2005
Temporal Relationship Between Elevation of Epstein-Barr Virus Antibody Titers and Initial Onset of Neurological Symptoms in Multiple Sclerosis
Levin LI, Munger KL, Rubertone MV, Peck CA, Lennette ET, Spiegelman D, Ascherio A. Temporal Relationship Between Elevation of Epstein-Barr Virus Antibody Titers and Initial Onset of Neurological Symptoms in Multiple Sclerosis. JAMA 2005, 293: 2496-2500. PMID: 15914750, DOI: 10.1001/jama.293.20.2496.Peer-Reviewed Original ResearchConceptsViral capsid antigenEpstein-Barr virusMultiple sclerosisAntibody titersEBNA complexRelative riskDevelopment of MSEBV viral capsid antigenEpstein-Barr virus (EBV) antibody titersRisk of MSOnset of MSOnset of symptomsVirus antibody titersSerum antibody titersCase-control studyDefense Serum RepositoryAge 25 yearsBlood sample collectionUS military personnelTemporal relationshipCase-control setsRace/ethnicityAge-dependent relationshipEBV infectionCytomegalovirus antibodies
2001
Epstein-Barr Virus Antibodies and Risk of Multiple Sclerosis: A Prospective Study
Ascherio A, Munger KL, Lennette ET, Spiegelman D, Hernán MA, Olek MJ, Hankinson SE, Hunter DJ. Epstein-Barr Virus Antibodies and Risk of Multiple Sclerosis: A Prospective Study. JAMA 2001, 286: 3083-3088. PMID: 11754673, DOI: 10.1001/jama.286.24.3083.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusViral capsid antigenCases of MSGeometric mean titersHealth Study IIMultiple sclerosisSerum antibody titersRelative riskAntibody titersDisease onsetEBNA-2Health StudyRole of EBVNurses' Health Study IIEBV viral capsid antigenEpstein-Barr virus antibodiesEtiology of MSOccurrence of MSHealthy age-matched controlsNurses' Health StudyCorresponding relative risksCase-control studyAge-matched controlsCMV antigensEBV antibodies