Paratransgenic manipulation of a tsetse microRNA alters the physiological homeostasis of the fly’s midgut environment
Yang L, Weiss BL, Williams AE, Aksoy E, de Silva Orfano A, Son JH, Wu Y, Vigneron A, Karakus M, Aksoy S. Paratransgenic manipulation of a tsetse microRNA alters the physiological homeostasis of the fly’s midgut environment. PLOS Pathogens 2021, 17: e1009475. PMID: 34107000, PMCID: PMC8216540, DOI: 10.1371/journal.ppat.1009475.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedGastrointestinal MicrobiomeGenes, InsectHomeostasisInsect VectorsIntestinesMicroRNAsTrypanosomaTrypanosomiasis, AfricanTsetse FliesConceptsGut lumenCurrent disease control methodsTsetse's PMMidgut environmentTsetse's abilityAbundant secretory proteinsPeritrophic matrixInfection outcomesTrypanosome infection prevalenceChemotherapeutic treatmentParatransgenic manipulationInfected peopleEtiological agentInfection prevalenceInfectionInfection establishmentParasitic African trypanosomesCardiaSignificant increaseNon-coding RNAsPhysiological homeostasisMolecular cascadesBlood digestionSmall non-coding RNAsParatransgenic tsetse