2022
Effect modification by sex for associations of fine particulate matter (PM2.5) with cardiovascular mortality, hospitalization, and emergency room visits: systematic review and meta-analysis
Heo S, Son JY, Lim CC, Fong KC, Choi HM, Hernandez-Ramirez RU, Nyhan K, Dhillon PK, Kapoor S, Prabhakaran D, Spiegelman D, Bell ML. Effect modification by sex for associations of fine particulate matter (PM2.5) with cardiovascular mortality, hospitalization, and emergency room visits: systematic review and meta-analysis. Environmental Research Letters 2022, 17: 053006. PMID: 35662857, PMCID: PMC9162078, DOI: 10.1088/1748-9326/ac6cfb.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCardiovascular diseaseRisk ratioCVD mortalityEffect modificationObservational studyLong-term exposureSystematic reviewIschemic heart diseaseAcute myocardial infarctionQuality of evidenceMeeting inclusion criteriaDifferent risksLong-term PMShort-term PMEffects of PMCurrent observational studyRecommendations AssessmentCardiovascular mortalityCardiovascular riskCVD outcomesCVD riskHeart failureCardiac arrestMyocardial infarctionSubgroup analysis
2020
The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk
Spiegelman D, Lovato LC, Khudyakov P, Wilkens TL, Adebamowo CA, Adebamowo SN, Appel LJ, Beulens JW, Coughlin JW, Dragsted LO, Edenberg HJ, Eriksen JN, Estruch R, Grobbee DE, Gulayin PE, Irazola V, Krystal JH, Lazo M, Murray MM, Rimm EB, Schrieks IC, Williamson JD, Mukamal KJ. The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk. European Journal Of Preventive Cardiology 2020, 27: 1967-1982. PMID: 32250171, PMCID: PMC7541556, DOI: 10.1177/2047487320912376.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionCardiovascular Health TrialAlcohol consumptionHealth trialsCardiovascular diseaseModerate alcoholNon-fatal ischemic strokeNon-fatal myocardial infarctionPrimary composite endpointCongestive heart failureCoronary heart diseaseModerate alcohol consumersAdults 50 yearsPublic health guidelinesAlcohol use disorderPreferred alcoholic beverageCardiometabolic effectsCardiometabolic riskCarotid revascularizationIschemic strokeSecondary outcomesComposite endpointHeart failurePrimary outcomeMyocardial infarctionEstimation in the Cox survival regression model with covariate measurement error and a changepoint
Agami S, Zucker DM, Spiegelman D. Estimation in the Cox survival regression model with covariate measurement error and a changepoint. Biometrical Journal 2020, 62: 1139-1163. PMID: 32003495, DOI: 10.1002/bimj.201800085.Peer-Reviewed Original ResearchConceptsSystolic blood pressure levelsChronic air pollution exposureCox survival regression modelFatal myocardial infarctionBlood pressure levelsCardiovascular disease deathsCox regression modelAir pollution exposureRegression modelsDisease deathsMyocardial infarctionRelative riskStandard Cox modelSurvival regression modelsCox modelPollution exposureSurvival endpointsCovariates of interest
2011
Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study
Wu J, Lemaitre RN, Imamura F, King IB, Song X, Spiegelman D, Siscovick DS, Mozaffarian D. Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study. American Journal Of Clinical Nutrition 2011, 94: 431-438. PMID: 21697077, PMCID: PMC3142722, DOI: 10.3945/ajcn.111.012054.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseNonfatal myocardial infarctionSudden cardiac arrestFatal coronary heart diseaseTotal coronary heart diseaseIncident coronary heart diseaseDe novo lipogenesisHigh riskCHD eventsHeart diseaseMultivariable-adjusted Cox proportional hazardsCommunity-based prospective studySecondary analysisCardiovascular disease risk factorsCardiovascular Health StudyDisease risk factorsFatty acidsCox proportional hazardsDe novo lipogenesis pathwayCHD deathCHD outcomesProspective studyCardiac arrestMyocardial infarctionMedical records
