2021
Religion, spirituality and diurnal rhythms of salivary cortisol and dehydroepiandrosterone in postmenopausal women
Isehunwa OO, Warner ET, Spiegelman D, Huang T, Tworoger SS, Kent BV, Shields AE. Religion, spirituality and diurnal rhythms of salivary cortisol and dehydroepiandrosterone in postmenopausal women. Comprehensive Psychoneuroendocrinology 2021, 7: 100064. PMID: 34308392, PMCID: PMC8297624, DOI: 10.1016/j.cpnec.2021.100064.Peer-Reviewed Original ResearchCortisol/DHEA ratioHPA axis biomarkersDHEA ratioHigher cortisol/DHEA ratioNurses' Health Study II participantsDiurnal rhythmCross-sectional associationsLate sleep schedulesHigher cortisol levelsPostmenopausal womenAdrenal axisCortisol levelsHealth outcomesPotential covariatesDehydroepiandrosteroneCortisolSalivary cortisolSaliva samplesObserved associationsS measuresWomenExperience scoresAssociationBiomarkersSleep schedule
2005
Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status
Hines LM, Hunter DJ, Stampfer MJ, Spiegelman D, Chu NF, Rifai N, Hankinson SE, Rimm EB. Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status. Atherosclerosis 2005, 182: 293-300. PMID: 16051248, DOI: 10.1016/j.atherosclerosis.2005.02.005.Peer-Reviewed Original ResearchConceptsHigh-density lipoprotein levelsPostmenopausal hormonesPostmenopausal womenModerate alcohol consumptionHDL levelsOlder-aged menPremenopausal womenAlcohol consumptionADH1C genotypeLipoprotein levelsAged menCoronary heart diseaseMenopausal statusExogenous estrogenMyocardial infarctionHeart diseaseModerate drinkersOlder menFunctional polymorphismsWomenType 1CMenVaried exposureAssociationHigh levels
2003
Premenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer.
Cho E, Spiegelman D, Hunter DJ, Chen WY, Zhang SM, Colditz GA, Willett WC. Premenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 713-20. PMID: 12917201.Peer-Reviewed Original ResearchConceptsHealth Study IIBreast cancer riskBreast cancerVitamin ACancer riskNurses' Health Study IIMultivariate relative riskFood frequency questionnaireInvasive breast cancerPrevious epidemiological studiesEarly adult lifePostmenopausal womenPremenopausal womenIncident casesHighest quintileLowest quintileRelative riskHigh intakeEpidemiological studiesNutrient intakeTotal vitaminCancerStudy IIIntakeVitamin CPremenopausal Fat Intake and Risk of Breast Cancer
Cho E, Spiegelman D, Hunter DJ, Chen WY, Stampfer MJ, Colditz GA, Willett WC. Premenopausal Fat Intake and Risk of Breast Cancer. Journal Of The National Cancer Institute 2003, 95: 1079-1085. PMID: 12865454, DOI: 10.1093/jnci/95.14.1079.Peer-Reviewed Original ResearchConceptsBreast cancer riskDietary fat intakeHigh-fat dairy foodsHealth Study IIFat intakeBreast cancerCancer riskRelative riskPremenopausal womenIncident invasive breast cancerNurses' Health Study IIElevated breast cancer riskRed meatMultivariable relative risksAnimal fat intakeFood frequency questionnaireInvasive breast cancerConfidence intervalsCase-control studyDairy foodsPremenopausal yearsPostmenopausal womenProspective studyHighest quintileLowest quintile
2001
Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels.
Guillemette C, De Vivo I, Hankinson SE, Haiman CA, Spiegelman D, Housman DE, Hunter DJ. Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels. Cancer Epidemiology Biomarkers & Prevention 2001, 10: 711-4. PMID: 11401924.Peer-Reviewed Original ResearchConceptsHealth Study cohortBreast cancer riskHormone levelsBreast cancerUGT1A1 genotypeCancer riskNurses' Health Study cohortPremenopausal breast cancer riskUDP-glucuronosyltransferasesBody mass indexCase-control studyPlasma hormone levelsUGT1A1 promoter polymorphismCommon insertion/deletion polymorphismInsertion/deletion polymorphismPostmenopausal womenHormone replacementMass indexStudy cohortEstradiol levelsEstradiol metabolismBlood drawCaucasian womenRelative riskAfrican American population
2000
Dietary fat intake and endogenous sex steroid hormone levels in postmenopausal women.
