2024
Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study
Puklin L, Irwin M, Sanft T, Ferrucci L, Harrigan M, McGowan C, Cartmel B, Zupa M, Winer E, Deyling M, Ligibel J, Basen-Engquist K, Spiegelman D, Sharifi M. Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study. Supportive Care In Cancer 2024, 32: 590. PMID: 39141176, DOI: 10.1007/s00520-024-08789-5.Peer-Reviewed Original ResearchConceptsPhysical activityLifestyle interventionSelf-reported PA questionnaireSelf-reported diet qualityBreast cancerHealthy Eating Index-2015Stage I-III breast cancerBenefits of PASequential mixed methods studyI-III breast cancerChemotherapy-related symptomsMixed methods studyThematic content analysisBehavioral goalsSense of controlBody mass indexPA questionnaireSemi-structured interviewsMean body mass indexTranscribed verbatimIntervention armTailored educationDiet qualityNutritional behaviorMental benefitsImproving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial
Puklin L, Ferrucci L, Harrigan M, McGowan C, Zupa M, Cartmel B, Li F, Ligibel J, Spiegelman D, Sharifi M, Sanft T, Irwin M. Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial. Cancer 2024, 130: 2440-2452. PMID: 38470431, PMCID: PMC11214600, DOI: 10.1002/cncr.35280.Peer-Reviewed Original ResearchPhysical activityDiet qualityHEI-2015Strength trainingLifestyle behaviorsHealthy Eating Index (HEI)-2015Breast cancerAssociated with baseline fatigueImprove physical activityImprove lifestyle behaviorsHigher HEI-2015Associated with higher oddsExercise interventionUsual careIntervention armIntervention groupBaseline fatigueLifestyle interventionYearlong interventionLower fatigueHigher oddsSecondary analysisLogistic regressionNewly diagnosed patientsStudy arms
2023
Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors
Puklin L, Harrigan M, Cartmel B, Sanft T, Gottlieb L, Zhou B, Ferrucci L, Li F, Spiegelman D, Sharifi M, Irwin M. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers 2023, 15: 4719. PMID: 37835412, PMCID: PMC10571774, DOI: 10.3390/cancers15194719.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsLifestyle interventionPhysical activityQuality of lifeBody weightWaitlist groupDiet qualitySelf-reported body weightWeight lossFavorable weight changeHealthy weight lossBody mass indexHealthy body weightGreater weight lossEvidence-based materialsDiverse healthcare settingsIntervention armMass indexClinical practicePositive behavior changeHealthcare settingsSurvivorsWeight changeInterventionMediation analysis in the presence of continuous exposure measurement error
Cheng C, Spiegelman D, Li F. Mediation analysis in the presence of continuous exposure measurement error. Statistics In Medicine 2023, 42: 1669-1686. PMID: 36869626, PMCID: PMC11320713, DOI: 10.1002/sim.9693.Peer-Reviewed Original ResearchConceptsBody mass indexExposure measurement errorPhysical activityMediation proportionHealth Professionals FollowCardiovascular disease incidenceProfessionals FollowMediation analysisMass indexCardiovascular diseaseLower riskStudy designEffect estimatesValidation study designContinuous exposureBiased effect estimatesTrue exposureMediatorsExposureValidation studyBinary outcomesHealth science studiesOutcomesRiskDisease incidence
2004
Physical activity and risk of coronary heart disease in India
Rastogi T, Vaz M, Spiegelman D, Reddy KS, Bharathi A, Stampfer MJ, Willett WC, Ascherio A. Physical activity and risk of coronary heart disease in India. International Journal Of Epidemiology 2004, 33: 759-767. PMID: 15044412, DOI: 10.1093/ije/dyh042.Peer-Reviewed Original ResearchConceptsLeisure-time exerciseCHD riskRisk factorsPhysical activityPhysical exerciseSedentary activitiesHospital-based case-control studyCoronary heart disease riskDisease riskHeart disease riskCoronary heart diseaseAcute myocardial infarctionRisk of CHDSex-adjusted analysesCase-control studyConditional logistic regressionPhysical inactivity levelsMultivariate adjustmentBrisk walkingMyocardial infarctionHeart diseaseRelative riskSedentary lifestyleElevated riskMultivariate analysis
