2022
Design and Implementation of a Culturally-Tailored Randomized Pilot Trial: Puerto Rican Optimized Mediterranean-Like Diet
Mattei J, Díaz-Alvarez C, Alfonso C, O’Neill H, Ríos-Bedoya C, Malik V, Godoy-Vitorino F, Cheng C, Spiegelman D, Willett W, Hu F, Rodríguez-Orengo J. Design and Implementation of a Culturally-Tailored Randomized Pilot Trial: Puerto Rican Optimized Mediterranean-Like Diet. Current Developments In Nutrition 2022, 7: 100022. PMID: 37181130, PMCID: PMC10100940, DOI: 10.1016/j.cdnut.2022.100022.Peer-Reviewed Original ResearchMediterranean-like dietNutritional counseling sessionsPilot trialHealthier cardiometabolic profileIndividual cardiometabolic factorsCardiometabolic risk factorsRandomized pilot trialDisease prevention programsCounseling sessionsDaily text messagesFree-living adultsCardiometabolic factorsCardiometabolic profileCardiometabolic healthSecondary outcomesPrimary outcomeRisk factorsDietary intakeIntervention groupChronic diseasesTwo-armOutcome measuresHigh riskMediterranean dietPsychosocial factorsCardiovascular Risk Factors Mediate the Long-Term Maternal Risk Associated With Hypertensive Disorders of Pregnancy
Stuart JJ, Tanz LJ, Rimm EB, Spiegelman D, Missmer SA, Mukamal KJ, Rexrode KM, Rich-Edwards JW. Cardiovascular Risk Factors Mediate the Long-Term Maternal Risk Associated With Hypertensive Disorders of Pregnancy. Journal Of The American College Of Cardiology 2022, 79: 1901-1913. PMID: 35550687, PMCID: PMC9176211, DOI: 10.1016/j.jacc.2022.03.335.Peer-Reviewed Original ResearchConceptsCVD risk factorsRates of CVDHealth Study IIRisk of CVDBody mass indexGestational hypertensionType 2 diabetesRisk factorsChronic hypertensionHypertensive disordersMass indexNurses' Health Study IIPrepregnancy body mass indexHistory of HDPCardiovascular risk factorsOverweight/obesityProportional hazards modelIncident CVDCVD preventionNormotensive pregnanciesFirst pregnancyPotential confoundersParental historyHypertensionHazards modelAnemia Etiology in Ethiopia: Assessment of Nutritional, Infectious Disease, and Other Risk Factors in a Population-Based Cross-Sectional Survey of Women, Men, and Children
Andersen CT, Tadesse AW, Bromage S, Fekadu H, Hemler EC, Passarelli S, Spiegelman D, Sudfeld CR, Worku A, Berhane Y, Fawzi WW. Anemia Etiology in Ethiopia: Assessment of Nutritional, Infectious Disease, and Other Risk Factors in a Population-Based Cross-Sectional Survey of Women, Men, and Children. Journal Of Nutrition 2022, 152: 501-512. PMID: 34647598, PMCID: PMC8990104, DOI: 10.1093/jn/nxab366.Peer-Reviewed Original ResearchConceptsRisk factorsAnemia casesPopulation-based cross-sectional studyFolic acid food fortificationC-reactive protein levelsInfectious diseasesPopulation attributable risk percentageVitamin B12Proportion of anemiaDietary iron intakeCause of anemiaHelminth infection statusAttributable risk percentageLow serum ferritinLow serum folateVenous blood samplesPopulation-weighted prevalenceCross-sectional studyPublic health interventionsPotential public health interventionsCross-sectional surveyAssessment of NutritionalIron interventionsSerum ferritinAnemia etiology
2021
A Bayesian approach for estimating the partial potential impact fraction with exposure measurement error under a main study/internal validation design