Holmes M, Spiegelman D, Willett W, Manson J, Hunter D, Barbieri R, Colditz G, Hankinson S. Dietary fat intake and endogenous sex steroid hormone levels in postmenopausal women. Journal Of Clinical Oncology 2000, 18: 3668-76. PMID: 11054440, DOI: 10.1200/jco.2000.18.21.3668.Peer-Reviewed Original ResearchConceptsDietary fat intakeFat intakePostmenopausal womenInverse associationHormone levelsSex steroid hormone levelsHealthy postmenopausal womenTotal fat intakeFood frequency questionnaireEndogenous estrogen levelsBreast cancer riskOmega-3 fatsSex steroid hormonesCross-sectional associationsSteroid hormone levelsPercentage of energyEstradiol levelsEstrogen levelsPlasma sex steroidsPlasma levelsSex steroidsCancer riskProtein intakeEnergy intakeSteroid hormonesA prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk.
Hines LM, Hankinson SE, Smith-Warner SA, Spiegelman D, Kelsey KT, Colditz GA, Willett WC, Hunter DJ. A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk. Cancer Epidemiology Biomarkers & Prevention 2000, 9: 1099-105. PMID: 11045794.Peer-Reviewed Original ResearchConceptsBreast cancer riskAlcohol dehydrogenase type 3Hormone levelsCancer riskSteroid hormone levelsAlcohol intakeAlcohol consumptionADH3 genotypeHealth StudyADH3 polymorphismIncident breast cancer casesSex hormone-binding globulinOverall breast cancer riskPlasma steroid hormone levelsNurses' Health StudyHormone-binding globulinPartial Pearson correlation coefficientsCase-control studyConditional logistic regressionBreast cancer casesPostmenopausal womenProspective studyDehydroepiandrosterone sulfateRelative riskBreast cancerPooled Analysis of Prospective Cohort Studies on Height, Weight, and Breast Cancer Risk
van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, Fraser G, Goldbohm RA, Graham S, Kushi L, Marshall JR, Miller AB, Rohan T, Smith-Warner SA, Speizer FE, Willett WC, Wolk A, Hunter DJ. Pooled Analysis of Prospective Cohort Studies on Height, Weight, and Breast Cancer Risk. American Journal Of Epidemiology 2000, 152: 514-527. PMID: 10997541, DOI: 10.1093/aje/152.6.514.Peer-Reviewed Original ResearchConceptsBody mass indexProspective cohort studyPostmenopausal womenRelative riskPremenopausal womenBreast cancerRisk factorsCohort studyIncident invasive breast cancer casesBreast cancer risk factorsInvasive breast cancer casesIndependent risk factorPooled relative riskPostmenopausal breast cancerCancer risk factorsBreast cancer variesBreast cancer riskBreast cancer casesMenopausal statusCancer variesMass indexAnthropometric indicesCancer casesCancer riskWeight control
1999
Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age.
Garland M, Hunter DJ, Colditz GA, Spiegelman DL, Manson JE, Stampfer MJ, Willett WC. Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 1017-21. PMID: 10566558.Peer-Reviewed Original ResearchConceptsBreast cancer riskMultivariate relative riskAlcohol consumptionCancer riskRelative riskBreast cancerDrinks/weekInvasive breast cancerModerate alcohol consumptionMore drinks/weekAverage lifetime alcohol consumptionLifetime alcohol consumptionWomen age 25Past alcohol consumptionYears of agePostmenopausal womenPremenopausal womenWomen 25Age 25Young womenHeavy drinkingAge 23Drinking levelsWomenFurther studiesAssociation of age and reproductive factors with benign breast tissue composition.
Gertig DM, Stillman IE, Byrne C, Spiegelman D, Schnitt SJ, Connolly JL, Colditz GA, Hunter DJ. Association of age and reproductive factors with benign breast tissue composition. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 873-9. PMID: 10548315.Peer-Reviewed Original ResearchConceptsStromal proportionProliferative breast diseaseBreast diseaseRisk factorsBreast tissue compositionEpithelial proportionHealth StudyReproductive breast cancer risk factorsBenign breast biopsy slidesBreast cancer risk factorsObvious mass lesionStromal breast tissueNurses' Health StudyReproductive risk factorsCancer risk factorsBenign breast biopsyBreast cancer riskCase-control studyAssociation of agePostmenopausal parous womenFibrous stromal tissueNonproliferative breast diseasePostmenopausal womenPremenopausal womenParous womenRelationship between Serum Estradiol Levels and the Increases in High-Density Lipoprotein Levels in Postmenopausal Women Treated with Oral Estradiol1