2003
Dietary Fiber Reduces Peripheral Arterial Disease Risk in Men
Merchant AT, Hu FB, Spiegelman D, Willett WC, Rimm EB, Ascherio A. Dietary Fiber Reduces Peripheral Arterial Disease Risk in Men. Journal Of Nutrition 2003, 133: 3658-3663. PMID: 14608090, DOI: 10.1093/jn/133.11.3658.Peer-Reviewed Original ResearchConceptsPeripheral arterial disease riskCereal fiber intakeArterial disease riskPAD riskFiber intakeInverse associationDisease riskEarly coronary heart diseaseIncident PAD casesFood frequency questionnaireCoronary heart diseaseTotal fiber intakeOverall inverse associationDisease QuestionnaireFrequency questionnaireLowest quintileHeart diseaseCardiovascular diseaseFamily historyPhysical activityPAD casesAlcohol consumptionEnergy intakeIntakeRiskProspective study of the association of changes in dietary intake, physical activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men
Koh-Banerjee P, Chu NF, Spiegelman D, Rosner B, Colditz G, Willett W, Rimm E. Prospective study of the association of changes in dietary intake, physical activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men. American Journal Of Clinical Nutrition 2003, 78: 719-727. PMID: 14522729, DOI: 10.1093/ajcn/78.4.719.Peer-Reviewed Original ResearchConceptsWaist gainMetabolic equivalent taskWaist circumferenceAssociation of changesPhysical activityUS menAlcohol consumptionLifestyle factorsTrans fatsBody mass indexFiber/dVigorous physical activityAbdominal adipose tissueAbdominal obesityProspective cohortMass indexProspective studySmoking cessationProspective dataChronic diseasesDietary intakeSelf-report questionnairesAdipose tissueFiber consumptionEnergy intakeA Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women
Kroenke CH, Chu NF, Rifai N, Spiegelman D, Hankinson SE, Manson JE, Rimm EB. A Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women. Diabetes Care 2003, 26: 1971-1978. PMID: 12832298, DOI: 10.2337/diacare.26.7.1971.Peer-Reviewed Original ResearchConceptsHealth Study IIGlycemic controlAlcohol intakeBiologic markersNurses' Health Study IIBeneficial glycemic effectsAverage alcohol intakeModerate alcohol consumptionMain outcome measuresCross-sectional studyYears of ageAlcohol consumption patternsOverweight womenGlycemic effectsInsulin levelsLifestyle factorsInsulin resistanceDietary factorsInverse associationC-peptideAverage daily consumptionOutcome measuresPhysical activityBlood samplesAlcohol consumption
2002
Physical Activity, Body Mass Index, and Ovulatory Disorder Infertility
Rich-Edwards JW, Spiegelman D, Garland M, Hertzmark E, Hunter DJ, Colditz GA, Willett WC, Wand H, Manson JE. Physical Activity, Body Mass Index, and Ovulatory Disorder Infertility. Epidemiology 2002, 13: 184-190. PMID: 11880759, DOI: 10.1097/00001648-200203000-00013.Peer-Reviewed Original ResearchConceptsBody mass indexOvulatory disorder infertilityHealth Study IIOvulatory infertilityRelative riskMass indexVigorous activityNurses' Health Study IIVigorous-intensity exerciseLower relative riskAmerican womenAdiposity levelsIntensity exercisePhysical activitySedentary lifestyleBMI distributionInfertilityU.S. womenStudy IIWomenUnderweightRiskWeekly activitiesAssociationHours
2001
Assessment of Questionnaire Validity for Measuring Total Fat Intake using Plasma Lipid Levels as Criteria