Chen X, Chang J, Spiegelman D, Li F. A Bayesian approach for estimating the partial potential impact fraction with exposure measurement error under a main study/internal validation design. Statistical Methods In Medical Research 2021, 31: 404-418. PMID: 34841964, DOI: 10.1177/09622802211060514.Peer-Reviewed Original ResearchConceptsPotential impact fractionImpact fractionExposure measurement errorHealth professionalsStudy designColorectal cancer incidenceValidation study designBurden of diseaseRisk factorsCancer incidenceHealth StudyDisease casesPublic health studiesRed meatContinuous exposureExposureProfessionalsIncidenceReclassification approachValidation designDiseaseIntakeTeen Pregnancy Risk Factors Among Young Women of Diverse Sexual Orientations
Charlton B, Roberts A, Rosario M, Katz-Wise S, Calzo J, Spiegelman D, Austin S. Teen Pregnancy Risk Factors Among Young Women of Diverse Sexual Orientations. 2021, 49-58. DOI: 10.1542/9781610025409-teen.Peer-Reviewed Original ResearchSexual minoritiesPregnancy risk factorsTeen pregnancy riskDiverse sexual orientationsSexual orientation groupsTeen pregnancyRisk factorsSexual orientation-related discriminationYoung womenTeen pregnancy prevention effortsSexual orientationGender nonconformityChildhood maltreatmentMultivariable log-binomial modelsOrientation groupsDevelopmental milestonesMinorityPotential risk factorsPregnancy prevention effortsMaltreatmentLog-binomial modelsBullyingActivity involvementPrevention effortsPregnancy risk
2020
Cardiovascular disease trends in Nepal – An analysis of global burden of disease data 2017
Bhattarai S, Aryal A, Pyakurel M, Bajracharya S, Baral P, Citrin D, Cox H, Dhimal M, Fitzpatrick A, Jha AK, Jha N, Karmacharya BM, Koju R, Maharjan R, Oli N, Pyakurel P, Sapkota BP, Shrestha R, Shrestha S, Spiegelman D, Vaidya A, Shrestha A. Cardiovascular disease trends in Nepal – An analysis of global burden of disease data 2017. IJC Heart & Vasculature 2020, 30: 100602. PMID: 32775605, PMCID: PMC7399110, DOI: 10.1016/j.ijcha.2020.100602.Peer-Reviewed Original ResearchBurden of CVDCardiovascular diseaseGlobal burdenBlood pressureTotal DALYsRisk factorsDiet lowTotal deathsHigh low-density lipoprotein cholesterolHigher systolic blood pressureLow-density lipoprotein cholesterolMajor public health problemCardiovascular disease trendsPredominant cardiovascular diseasesCardiovascular disease incidenceDensity lipoprotein cholesterolSystolic blood pressureHigh blood pressureIschemic heart diseaseBody mass indexEvaluation's Global BurdenPublic health problemOlder age groupsLipoprotein cholesterolMiddle-income countriesSocio-demographic characteristics and risk factors for HIV transmission in female bar workers in sub-Saharan Africa: a systematic literature review
Dambach P, Mahenge B, Mashasi I, Muya A, Barnhart DA, Bärnighausen TW, Spiegelman D, Harling G. Socio-demographic characteristics and risk factors for HIV transmission in female bar workers in sub-Saharan Africa: a systematic literature review. BMC Public Health 2020, 20: 697. PMID: 32414352, PMCID: PMC7227324, DOI: 10.1186/s12889-020-08838-8.Peer-Reviewed Original ResearchConceptsTransactional sexSocio-demographic characteristicsFemale bar workersRisk factorsUnskilled womenSocial marginalizationSex workBar workersSaharan AfricaEconomic needsLow wagesHIV transmissionFinancial independenceSocietal levelHIV risk awarenessSex workersQualitative dataBar workSocial stigmatizationHIV prevention interventionsStructural interventionsLess considerationVulnerable populationsWorkersPeer pressureEstimation and inference for the population attributable risk in the presence of misclassification