Walsh B, Spiegelman D, Morrissey M, Sacks F. Relationship between Serum Estradiol Levels and the Increases in High-Density Lipoprotein Levels in Postmenopausal Women Treated with Oral Estradiol1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 985-989. PMID: 10084583, DOI: 10.1210/jcem.84.3.5571.Peer-Reviewed Original ResearchConceptsHigh-density lipoprotein levelsSerum estradiol levelsPostmenopausal womenLipoprotein levelsEstradiol levelsEstradiol 1Women
1998
Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women
Hankinson S, Willett W, Manson J, Colditz G, Hunter D, Spiegelman D, Barbieri R, Speizer F. Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women. Journal Of The National Cancer Institute 1998, 90: 1292-1299. PMID: 9731736, DOI: 10.1093/jnci/90.17.1292.Peer-Reviewed Original ResearchConceptsSex steroid hormone levelsHormone replacement therapyBreast cancer riskPostmenopausal womenBreast cancerSteroid hormone levelsBlood collectionEstrogen levelsReplacement therapyHormone levelsCancer riskHealth StudyPrevious hormone replacement therapyPlasma sex steroid hormone levelsPostmenopausal estrogen levelsNurses' Health StudyPlasma estrogen levelsLevels of estradiolCase-control studyPlasma androgen levelsBioavailable estradiolMenopausal statusSignificant positive associationControl subjectsLowest quartile
1997
Geographic Variation in Breast Cancer Incidence Rates in a Cohort of U.S. Women
Laden F, Hankinson S, Spiegelman D, Neas L, Colditz G, Hunter D, Manson J, Byrne C, Rosner B, Speizer F. Geographic Variation in Breast Cancer Incidence Rates in a Cohort of U.S. Women. Journal Of The National Cancer Institute 1997, 89: 1373-1378. PMID: 9308708, DOI: 10.1093/jnci/89.18.1373.Peer-Reviewed Original ResearchConceptsBreast cancer incidence ratesCancer incidence ratesHealth Study cohortRisk factorsIncidence ratePostmenopausal womenRelative riskHealth StudyNurses' Health Study cohortAge-adjusted breast cancer incidence ratesBreast cancer risk factorsNurses' Health StudyMultivariate-adjusted analysesAge-adjusted riskBreast cancer incidenceInvasive breast cancerBreast cancer mortalityCancer risk factorsPremenopausal womenStudy cohortIncident casesCancer mortalityExcess riskCancer incidenceBreast cancer
1995
Reproducibility of plasma hormone levels in postmenopausal women over a 2-3-year period.
Hankinson SE, Manson JE, Spiegelman D, Willett WC, Longcope C, Speizer FE. Reproducibility of plasma hormone levels in postmenopausal women over a 2-3-year period. Cancer Epidemiology Biomarkers & Prevention 1995, 4: 649-54. PMID: 8547832.Peer-Reviewed Original ResearchConceptsSex hormone-binding globulinIntraclass correlation coefficientPlasma hormone levelsPostmenopausal womenBioavailable estradiolPlasma levelsFree estradiolHormone levelsHealthy postmenopausal womenHormone-binding globulinLow intraclass correlation coefficientsPostmenopausal hormonesPlasma estrogenPlasma hormonesEstrone sulfateAge 51Blood samplesEstradiolWomenHormoneAndrostenedioneProlactinAgeSample collectionMenopause
1992
Dietary Fat and Fiber in Relation to Risk of Breast Cancer: An 8-Year Follow-up
Willett W, Hunter D, Stampfer M, Colditz G, Manson J, Spiegelman D, Rosner B, Hennekens C, Speizer F. Dietary Fat and Fiber in Relation to Risk of Breast Cancer: An 8-Year Follow-up. JAMA 1992, 268: 2037-2044. DOI: 10.1001/jama.1992.03490150089030.Peer-Reviewed Original ResearchTotal fat intakeBreast cancer incidenceFat intakeBreast cancerPostmenopausal womenCancer incidenceProtective effectHealth StudySelf-administered food frequency questionnaireEnergy intakePositive associationDietary fat increasesNurses' Health StudyProspective cohort studyFood frequency questionnaireTotal energy intakeMiddle-aged womenYears of ageDietary questionnaireCohort studyFrequency questionnaireIncident casesRisk factorsDietary fatCorresponding RRsDietary fat and fiber in relation to risk of breast cancer. An 8-year follow-up.
Willett WC, Hunter DJ, Stampfer MJ, Colditz G, Manson JE, Spiegelman D, Rosner B, Hennekens CH, Speizer FE. Dietary fat and fiber in relation to risk of breast cancer. An 8-year follow-up. JAMA 1992, 268: 2037-44. PMID: 1328696, DOI: 10.1001/jama.268.15.2037.Peer-Reviewed Original ResearchConceptsTotal fat intakeBreast cancer incidenceFat intakeBreast cancerPostmenopausal womenCancer incidenceProtective effectHealth StudySelf-administered food frequency questionnaireEnergy intakePositive associationDietary fat increasesNurses' Health StudyProspective cohort studyFood frequency questionnaireTotal energy intakeMiddle-aged womenYears of ageDietary questionnaireCohort studyFrequency questionnaireIncident casesRisk factorsDietary fatCorresponding RRs