2021
Impact of the Affordable Care Act on Colorectal Cancer Incidence and Mortality
Lee C, Kushi LH, Reed ME, Eldridge EH, Lee JK, Zhang J, Spiegelman D. Impact of the Affordable Care Act on Colorectal Cancer Incidence and Mortality. American Journal Of Preventive Medicine 2021, 62: 387-394. PMID: 34763959, PMCID: PMC8863627, DOI: 10.1016/j.amepre.2021.08.025.Peer-Reviewed Original ResearchConceptsColorectal cancer-related mortalityColorectal cancer incidenceCancer-related mortalityColorectal cancer outcomesAffordable Care ActCancer incidenceColorectal cancerCancer outcomesCare ActKaiser Permanente Northern California membersHealth plansColorectal cancer screeningInterrupted time series designRace/ethnicityCancer screeningCalifornia membersPreventive servicesPrivate health insurancePocket costsMortalityTime series designIncidenceCost sharingCancerComparison group
2020
Mortality under early access to antiretroviral therapy vs. Eswatini’s national standard of care: the MaxART clustered randomized stepped‐wedge trial
Chao A, Spiegelman D, Khan S, Walsh F, Mazibuko S, Pasipamire M, Chai B, Reis R, Mlambo K, Delva W, Khumalo G, Zwane M, Fleming Y, Mafara E, Hettema A, Lejeune C, Bärnighausen T, Okello V. Mortality under early access to antiretroviral therapy vs. Eswatini’s national standard of care: the MaxART clustered randomized stepped‐wedge trial. HIV Medicine 2020, 21: 429-440. PMID: 32458567, DOI: 10.1111/hiv.12876.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyMortality rateDisease-related mortality rateCox proportional hazards modelCause mortality ratesStepped-wedge trialProportional hazards modelStepped-wedge designQuality of lifeEvidence of harmClinic transitionSecondary outcomesSOC participantsHealth clinicsLong-term consequencesImplementation trialHazards modelHIVStudy participantsMortalityHealth systemDecrease infectionEarly accessClinicTherapy
2016
Survival analysis with measurement error in a cumulative exposure variable: radon progeny in relation to lung cancer mortality
Spiegelman* D, Khudyakov P, Samet J, Wiggins C, Liao X, Meisner A. Survival analysis with measurement error in a cumulative exposure variable: radon progeny in relation to lung cancer mortality. ISEE Conference Abstracts 2016, 2016 DOI: 10.1289/isee.2016.2988.Peer-Reviewed Original Research
2014
The Association of Long-Term Exposure to PM2.5 on All-Cause Mortality in the Nurses’ Health Study and the Impact of Measurement-Error Correction
Hart* J, Liao X, Hong B, Puett R, Yanosky J, Suh H, Kioumourtzoglou M, Spiegelman D, Laden F. The Association of Long-Term Exposure to PM2.5 on All-Cause Mortality in the Nurses’ Health Study and the Impact of Measurement-Error Correction. ISEE Conference Abstracts 2014, 2014 DOI: 10.1289/isee.2014.p2-430.Peer-Reviewed Original Research
2011
AN APPLICATION OF A RISK SET CALIBRATION METHOD TO A STUDY OF AIR POLLUTION EFFECTS ON ALL CAUSE MORTALITY IN THE NURSES’ HEALTH STUDY
Liao X, Spiegelman D, Hart J, Hong B, Puett R, Suh H, Laden F. AN APPLICATION OF A RISK SET CALIBRATION METHOD TO A STUDY OF AIR POLLUTION EFFECTS ON ALL CAUSE MORTALITY IN THE NURSES’ HEALTH STUDY. ISEE Conference Abstracts 2011, 2011 DOI: 10.1289/isee.2011.00990.Peer-Reviewed Original ResearchCause mortalityRelative riskHealth StudyChronic exposureChronic PM2.5 exposureNurses' Health StudyIndividual exposure levelsAverage of PM2.5Risk factorsExposure measurement errorState of residenceEstimates of riskParticipants' residencesPM2.5 exposureHealth outcomesMortalityMonthly exposureExposure levelsPersonal exposureExposure monitoringRiskCalendar yearAir pollution effectsExposureMidwestern metropolitan areaAnemia in TB patients predicts recurrence and mortality
Isanaka S, Mugusi F, Urassa W, Bosch R, Villamor E, Spiegelman D, Duggan C, Fawzi W. Anemia in TB patients predicts recurrence and mortality. The FASEB Journal 2011, 25: 779.14-779.14. DOI: 10.1096/fasebj.25.1_supplement.779.14.Peer-Reviewed Original ResearchTreatment failureIron deficiencyHypochromic microcytosisHIV-TB patientsCause of anemiaPoor clinical outcomeRisk of recurrenceMeasures of anemiaTuberculosis recurrenceHIV patientsTB patientsClinical outcomesSevere anemiaRisk factorsAnemiaOverall healthPatientsRecurrenceMortalityRiskMicrocytosisSignificant improvementAssociationDeficiencyFocused management
2004
Selenium Status Is Associated with Accelerated HIV Disease Progression among HIV-1–Infected Pregnant Women in Tanzania