Wong BHW, Lee J, Spiegelman D, Wang M. Estimation and inference for the population attributable risk in the presence of misclassification. Biostatistics 2020, 22: 805-818. PMID: 32112073, PMCID: PMC8966954, DOI: 10.1093/biostatistics/kxz067.Peer-Reviewed Original ResearchConceptsPopulation attributable riskAttributable riskPartial population attributable riskHigh red meat intakeColorectal cancer incidenceRed meat intakeAlcohol intakeRisk factorsCancer incidenceMeat intakeEpidemiologic studiesPublic health researchDisease casesStudy designValidation study designInternal validation studyHealth researchTarget populationIntakeValidation studyRiskHealth evaluation methodPresence of misclassificationIncidenceDisease
2019
Substituting brown rice for white rice on diabetes risk factors in India: a randomised controlled trial
Malik V, Sudha V, Wedick N, RamyaBai M, Vijayalakshmi P, Lakshmipriya N, Gayathri R, Kokila A, Jones C, Hong B, Li R, Krishnaswamy K, Anjana R, Spiegelman D, Willett W, Hu F, Mohan V. Substituting brown rice for white rice on diabetes risk factors in India: a randomised controlled trial. British Journal Of Nutrition 2019, 121: 1389-1397. PMID: 31006420, PMCID: PMC6948352, DOI: 10.1017/s000711451900076x.Peer-Reviewed Original ResearchConceptsBrown rice groupMetabolic syndromePrimary outcomeRisk factorsHigh-sensitivity C-reactive proteinRandomised cross-over trialT2D risk factorsDiabetes risk factorsC-reactive proteinCross-over trialType 2 diabetesWhite rice groupMeals/dHs-CRPSecondary outcomesElevated BMIWashout periodInsulin resistanceBlood glucoseEpidemiological evidenceWhite riceT2D riskUrban South IndiaBMISyndrome
2018
The effect of risk factor misclassification on the partial population attributable risk
Wong BHW, Peskoe SB, Spiegelman D. The effect of risk factor misclassification on the partial population attributable risk. Statistics In Medicine 2018, 37: 1259-1275. PMID: 29333614, PMCID: PMC6003717, DOI: 10.1002/sim.7559.Peer-Reviewed Original ResearchConceptsPartial population attributable riskPopulation attributable riskRisk factorsAttributable riskRelative riskMultivariate-adjusted relative riskRed meatHealth Professionals FollowModifiable risk factorsLow folate intakeExposure of interestBackground risk factorsProfessionals FollowAlcohol intakeColorectal cancerFolate intakePublic health researchMultifactorial diseasePreventive interventionsPopulation-level impactJoint prevalenceHealth researchRiskIntakeExposure
2017
Evaluating Public Health Interventions: 7. Let the Subject Matter Choose the Effect Measure: Ratio, Difference, or Something Else Entirely.
Spiegelman D, Khudyakov P, Wang M, Vanderweele TJ. Evaluating Public Health Interventions: 7. Let the Subject Matter Choose the Effect Measure: Ratio, Difference, or Something Else Entirely. American Journal Of Public Health 2017, 108: 73-76. PMID: 29161073, PMCID: PMC5719681, DOI: 10.2105/ajph.2017.304105.Peer-Reviewed Original ResearchConceptsRisk factor distributionRisk ratioLife yearsEffect measuresDisability-adjusted life yearsIncremental cost-effectiveness ratioPopulation attributable riskQuality-adjusted life yearsCost-effectiveness ratioPublic health interventionsPublic health evaluationYears of lifeMeasure of effectRisk factorsRelative riskStudy populationRisk differenceHealth interventionsIntervention effectsAbsolute effect measuresHealth evaluationExternal generalizabilityRiskAbsolute measuresPopulationEvaluating Public Health Interventions: 6. Modeling Ratios or Differences? Let the Data Tell Us.
