2017
Evaluating Public Health Interventions: 7. Let the Subject Matter Choose the Effect Measure: Ratio, Difference, or Something Else Entirely.
Spiegelman D, Khudyakov P, Wang M, Vanderweele TJ. Evaluating Public Health Interventions: 7. Let the Subject Matter Choose the Effect Measure: Ratio, Difference, or Something Else Entirely. American Journal Of Public Health 2017, 108: 73-76. PMID: 29161073, PMCID: PMC5719681, DOI: 10.2105/ajph.2017.304105.Peer-Reviewed Original ResearchConceptsRisk factor distributionRisk ratioLife yearsEffect measuresDisability-adjusted life yearsIncremental cost-effectiveness ratioPopulation attributable riskQuality-adjusted life yearsCost-effectiveness ratioPublic health interventionsPublic health evaluationYears of lifeMeasure of effectRisk factorsRelative riskStudy populationRisk differenceHealth interventionsIntervention effectsAbsolute effect measuresHealth evaluationExternal generalizabilityRiskAbsolute measuresPopulationEvaluating Public Health Interventions: 6. Modeling Ratios or Differences? Let the Data Tell Us.
Spiegelman D, VanderWeele TJ. Evaluating Public Health Interventions: 6. Modeling Ratios or Differences? Let the Data Tell Us. American Journal Of Public Health 2017, 107: 1087-1091. PMID: 28590865, PMCID: PMC5463222, DOI: 10.2105/ajph.2017.303810.Peer-Reviewed Original Research
2009
The relationship between handedness and risk of multiple sclerosis
Gardener H, Munger K, Chitnis T, Spiegelman D, Ascherio A. The relationship between handedness and risk of multiple sclerosis. Multiple Sclerosis Journal 2009, 15: 587-592. PMID: 19389750, PMCID: PMC2771381, DOI: 10.1177/1352458509102622.Peer-Reviewed Original ResearchConceptsMultiple sclerosisHealth StudyHand preferenceOngoing prospective cohort studyUtero hormone exposureNurses' Health StudyProspective cohort studyMultiple sclerosis riskSex steroid hormonesLeft-handed womenLeft-handed individualsCohort studyAutoimmune disordersIncident casesUtero exposureUnknown etiologyPrenatal exposureSex hormonesImmune disordersStudy populationHormone exposureSclerosisFemale nursesSteroid hormonesRisk
2003
A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk.
Han J, Hankinson SE, De Vivo I, Spiegelman D, Tamimi RM, Mohrenweiser HW, Colditz GA, Hunter DJ. A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. Cancer Research 2003, 63: 8536-41. PMID: 14679022.Peer-Reviewed Original ResearchConceptsBreast cancer riskBeta-carotene levelsCancer riskInverse associationHealth StudyXRCC1 geneNurses' Health StudyMultivariate odds ratiosCase-control studyPotential protective effectPresent study populationHaplotype-tagging single nucleotide polymorphismsXRCC1 haplotypesCigarette smokingProspective studyCaucasian womenEffect modificationOdds ratioBreast cancerProtective effectStudy populationOxidative DNA damageBreast carcinogenesisGene-environment interactionsPlasma carotenoidsThe Use of B Vitamin Supplements and Peripheral Arterial Disease Risk in Men Are Inversely Related
Merchant AT, Hu FB, Spiegelman D, Willett WC, Rimm EB, Ascherio A. The Use of B Vitamin Supplements and Peripheral Arterial Disease Risk in Men Are Inversely Related. Journal Of Nutrition 2003, 133: 2863-2867. PMID: 12949378, DOI: 10.1093/jn/133.9.2863.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseasePAD riskFolate intakePrevention of PADPeripheral arterial disease riskVitamin BArterial disease riskIncident PAD casesU.S. health professionalsB vitamin intakeVitamin supplement useB-vitamin supplementsCoronary heart diseaseWeak inverse associationMultivariate adjustmentArterial diseaseVitamin intakeSupplement useHeart diseaseInverse associationCardiovascular diseaseD incrementStudy populationVitamin supplementsDietary folate
2002
Weight Loss and Survival in HIV-Positive Patients in the Era of Highly Active Antiretroviral Therapy
Tang AM, Forrester J, Spiegelman D, Knox TA, Tchetgen E, Gorbach SL. Weight Loss and Survival in HIV-Positive Patients in the Era of Highly Active Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2002, 31: 230-236. PMID: 12394802, DOI: 10.1097/01.qai.0000026514.98625.8f.Peer-Reviewed Original ResearchConceptsActive antiretroviral therapyWeight lossAntiretroviral therapyHAART useIndependent predictorsPrevious visitHighly Active Antiretroviral TherapyHealthy Living StudyCD4 cell countHIV-positive patientsHIV-positive participantsBody mass indexStrong independent predictorFurther prognostic valueProportional hazards modelBioelectrical impedance analysisFour- to sixfold increaseImportant comorbidityMass indexPrognostic valuePotential confoundersRelative riskStudy populationLiving StudyHazards model
2001
The correlates of dietary intake among HIV-positive adults 1 , 2 , 3
Kim J, Spiegelman D, Rimm E, Gorbach S. The correlates of dietary intake among HIV-positive adults 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 74: 852-861. PMID: 11722969, DOI: 10.1093/ajcn/74.6.852.Peer-Reviewed Original ResearchConceptsHigher energy intakeDietary intakeEnergy intakeHIV infectionClinical outcomesDietary adequacyAdverse clinical outcomesAbsence of nauseaInadequate dietary intakeInadequate protein intakeInadequate energy intakeInjection drug usersCross-sectional studyStudy cohortFemale sexDiet recordsReduced appetiteDietary inadequacyStudy populationProtein intakeDietary allowanceDrug usersDiverse cohortIntakeWeight loss
1994
Validation of the Gail et al. Model for Predicting Individual Breast Cancer Risk
Spiegelman D, Colditz GA, Hunter D, Hertzmark E. Validation of the Gail et al. Model for Predicting Individual Breast Cancer Risk. Journal Of The National Cancer Institute 1994, 86: 600-607. PMID: 8145275, DOI: 10.1093/jnci/86.8.600.Peer-Reviewed Original ResearchConceptsBreast cancer riskNurses' Health StudyIndividual breast cancer riskCancer riskBreast cancerHealth StudyGail et alAbsolute breast cancer riskPopulation-based studyMammography screening ratesExtensive family historyIndividual woman's riskPremenopausal womenAnnual screeningPrevention trialsScreening ratesRisk factorsCancer casesFamily historyTrial investigatorsStudy populationWoman's riskCancerPrevention effortsStudy period