Willett W, Stampfer M, Chu NF, Spiegelman D, Holmes M, Rimm E. Assessment of Questionnaire Validity for Measuring Total Fat Intake using Plasma Lipid Levels as Criteria. American Journal Of Epidemiology 2001, 154: 1107-1112. PMID: 11744515, DOI: 10.1093/aje/154.12.1107.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkersBody Mass IndexBody WeightCholesterol, HDLCohort StudiesCross-Sectional StudiesDiet SurveysDietary FatsDietary FiberDietary ProteinsEnergy IntakeExerciseFastingFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRegression AnalysisReproducibility of ResultsSmokingSurveys and QuestionnairesTriglyceridesConceptsTotal fat intakeFood frequency questionnaireFat intakeTriglyceride levelsFrequency questionnaireDietary fatSemiquantitative food frequency questionnaireHealth Professionals FollowBody mass indexHigh fat intakePlasma lipid levelsMetabolic studiesIntake of proteinCross-sectional analysisProfessionals FollowOverweight menMass indexInverse associationLipid levelsPhysical activityBlood specimensAlcohol consumptionSpecific biomarkersIntakeMultiple regression analysisRelationship of a large weight loss to long-term weight change among young and middle-aged US women
Field A, Wing R, Manson J, Spiegelman D, Willett W. Relationship of a large weight loss to long-term weight change among young and middle-aged US women. International Journal Of Obesity 2001, 25: 1113-1121. PMID: 11477495, DOI: 10.1038/sj.ijo.0801643.Peer-Reviewed Original ResearchConceptsHealth Study IIWeight lossPhysical activityNurses' Health Study IILong-term weight changeLong-term weight gainCategories of BMIBody mass indexLarge weight lossVigorous physical activityMiddle-aged womenSignificant weight lossSelf-reported weightDiagnosis of cancerMass indexWeight cyclingDietary intakeCardiovascular diseaseLess weightUS womenMost womenInactive peersBMIWeight gainStudy IIDietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men
Chu N, Stampfer M, Spiegelman D, Rifai N, Hotamisligil G, Rimm E. Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men. International Journal Of Obesity 2001, 25: 106-114. PMID: 11244465, DOI: 10.1038/sj.ijo.0801468.Peer-Reviewed Original ResearchConceptsBody mass indexPlasma leptin concentrationsLow plasma leptin concentrationsBody fat massLeptin concentrationsPhysical activityNormal weightOverweight menFat intakeLifestyle factorsFat massBlood samplesConfounding variablesWeight gainMonounsaturated fat intakeY weight gainRecent prospective studiesVenous blood samplesCurrent smokingObese menCholesterol intakeObese subjectsMass indexPlasma leptinProspective study
2000
Leisure-Time Physical Activity, Television Watching, and Plasma Biomarkers of Obesity and Cardiovascular Disease Risk
Fung TT, Hu FB, Yu J, Chu NF, Spiegelman D, Tofler GH, Willett WC, Rimm EB. Leisure-Time Physical Activity, Television Watching, and Plasma Biomarkers of Obesity and Cardiovascular Disease Risk. American Journal Of Epidemiology 2000, 152: 1171-1178. PMID: 11130623, DOI: 10.1093/aje/152.12.1171.Peer-Reviewed Original ResearchConceptsLeisure-time physical activityDensity lipoprotein cholesterolPhysical activityCVD riskLipoprotein cholesterolHDL cholesterolCardiovascular diseaseTelevision watchingLong-term leisure-time physical activityHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolLong-term physical activityMale health professionalsBiomarkers of obesityCardiovascular disease riskBlood lipidsThrombogenic factorsLeptin levelsInsulin sensitivityC-peptideApolipoprotein A1Vigorous activityLinear regression analysisBiochemical markersHealth professionals
1999
Recreational Physical Activity and the Risk of Cholecystectomy in Women
Leitzmann M, Rimm E, Willett W, Spiegelman D, Grodstein F, Stampfer M, Colditz G, Giovannucci E. Recreational Physical Activity and the Risk of Cholecystectomy in Women. New England Journal Of Medicine 1999, 341: 777-784. PMID: 10477775, DOI: 10.1056/nejm199909093411101.Peer-Reviewed Original ResearchConceptsRisk of cholecystectomyRecreational physical activityMultivariate relative riskPhysical activityGallstone diseaseRelative riskSedentary behaviorHealth StudyBody weightCases of cholecystectomyRecent weight lossNurses' Health StudyYears of ageSymptomatic cholelithiasisDecreased riskLowest quintileRisk factorsCholecystectomyWeight lossWeight changeWomenDiseaseActivity levelsWeeksRisk
1998
A prospective study of physical activity and prostate cancer in male health professionals.