Spiegelman D, VanderWeele TJ. Evaluating Public Health Interventions: 6. Modeling Ratios or Differences? Let the Data Tell Us. American Journal Of Public Health 2017, 107: 1087-1091. PMID: 28590865, PMCID: PMC5463222, DOI: 10.2105/ajph.2017.303810.Peer-Reviewed Original Research
2014
Who are they? Identifying risk factors of loss to follow up among HIV+ patients on care and treatment in Dar es Salaam
Machumi L, Mtisi E, Andrew I, Sando D, Mkali H, Liu E, Hertzmark E, Spiegelman D, Fawzi W, Chalamilla G. Who are they? Identifying risk factors of loss to follow up among HIV+ patients on care and treatment in Dar es Salaam. BMC Infectious Diseases 2014, 14: p78. PMCID: PMC4221014, DOI: 10.1186/1471-2334-14-s2-p78.Peer-Reviewed Original Research
2013
Determinants of anemia in postpartum HIV-negative women in Dar es Salaam, Tanzania
Petraro P, Duggan C, Urassa W, Msamanga G, Makubi A, Spiegelman D, Fawzi WW. Determinants of anemia in postpartum HIV-negative women in Dar es Salaam, Tanzania. European Journal Of Clinical Nutrition 2013, 67: 708-717. PMID: 23612515, PMCID: PMC3775569, DOI: 10.1038/ejcn.2013.71.Peer-Reviewed Original ResearchMeSH KeywordsAnemia, Iron-DeficiencyCD4 Lymphocyte CountDietDietary SupplementsErythrocyte IndicesFemaleFolic AcidHemoglobinsHIV InfectionsHumansIron, DietaryMaternal Nutritional Physiological PhenomenaMultivariate AnalysisPostpartum PeriodPregnancyProportional Hazards ModelsProspective StudiesRisk FactorsSocioeconomic FactorsTanzaniaConceptsIron/folate supplementationIron deficiency anemiaDeterminants of anemiaDeficiency anemiaFolate supplementationDelivery complicationsPregnant womenRisk factorsMultivariate Cox proportional hazards modelNon-anemic pregnant womenCox proportional hazards modelCD4 cell countHIV-negative womenModifiable risk factorsProspective cohort studyMaternal nutritional statusWeeks of gestationManagement of infectionsProportional hazards modelDar es SalaamSub-Saharan African womenBaseline anemiaIncident anemiaAnemic womenPostpartum anemia
2012
Cohort studies around the world: Methodologies, research questions and integration to address the emerging global epidemic of chronic diseases
Nair H, Shu XO, Volmink J, Romieu I, Spiegelman D. Cohort studies around the world: Methodologies, research questions and integration to address the emerging global epidemic of chronic diseases. Public Health 2012, 126: 202-205. PMID: 22325615, DOI: 10.1016/j.puhe.2011.12.013.Peer-Reviewed Original ResearchConceptsChronic diseasesCohort studyChronic non-communicable diseasesNon-communicable chronic diseasesDual disease burdenCommunicable infectious diseasesNon-communicable diseasesMultiple cohort studiesResource-constrained settingsDisease burdenRisk factorsLifestyle changesGlobal epidemicInfectious diseasesDiseaseDisease distributionEpidemicBurdenPopulationSettingDramatic increase
2011
Perinatal and Neonatal Risk Factors for Autism: A Comprehensive Meta-Analysis
Gardener H, Spiegelman D, Buka S. Perinatal and Neonatal Risk Factors for Autism: A Comprehensive Meta-Analysis. Obstetrical & Gynecological Survey 2011, 66: 749-751. DOI: 10.1097/ogx.0b013e31824024d4.Peer-Reviewed Original ResearchNeonatal factorsRisk of autismNeonatal complicationsBirth weightRisk factorsAbnormal fetal presentationEffect estimatesUmbilical cord complicationsNeonatal risk factorsLow birth weightHigh birth weightSearch of PubMedSummary effect estimatesRandom-effects modelExtensive epidemiologic researchComprehensive Meta-AnalysisRisk factor effectsApgar scoreFirst systematic reviewFetal distressMeconium aspirationBirth injuryMaternal hemorrhageVaginal deliveryGestational ageAN APPLICATION OF A RISK SET CALIBRATION METHOD TO A STUDY OF AIR POLLUTION EFFECTS ON ALL CAUSE MORTALITY IN THE NURSES’ HEALTH STUDY
Liao X, Spiegelman D, Hart J, Hong B, Puett R, Suh H, Laden F. AN APPLICATION OF A RISK SET CALIBRATION METHOD TO A STUDY OF AIR POLLUTION EFFECTS ON ALL CAUSE MORTALITY IN THE NURSES’ HEALTH STUDY. ISEE Conference Abstracts 2011, 2011 DOI: 10.1289/isee.2011.00990.Peer-Reviewed Original ResearchCause mortalityRelative riskHealth StudyChronic exposureChronic PM2.5 exposureNurses' Health StudyIndividual exposure levelsAverage of PM2.5Risk factorsExposure measurement errorState of residenceEstimates of riskParticipants' residencesPM2.5 exposureHealth outcomesMortalityMonthly exposureExposure levelsPersonal exposureExposure monitoringRiskCalendar yearAir pollution effectsExposureMidwestern metropolitan areaSocio-economic status, urbanization, and cardiometabolic risk factors among middle-aged adults in Tanzania.