2005
Bidi and cigarette smoking and risk of acute myocardial infarction among males in urban India
Rastogi T, Jha P, Reddy KS, Prabhakaran D, Spiegelman D, Stampfer MJ, Willett WC, Ascherio A. Bidi and cigarette smoking and risk of acute myocardial infarction among males in urban India. Tobacco Control 2005, 14: 356. PMID: 16183987, PMCID: PMC1748103, DOI: 10.1136/tc.2005.011965.Peer-Reviewed Original ResearchAlcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status
Hines LM, Hunter DJ, Stampfer MJ, Spiegelman D, Chu NF, Rifai N, Hankinson SE, Rimm EB. Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status. Atherosclerosis 2005, 182: 293-300. PMID: 16051248, DOI: 10.1016/j.atherosclerosis.2005.02.005.Peer-Reviewed Original ResearchConceptsHigh-density lipoprotein levelsPostmenopausal hormonesPostmenopausal womenModerate alcohol consumptionHDL levelsOlder-aged menPremenopausal womenAlcohol consumptionADH1C genotypeLipoprotein levelsAged menCoronary heart diseaseMenopausal statusExogenous estrogenMyocardial infarctionHeart diseaseModerate drinkersOlder menFunctional polymorphismsWomenType 1CMenVaried exposureAssociationHigh levels
2004
Physical activity and risk of coronary heart disease in India
Rastogi T, Vaz M, Spiegelman D, Reddy KS, Bharathi A, Stampfer MJ, Willett WC, Ascherio A. Physical activity and risk of coronary heart disease in India. International Journal Of Epidemiology 2004, 33: 759-767. PMID: 15044412, DOI: 10.1093/ije/dyh042.Peer-Reviewed Original ResearchConceptsLeisure-time exerciseCHD riskRisk factorsPhysical activityPhysical exerciseSedentary activitiesHospital-based case-control studyCoronary heart disease riskDisease riskHeart disease riskCoronary heart diseaseAcute myocardial infarctionRisk of CHDSex-adjusted analysesCase-control studyConditional logistic regressionPhysical inactivity levelsMultivariate adjustmentBrisk walkingMyocardial infarctionHeart diseaseRelative riskSedentary lifestyleElevated riskMultivariate analysisDiet and risk of ischemic heart disease in India
Rastogi T, Reddy KS, Vaz M, Spiegelman D, Prabhakaran D, Willett WC, Stampfer MJ, Ascherio A. Diet and risk of ischemic heart disease in India. American Journal Of Clinical Nutrition 2004, 79: 582-592. PMID: 15051601, DOI: 10.1093/ajcn/79.4.582.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseServings/wkIHD riskLower riskHeart diseaseInverse associationHospital-based case-control studyDose-dependent inverse associationLong-term dietary intakeFood frequency questionnaireAcute myocardial infarctionCase-control studyConditional logistic regressionPredictors of riskLower relative riskAlpha-linolenic acidBasis of ageMustard oilGreen leafy vegetablesMyocardial infarctionVegetable intakeLeading causeDietary intakeCereal intakeRelative risk
2003
High 18:2 Trans-Fatty Acids in Adipose Tissue Are Associated with Increased Risk of Nonfatal Acute Myocardial Infarction in Costa Rican Adults
Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H. High 18:2 Trans-Fatty Acids in Adipose Tissue Are Associated with Increased Risk of Nonfatal Acute Myocardial Infarction in Costa Rican Adults. Journal Of Nutrition 2003, 133: 1186-1191. PMID: 12672941, DOI: 10.1093/jn/133.4.1186.Peer-Reviewed Original ResearchConceptsRisk of MICoronary heart diseaseMyocardial infarctionAdipose tissueTrans fatty acidsOdds ratioNonfatal acute myocardial infarctionTrans fatty acid intakeFirst nonfatal myocardial infarctionConditional logistic regression modelsNonfatal myocardial infarctionTrans FACosta Rican adultsAcute myocardial infarctionTotal adipose tissueAdipose tissue samplesArea of residenceIndividual trans fatty acidsLogistic regression modelsIncreased riskIncident casesAcid intakeRisk factorsAtherogenic potentialHeart diseaseAdipose Tissue α-Linolenic Acid and Nonfatal Acute Myocardial Infarction in Costa Rica
Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H. Adipose Tissue α-Linolenic Acid and Nonfatal Acute Myocardial Infarction in Costa Rica. Circulation 2003, 107: 1586-1591. PMID: 12668490, DOI: 10.1161/01.cir.0000058165.81208.c6.Peer-Reviewed Original ResearchConceptsNonfatal acute myocardial infarctionAcute myocardial infarctionAdipose tissue alpha-linolenic acidAlpha-linolenic acidMyocardial infarctionCardiovascular diseaseFirst nonfatal acute myocardial infarctionMultivariate conditional logistic regression modelPopulation-based case-control studyConditional logistic regression modelsTissue linoleic acidMI risk factorsPopulation control subjectsCase-control studyAdipose tissue samplesArea of residenceLogistic regression modelsTrans fatty acidsΑ-Linolenic AcidCase patientsFatty acidsControl subjectsLowest quintileInverse associationRisk factors
2002
Dietary and Adipose Tissue Gamma-Tocopherol and Risk of Myocardial Infarction
El-Sohemy A, Baylin A, Spiegelman D, Ascherio A, Campos H. Dietary and Adipose Tissue Gamma-Tocopherol and Risk of Myocardial Infarction. Epidemiology 2002, 13: 216-223. PMID: 11880764, DOI: 10.1097/00001648-200203000-00018.Peer-Reviewed Original ResearchConceptsDietary vitamin EMyocardial infarctionGamma-tocopherolOdds ratioVitamin ENonfatal myocardial infarctionFood frequency questionnaireCoronary heart diseasePopulation-based studyFirst myocardial infarctionConfidence intervalsConditional logistic regressionAdipose tissue samplesHighest quintileSupplement usersLowest quintileHeart diseaseInverse associationDietary intakeLower riskSubstantial inverse associationMultivariate analysisLogistic regressionTissue samplesWeak association
2000
Prospective study of major dietary patterns and risk of coronary heart disease in men 1 , 2 , 3
Hu F, Rimm E, Stampfer M, Ascherio A, Spiegelman D, Willett W. Prospective study of major dietary patterns and risk of coronary heart disease in men 1 , 2 , 3. American Journal Of Clinical Nutrition 2000, 72: 912-921. PMID: 11010931, DOI: 10.1093/ajcn/72.4.912.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAlcohol DrinkingBody Mass IndexCohort StudiesCoronary DiseaseDietDiet RecordsDietary SupplementsExerciseFactor Analysis, StatisticalHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProportional Hazards ModelsProspective StudiesRisk FactorsSmokingSurveys and QuestionnairesConceptsCoronary heart diseaseFood frequency questionnaireMajor dietary patternsRisk of CHDDietary patternsHeart diseaseRelative riskHigh intakePattern scoresCases of CHDHigh-fat dairy productsPrudent pattern scoresWestern pattern scoreCHD risk factorsProspective cohort studyOverall dietary patternsBody mass indexPrudent patternCohort studyCigarette smokingMass indexProspective studyHighest quintileMyocardial infarctionSubgroup analysis
1999
Effects of Long‐Acting Versus Short‐Acting Calcium Channel Blockers Among Older Survivors of Acute Myocardial Infarction
Gillman M, Ross‐Degnan D, McLaughlin T, Gao X, Spiegelman D, Hertzmark E, Goldman L, Soumerai S. Effects of Long‐Acting Versus Short‐Acting Calcium Channel Blockers Among Older Survivors of Acute Myocardial Infarction. Journal Of The American Geriatrics Society 1999, 47: 512-517. PMID: 10323641, DOI: 10.1111/j.1532-5415.1999.tb02562.x.Peer-Reviewed Original ResearchConceptsCalcium channel blockersAcute myocardial infarctionShort-acting calcium channel blockersCardiac rehospitalizationMyocardial infarctionChannel blockersRelative riskOlder survivorsActing calcium channel blockerSeparate Cox regression modelsDihydropyridine calcium channel blockerRetrospective cohort studyCoronary heart diseaseDrug claims dataCox regression modelDrug benefit programCause mortalityClinical characteristicsCohort studyEligible subjectsRehospitalization ratesAdverse outcomesHeart diseaseOutcome measuresRehospitalization