Kupka R, Msamanga GI, Spiegelman D, Morris S, Mugusi F, Hunter DJ, Fawzi WW. Selenium Status Is Associated with Accelerated HIV Disease Progression among HIV-1–Infected Pregnant Women in Tanzania. Journal Of Nutrition 2004, 134: 2556-2560. PMID: 15465747, DOI: 10.1093/jn/134.10.2556.Peer-Reviewed Original ResearchConceptsPlasma selenium levelsCD4 cell countRisk of mortalityDisease progressionHIV-1-infected pregnant womenCell countSelenium levelsLow plasma selenium levelsHIV disease progressionAccelerated disease progressionCox multivariate modelSelenium statusMedian followHIV diseaseClinical outcomesPregnant womenPoor survivalTanzanian womenMultivariate modelL increaseCells/ProgressionWomenMortalityFirst yearAssociation Between Low Birth Weight and Infant Mortality in Children Born to Human Immunodeficiency Virus 1-Infected Mothers in Tanzania
Wei R, Msamanga GI, Spiegelman D, Hertzmark E, Baylin A, Manji K, Fawzi WW. Association Between Low Birth Weight and Infant Mortality in Children Born to Human Immunodeficiency Virus 1-Infected Mothers in Tanzania. The Pediatric Infectious Disease Journal 2004, 23: 530-535. PMID: 15194834, DOI: 10.1097/01.inf.0000129691.42964.eb.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCohort StudiesConfidence IntervalsDeveloping CountriesFemaleHIV InfectionsHIV-1HumansIncidenceInfant MortalityInfant, Low Birth WeightInfant, NewbornInfectious Disease Transmission, VerticalMalePregnancyPregnancy Complications, InfectiousPregnancy OutcomeProportional Hazards ModelsRisk FactorsSex DistributionSurvival AnalysisTanzaniaConceptsLow birth weightBirth weightHIV statusHIV transmissionInfant mortalityCox proportional hazards modelHuman immunodeficiency virus-1Child's HIV statusPediatric HIV infectionHuman immunodeficiency virusRisk of mortalityImmunodeficiency virus-1Proportional hazards modelWeeks of ageAntiretroviral treatmentHIV infectionImmunodeficiency virusNeonatal mortalityPositive infantsPregnant womenPostneonatal mortalityHazards modelMortalityInfantsVirus 1
2002
Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality
Fawzi WW, Msamanga GI, Hunter D, Renjifo B, Antelman G, Bang H, Manji K, Kapiga S, Mwakagile D, Essex M, Spiegelman D. Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. AIDS 2002, 16: 1935-1944. PMID: 12351954, DOI: 10.1097/00002030-200209270-00011.Peer-Reviewed Original ResearchConceptsHIV-1 transmissionInfants of mothersVitamin ALower baseline lymphocyte countsHigh erythrocyte sedimentation rateChild mortalityBaseline lymphocyte countMaternal micronutrient statusHIV-free survivalErythrocyte sedimentation rateLow birthweight babiesEarly child mortalityRisk of transmissionLymphocyte countLower hemoglobinMultivitamin supplementationWeeks' gestationBirthweight babiesPregnant womenHIV-1Vitamin supplementsMultivitaminsNutritional statusMicronutrient statusMortality
2001
Sex‐specific mortality from adult T‐cell leukemia among carriers of human T‐lymphotropic virus type I
Hisada M, Okayama A, Spiegelman D, Mueller N, Stuver S. Sex‐specific mortality from adult T‐cell leukemia among carriers of human T‐lymphotropic virus type I. International Journal Of Cancer 2001, 91: 497-499. PMID: 11251972, DOI: 10.1002/1097-0215(20010215)91:4<497::aid-ijc1044>3.0.co;2-a.Peer-Reviewed Original ResearchConceptsAdult T-cell leukemiaHTLV-I carriersHuman T-lymphotropic virus type IRelative riskVirus type IT-cell leukemiaIncidence of ATLMiyazaki Cohort StudyUnadjusted relative riskAdjusted relative riskType IPerinatal infectionEarlier average ageCohort studyMale predominanceRisk factorsAverage ageInfectionMortalityNumber of personsLeukemiaEarly ageMalesFemalesSex-specific mortality
2000
Adiposity and Mortality in Men
Baik I, Ascherio A, Rimm EB, Giovannucci E, Spiegelman D, Stampfer MJ, Willett WC. Adiposity and Mortality in Men. American Journal Of Epidemiology 2000, 152: 264-271. PMID: 10933273, DOI: 10.1093/aje/152.3.264.Peer-Reviewed Original ResearchConceptsBody mass indexRecent weight lossMeasures of adiposityCardiovascular diseaseGreater body mass indexWeight lossCardiovascular disease mortalityRisk of deathCancer mortality riskCause-specific mortalityExclusion of menLean menOverall mortalityWaist circumferenceMass indexDisease mortalityExcess mortalityRelative riskBody fatMortality riskUS menElevated riskOlder menHigh mortalityMortality
1997
A prospective study of malnutrition in relation to child mortality in the Sudan
Fawzi W, Herrera, Spiegelman D, Amin A, Nestel P, Mohamed K. A prospective study of malnutrition in relation to child mortality in the Sudan. American Journal Of Clinical Nutrition 1997, 65: 1062-1069. PMID: 9094894, DOI: 10.1093/ajcn/65.4.1062.Peer-Reviewed Original Research