Njelekela MA, Liu E, Mpembeni R, Muhihi A, Mligiliche N, Spiegelman D, Finkelstein JL, Fawzi WW, Willett WC, Mtabaji J. Socio-economic status, urbanization, and cardiometabolic risk factors among middle-aged adults in Tanzania. East African Journal Of Public Health 2011, 8: 216-23. PMID: 23120960.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood GlucoseBlood PressureBody Mass IndexCardiovascular DiseasesCross-Sectional StudiesDietExerciseFemaleHealth BehaviorHumansLife StyleLipidsLogistic ModelsMaleMetabolic SyndromeMiddle AgedObesityResidence CharacteristicsRisk FactorsSocioeconomic FactorsSurveys and QuestionnairesTanzaniaUrban HealthUrbanizationWaist CircumferenceConceptsCardiometabolic risk factorsPoorer lipid profileHigher socioeconomic statusRisk factorsLipid profileSocioeconomic statusUrban residenceCardio-metabolic risk factorsWorld Health Organization criteriaHigher total cholesterolHigh waist circumferenceRisk of obesityHealth screening strategiesMiddle-aged adultsMetabolic syndromeTotal cholesterolWaist circumferenceLDL cholesterolHigher BMIPrimary preventionLower triglyceridesOrganization criteriaDietary factorsCardiovascular diseaseGlucose levelsAnemia in TB patients predicts recurrence and mortality
Isanaka S, Mugusi F, Urassa W, Bosch R, Villamor E, Spiegelman D, Duggan C, Fawzi W. Anemia in TB patients predicts recurrence and mortality. The FASEB Journal 2011, 25: 779.14-779.14. DOI: 10.1096/fasebj.25.1_supplement.779.14.Peer-Reviewed Original ResearchTreatment failureIron deficiencyHypochromic microcytosisHIV-TB patientsCause of anemiaPoor clinical outcomeRisk of recurrenceMeasures of anemiaTuberculosis recurrenceHIV patientsTB patientsClinical outcomesSevere anemiaRisk factorsAnemiaOverall healthPatientsRecurrenceMortalityRiskMicrocytosisSignificant improvementAssociationDeficiencyFocused management
2007
Point and interval estimates of partial population attributable risks in cohort studies: examples and software
Spiegelman D, Hertzmark E, Wand HC. Point and interval estimates of partial population attributable risks in cohort studies: examples and software. Cancer Causes & Control 2007, 18: 571-579. PMID: 17387622, DOI: 10.1007/s10552-006-0090-y.Peer-Reviewed Original ResearchConceptsCohort studyRisk factorsPartial population attributable riskNon-modifiable risk factorsSpecific exposuresPopulation attributable risk percentAttributable risk percentPopulation attributable riskBladder cancer incidenceGroups of exposureTarget populationProportion of diseaseAttributable riskDisease burdenModifiable determinantsCancer incidencePublic health researchDiseaseHealth researchExposurePopulationIncidenceProportion