegelman D, Hertzmark E, Baylin A, Manji K, Fawzi WW. Association Between Low Birth Weight and Infant Mortality in Children Born to Human Immunodeficiency Virus 1-Infected Mothers in Tanzania. The Pediatric Infectious Disease Journal 2004, 23: 530-535. PMID: 15194834, DOI: 10.1097/01.inf.0000129691.42964.eb.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCohort StudiesConfidence IntervalsDeveloping CountriesFemaleHIV InfectionsHIV-1HumansIncidenceInfant MortalityInfant, Low Birth WeightInfant, NewbornInfectious Disease Transmission, VerticalMalePregnancyPregnancy Complications, InfectiousPregnancy OutcomeProportional Hazards ModelsRisk FactorsSex DistributionSurvival AnalysisTanzaniaConceptsLow birth weightBirth weightHIV statusHIV transmissionInfant mortalityCox proportional hazards modelHuman immunodeficiency virus-1Child's HIV statusPediatric HIV infectionHuman immunodeficiency virusRisk of mortalityImmunodeficiency virus-1Proportional hazards modelWeeks of ageAntiretroviral treatmentHIV infectionImmunodeficiency virusNeonatal mortalityPositive infantsPregnant womenPostneonatal mortalityHazards modelMortalityInfantsVirus 1Dietary Carotenoids and Risk of Lung Cancer in a Pooled Analysis of Seven Cohort Studies
Männistö S, Smith-Warner SA, Spiegelman D, Albanes D, Anderson K, van den Brandt PA, Cerhan JR, Colditz G, Feskanich D, Freudenheim JL, Giovannucci E, Goldbohm RA, Graham S, Miller AB, Rohan TE, Virtamo J, Willett WC, Hunter DJ. Dietary Carotenoids and Risk of Lung Cancer in a Pooled Analysis of Seven Cohort Studies. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 40-48. PMID: 14744731, DOI: 10.1158/1055-9965.epi-038-3.Peer-Reviewed Original ResearchConceptsLung cancer riskCancer riskRelative riskCohort studyLung cancerRisk factorsIncident lung cancer casesBeta-cryptoxanthin intakeMultivariate relative riskBeta-carotene intakeStrong risk factorLung cancer casesPotential risk factorsLutein/zeaxanthinRandom-effects modelDietary questionnaireCurrent smokersMultivitamin useHistological typeIntervention trialsPooled analysisEpidemiological evidenceCancer casesCarotenoid intakeFood composition databases
2003
Joint Association of Alcohol and Folate Intake with Risk of Major Chronic Disease in Women
Jiang R, Hu FB, Giovannucci EL, Rimm EB, Stampfer MJ, Spiegelman D, Rosner BA, Willett WC. Joint Association of Alcohol and Folate Intake with Risk of Major Chronic Disease in Women. American Journal Of Epidemiology 2003, 158: 760-771. PMID: 14561666, DOI: 10.1093/aje/kwg221.Peer-Reviewed Original ResearchConceptsMajor chronic diseasesFolate intakeChronic diseasesCardiovascular diseaseLower total folate intakeJoint associationsMultivariate relative riskNonfatal cardiovascular diseaseTotal folate intakeHigh folate intakeAdequate folate intakeAge 60 yearsLow folate intakePrimary preventionNontraumatic deathsRelative riskHigh riskPrevious historyDietary dataHeavy drinkersNew casesYoung womenDiseaseHeavy drinkingIntake
2002
Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk
Zhang SM, Hernán MA, Chen H, Spiegelman D, Willett WC, Ascherio A. Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk. Neurology 2002, 59: 1161-1169. PMID: 12391343, DOI: 10.1212/01.wnl.0000028688.75881.12.Peer-Reviewed Original ResearchConceptsRisk of PDVitamin E intakeVitamin EHigh intakeVitamin supplementsE intakeRelative riskHealth StudyHigher dietary vitamin E intakeHigh vitamin E intakePooled multivariate relative risksDietary vitamin E intakeSemiquantitative food frequency questionnaireMultivariate relative riskIncident PD casesNurses' Health StudyFood frequency questionnaireDietary vitamin CDietary vitamin EVitamin C supplementsPathogenesis of PDConsumption of nutsFrequency questionnaireConstituents of foodsHighest quintileVitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States)
Fung TT, Hunter DJ, Spiegelman D, Colditz GA, Speizer FE, Willett WC. Vitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States). Cancer Causes & Control 2002, 13: 221-230. PMID: 12020103, DOI: 10.1023/a:1015036317596.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAscorbic AcidCarcinoma, Basal CellCarotenoidsCohort StudiesConfidence IntervalsDietDietary SupplementsFemaleHumansIncidenceLogistic ModelsMiddle AgedProbabilityProspective StudiesRisk AssessmentSensitivity and SpecificitySkin NeoplasmsUnited StatesVitamin AVitamin EVitaminsConceptsBasal cell carcinomaVitamin ACell carcinomaDietary intakeRelative riskSun sensitivity factorsMultivariate relative riskFood frequency questionnaireRisk of BCCSignificant inverse associationIncidence of BCCImportant protective roleFirst diagnosisDietary factorsInverse associationSun exposureLatency periodProtective roleSpecific carotenoidsLogistic regressionVitamin CBottom quintileIntakeCarcinomaRiskPhysical Activity, Body Mass Index, and Ovulatory Disorder Infertility
Rich-Edwards JW, Spiegelman D, Garland M, Hertzmark E, Hunter DJ, Colditz GA, Willett WC, Wand H, Manson JE. Physical Activity, Body Mass Index, and Ovulatory Disorder Infertility. Epidemiology 2002, 13: 184-190. PMID: 11880759, DOI: 10.1097/00001648-200203000-00013.Peer-Reviewed Original ResearchMeSH KeywordsBody Mass IndexConfidence IntervalsExerciseFemaleHumansInfertility, FemaleLife StyleLogistic ModelsOdds RatioOvulationProspective StudiesConceptsBody mass indexOvulatory disorder infertilityHealth Study IIOvulatory infertilityRelative riskMass indexVigorous activityNurses' Health Study IIVigorous-intensity exerciseLower relative riskAmerican womenAdiposity levelsIntensity exercisePhysical activitySedentary lifestyleBMI distributionInfertilityU.S. womenStudy IIWomenUnderweightRiskWeekly activitiesAssociationHoursDietary and Adipose Tissue Gamma-Tocopherol and Risk of Myocardial Infarction
El-Sohemy A, Baylin A, Spiegelman D, Ascherio A, Campos H. Dietary and Adipose Tissue Gamma-Tocopherol and Risk of Myocardial Infarction. Epidemiology 2002, 13: 216-223. PMID: 11880764, DOI: 10.1097/00001648-200203000-00018.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAntioxidantsConfidence IntervalsCosta RicaFemaleFood AnalysisGamma-TocopherolHumansMaleMyocardial InfarctionOdds RatioConceptsDietary vitamin EMyocardial infarctionGamma-tocopherolOdds ratioVitamin ENonfatal myocardial infarctionFood frequency questionnaireCoronary heart diseasePopulation-based studyFirst myocardial infarctionConfidence intervalsConditional logistic regressionAdipose tissue samplesHighest quintileSupplement usersLowest quintileHeart diseaseInverse associationDietary intakeLower riskSubstantial inverse associationMultivariate analysisLogistic regressionTissue samplesWeak association
1999
Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age.