1997
Adverse Outcomes of Underuse of β-Blockers in Elderly Survivors of Acute Myocardial Infarction
Soumerai S, McLaughlin T, Spiegelman D, Hertzmark E, Thibault G, Goldman L. Adverse Outcomes of Underuse of β-Blockers in Elderly Survivors of Acute Myocardial Infarction. JAMA 1997, 277: 115-121. DOI: 10.1001/jama.1997.03540260029031.Peer-Reviewed Original ResearchCalcium channel blockersCalcium channel blocker useΒ-blockersAdverse outcomesChannel blockersBlocker useEligible patientsMyocardial infarctionRelative riskMortality rateAcute myocardial infarction survivorsBaseline risk variablesCardiac hospital readmissionsElderly AMI survivorsΒ-blocker therapyΒ-blocker usePredictors of survivalRisk of deathRetrospective cohort designAcute myocardial infarctionDemonstrable adverse effectsMyocardial infarction survivorsNew β-blockerPrescription drug coverageMeasurable adverse outcomesAdverse outcomes of underuse of beta-blockers in elderly survivors of acute myocardial infarction.
Soumerai SB, McLaughlin TJ, Spiegelman D, Hertzmark E, Thibault G, Goldman L. Adverse outcomes of underuse of beta-blockers in elderly survivors of acute myocardial infarction. JAMA 1997, 277: 115-21. PMID: 8990335, DOI: 10.1001/jama.277.2.115.Peer-Reviewed Original ResearchConceptsCalcium channel blockersCalcium channel blocker useAdverse outcomesChannel blockersBlocker useEligible patientsMyocardial infarctionRelative riskMortality rateAcute myocardial infarction survivorsBaseline risk variablesCardiac hospital readmissionsElderly AMI survivorsBeta-blocker therapyBeta-blocker usePredictors of survivalRisk of deathRetrospective cohort designAcute myocardial infarctionDemonstrable adverse effectsMyocardial infarction survivorsPrescription drug coverageMeasurable adverse outcomesBeta blockersElderly patients
1996
Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States
Ascherio A, Rimm E, Giovannucci E, Spiegelman D, Meir S, Willett W. Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. The BMJ 1996, 313: 84. PMID: 8688759, PMCID: PMC2351515, DOI: 10.1136/bmj.313.7049.84.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHeart diseaseMyocardial infarctionFat intakeRisk factorsHealth professionalsFatal coronary heart diseaseNon-dietary risk factorsNon-fatal myocardial infarctionCohort questionnaire studyCoronary risk factorsMultivariate relative riskTotal fat intakeIntake of cholesterolAcute myocardial infarctionDiagnosed cardiovascular diseaseLinolenic acid intakeBlood cholesterol concentrationsIntake of fiberPositive associationCoronary deathCoronary eventsSpecific preventive effectCholesterol intakeCoronary diseaseVegetable, Fruit, and Cereal Fiber Intake and Risk of Coronary Heart Disease Among Men
Rimm EB, Ascherio A, Giovannucci E, Spiegelman D, Stampfer MJ, Willett WC. Vegetable, Fruit, and Cereal Fiber Intake and Risk of Coronary Heart Disease Among Men. JAMA 1996, 275: 447-451. PMID: 8627965, DOI: 10.1001/jama.1996.03530300031036.Peer-Reviewed Original ResearchConceptsTotal myocardial infarctionCoronary heart diseaseDietary fiber intakeMyocardial infarctionFiber intakeRelative riskCoronary diseaseHeart diseaseInverse associationCases of MIAge-adjusted relative riskTotal dietary fiber intakeDietary fiberCereal fiber intakeCardiovascular risk factorsNonfatal myocardial infarctionTotal energy intakeTotal fiber intakeCurrent national dietary guidelinesMain food contributorsFatal coronary diseaseYears of ageNational dietary guidelinesDietary questionnaireCohort study