Giovannucci E, Leitzmann M, Spiegelman D, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. A prospective study of physical activity and prostate cancer in male health professionals. Cancer Research 1998, 58: 5117-22. PMID: 9823321.Peer-Reviewed Original ResearchConceptsMale health professionalsTotal prostate cancerMetastatic prostate cancerProstate cancerPhysical activityMetabolic equivalentsVigorous activityLower riskHealth professionalsLeisure-time physical activityMore metabolic equivalentsNonvigorous physical activityReported average timeHealth Professionals FollowHistory of diabetesProspective cohort studyAdvanced prostate cancerRole of exerciseTime physical activityYears of ageWarrants further studyNonvigorous activitiesMen 40Professionals FollowCohort studyPhysical Activity and Breast Cancer Risk in a Cohort of Young Women
Rockhill B, Willett W, Hunter D, Manson J, Hankinson S, Spiegelman D, Colditz G. Physical Activity and Breast Cancer Risk in a Cohort of Young Women. Journal Of The National Cancer Institute 1998, 90: 1555-1160. PMID: 9701365, DOI: 10.1093/jnci/90.15.1155.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study IIPhysical activityRelative riskBreast cancerCancer riskNurses' Health Study IIRR of cancerBreast cancer preventionInvasive breast cancerStrenuous physical activityConfidence intervalsLate adolescenceNonoccupational physical activityYoung adult womenProspective studyNonoccupational activitiesActive womenCancer preventionReduced riskStrenuous activityAdult womenAge 18Logistic regressionYoung womenThe relation of physical activity to risk for symptomatic gallstone disease in men.
Leitzmann MF, Giovannucci EL, Rimm EB, Stampfer MJ, Spiegelman D, Wing AL, Willett WC. The relation of physical activity to risk for symptomatic gallstone disease in men. Annals Of Internal Medicine 1998, 128: 417-25. PMID: 9499324, DOI: 10.7326/0003-4819-128-6-199803150-00001.Peer-Reviewed Original ResearchConceptsSymptomatic gallstone diseaseGallstone diseasePhysical activityYears of ageSymptomatic gallstonesBody weightU.S. male health professionalsMale health professionalsProspective cohort studyUse of medicationsMen 65 yearsStrong inverse associationBiliary eventsMen 40Cohort studySmoking habitsExtreme quintilesAlcohol intakeRecent symptomsInverse associationMultiple confoundersMedical conditionsSedentary behaviorHigh riskHealth professionalsCan behavioral risk factors explain the difference in body mass index between African-American and European-American women?
Holmes MD, Stampfer MJ, Wolf AM, Jones CP, Spiegelman D, Manson JE, Colditz GA. Can behavioral risk factors explain the difference in body mass index between African-American and European-American women? Ethnicity & Disease 1998, 8: 331-9. PMID: 9926903.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexAfrican American womenEuropean American womenMass indexIntentional weight lossMeasurements of dietBehavioral risk factorsModifiable reasonsRisk factorsPhysical activityCalorie intakeFemale nursesAge 18Weight lossMultivariate determinantsWomenTelevision watchingMarital statusBehavioral factorsAfrican AmericansWeight differencesOccupation groupsAgeLinear regression
1997
Calcium Intake and the Incidence of Forearm and Hip Fractures among Men 1 , 2
Owusu W, Willett W, Feskanich D, Ascherio A, Spiegelman D, Colditz G. Calcium Intake and the Incidence of Forearm and Hip Fractures among Men 1 , 2. Journal Of Nutrition 1997, 127: 1782-1787. PMID: 9278560, DOI: 10.1093/jn/127.9.1782.Peer-Reviewed Original ResearchConceptsIncidence of forearmCalcium intakeBody mass indexHip fractureRelative riskForearm fracturesComparable relative riskHealth Professionals FollowHigh calcium intakeTotal energy intakeRisk of fractureGlass of milkMen 40Professionals FollowModerate traumaMass indexSmoking statusLifestyle factorsHighest quintileLowest quintileEpidemiologic studiesPhysical activityLower riskAlcohol consumptionEnergy intakeLeisure-Time Physical Activity, Body Size, and Colon Cancer in Women
Martínez M, Giovannucci E, Spiegelman D, Willett W, Hunter D, Colditz G. Leisure-Time Physical Activity, Body Size, and Colon Cancer in Women. Journal Of The National Cancer Institute 1997, 89: 948-955. PMID: 9214674, DOI: 10.1093/jnci/89.13.948.Peer-Reviewed Original ResearchConceptsLeisure-time physical activityBody mass indexMass indexPhysical activityColon cancerRelative riskProspective studyHealth StudyHigher body mass indexHigh colon cancer riskMajor medical eventsNurses' Health StudyMedical risk factorsBody fat distributionSignificant inverse associationColon cancer incidenceColon cancer riskLean body weightHospital recordsHip ratioPhysical inactivityMetabolic equivalentsWeek scoresRisk factorsCancer incidence