Garland M, Hunter DJ, Colditz GA, Spiegelman DL, Manson JE, Stampfer MJ, Willett WC. Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 1017-21. PMID: 10566558.Peer-Reviewed Original ResearchConceptsBreast cancer riskMultivariate relative riskAlcohol consumptionCancer riskRelative riskBreast cancerDrinks/weekInvasive breast cancerModerate alcohol consumptionMore drinks/weekAverage lifetime alcohol consumptionLifetime alcohol consumptionWomen age 25Past alcohol consumptionYears of agePostmenopausal womenPremenopausal womenWomen 25Age 25Young womenHeavy drinkingAge 23Drinking levelsWomenFurther studies
1998
Use of Toenail Fluoride Levels as an Indicator for the Risk of Hip and Forearm Fractures in Women
Feskanich D, Owusu W, Hunter D, Willett W, Ascherio A, Spiegelman D, Morris S, Spate V, Colditz G. Use of Toenail Fluoride Levels as an Indicator for the Risk of Hip and Forearm Fractures in Women. Epidemiology 1998, 9: 412-416. PMID: 9647905, DOI: 10.1097/00001648-199807000-00011.Peer-Reviewed Original ResearchConceptsForearm fracturesFluoride intakeOdds ratioHealth StudyVitamin D intakeDistal forearm fracturesNurses' Health StudyRisk of hipPostmenopausal hormone useBody mass indexLong-term intakeYear of birthD intakeMenopausal statusHip fractureHormone useHighest quartileMass indexOsteoporotic fracturesSmoking statusPrevious hipHeart diseaseSubsequent riskCaffeine intakeEpidemiologic studies
1997
Epidemiologic determinants of endometriosis: A hospital-based case-control study
Signorello L, Harlow B, Cramer D, Spiegelman D, Hill J. Epidemiologic determinants of endometriosis: A hospital-based case-control study. Annals Of Epidemiology 1997, 7: 267-274. PMID: 9177109, DOI: 10.1016/s1047-2797(97)00017-3.Peer-Reviewed Original ResearchConceptsCase-control studyControl groupHospital-based case-control studyInfertility-associated endometriosisBody mass indexConfidence intervalsPrimary control groupRisk of endometriosisEpidemiologic determinantsMenstrual characteristicsInfertile womenMass indexControl womenFertile womenInverse associationRisk factorsWomen's HospitalEndometriosisAlcohol consumptionAlternate control groupsWomenHospitalAssociationControl selectionSmoking
1995
Body Size and Fat Distribution as Predictors of Coronary Heart Disease among Middle-aged and Older US Men
Rimm E, Stampfer M, Giovannucci E, Ascherio A, Spiegelman D, Colditz G, Willett W. Body Size and Fat Distribution as Predictors of Coronary Heart Disease among Middle-aged and Older US Men. American Journal Of Epidemiology 1995, 141: 1117-1127. PMID: 7771450, DOI: 10.1093/oxfordjournals.aje.a117385.Peer-Reviewed Original ResearchConceptsBody mass indexCoronary heart diseaseHeart diseaseFat distributionMass indexHip ratioProspective studyRisk factorsUS menAge-related hormonal changesIncident coronary heart diseaseLong-term prospective studiesCoronary risk factorsIncident coronary eventsStrong risk factorOlder US menRelative risk estimatesYears of ageCoronary eventsLean menCoronary diseaseObese menIndependent predictorsLong followRelative risk
1992
Correction of Logistic Regression Relative Risk Estimates and Confidence Intervals for Random Within-Person Measurement Error
Rosner B, Spiegelman D, Willett WC. Correction of Logistic Regression Relative Risk Estimates and Confidence Intervals for Random Within-Person Measurement Error. American Journal Of Epidemiology 1992, 136: 1400-1413. PMID: 1488967, DOI: 10.1093/oxfordjournals.aje.a116453.Peer-Reviewed Original ResearchConceptsRelative risk estimatesRisk factorsLogistic regressionRisk estimatesCoronary risk factorsCoronary heart diseaseGold standardConfidence intervalsFramingham Heart StudyExamination 4Extreme quintilesHeart diseaseOdds ratioHeart StudyExamination 2Exposure assessmentSubstudyCovariatesMenMain studyReproducibility dataRegressionFactorsQuintileIncidence
1990
CORRECTION OF LOGISTIC REGRESSION RELATIVE RISK ESTIMATES AND CONFIDENCE INTERVALS FOR MEASUREMENT ERROR: THE CASE OF MULTIPLE COVARIATES MEASURED WITH ERROR
ROSNER B, SPIEGELMAN D, WILLETT WC. CORRECTION OF LOGISTIC REGRESSION RELATIVE RISK ESTIMATES AND CONFIDENCE INTERVALS FOR MEASUREMENT ERROR: THE CASE OF MULTIPLE COVARIATES MEASURED WITH ERROR. American Journal Of Epidemiology 1990, 132: 734-745. PMID: 2403114, DOI: 10.1093/oxfordjournals.aje.a115715.Peer-Reviewed Original ResearchMeSH KeywordsBiasConfidence IntervalsHumansLogistic ModelsProspective StudiesRegression AnalysisRisk FactorsStatistics as TopicConceptsAge-adjusted relative riskRelative riskRisk factorsFat intakeMultiple logistic regression modelBreast cancer riskConfidence intervalsTrue risk factorRelative risk estimatesValidation studyLogistic regression modelsMultivariate linear regression modelRegression modelsAlcohol intakeProspective studyDietary fatBreast cancerCancer riskLogistic regressionRisk estimatesIntakeRiskSeparate validation studyContinuous variablesPositive association