2020
The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk
Spiegelman D, Lovato LC, Khudyakov P, Wilkens TL, Adebamowo CA, Adebamowo SN, Appel LJ, Beulens JW, Coughlin JW, Dragsted LO, Edenberg HJ, Eriksen JN, Estruch R, Grobbee DE, Gulayin PE, Irazola V, Krystal JH, Lazo M, Murray MM, Rimm EB, Schrieks IC, Williamson JD, Mukamal KJ. The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk. European Journal Of Preventive Cardiology 2020, 27: 1967-1982. PMID: 32250171, PMCID: PMC7541556, DOI: 10.1177/2047487320912376.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionCardiovascular Health TrialAlcohol consumptionHealth trialsCardiovascular diseaseModerate alcoholNon-fatal ischemic strokeNon-fatal myocardial infarctionPrimary composite endpointCongestive heart failureCoronary heart diseaseModerate alcohol consumersAdults 50 yearsPublic health guidelinesAlcohol use disorderPreferred alcoholic beverageCardiometabolic effectsCardiometabolic riskCarotid revascularizationIschemic strokeSecondary outcomesComposite endpointHeart failurePrimary outcomeMyocardial infarction
1999
Fruit and Vegetable Intake in Relation to Risk of Ischemic Stroke
Joshipura KJ, Ascherio A, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Hennekens CH, Spiegelman D, Willett WC. Fruit and Vegetable Intake in Relation to Risk of Ischemic Stroke. JAMA 1999, 282: 1233-1239. PMID: 10517425, DOI: 10.1001/jama.282.13.1233.Peer-Reviewed Original ResearchConceptsIschemic strokeIschemic stroke riskVegetable intakeRelative riskStroke riskGreen leafy vegetablesCardiovascular diseaseHealth StudyLower ischemic stroke riskStandard cardiovascular risk factorsCardiovascular risk factorsNurses' Health StudyProspective cohort studyApparent protective effectDay of fruitsConsumption of fruitsCohort studyHighest quintileLowest quintileRisk factorsTotal strokeProtective effectMAIN OUTCOMELower riskHealth professionals