Heme-induced genes facilitate endosymbiont (Sodalis glossinidius) colonization of the tsetse fly (Glossina morsitans) midgut
Runyen-Janecky L, Scheutzow J, Farsin R, Cabo L, Wall K, Kuhn K, Amador R, D’Souza S, Vigneron A, Weiss B. Heme-induced genes facilitate endosymbiont (Sodalis glossinidius) colonization of the tsetse fly (Glossina morsitans) midgut. PLOS Neglected Tropical Diseases 2022, 16: e0010833. PMID: 36441823, PMCID: PMC9731421, DOI: 10.1371/journal.pntd.0010833.Peer-Reviewed Original ResearchConceptsTsetse midgutHeme environmentDNA-binding proteinsGene Ontology termsBlood mealTsetse fly midgutVertebrate bloodBacterial genesHost midgutOntology termsDisease-causing pathogensBiological functionsGene expressionMutant strainFucose transporterInsertion mutationsMetabolic processesHost competencyEnvironmental stressorsFly midgutMidgutGenesSodalisTsetse fliesHemeTsetse Flies (Glossinidae)
Benoit J, Attardo G, Weiss B. Tsetse Flies (Glossinidae). 2022, 837-851. DOI: 10.1016/b978-0-12-818731-9.00004-5.Peer-Reviewed Original ResearchTsetse fliesUnique reproductive biologyPathogenic African trypanosomesFly biologyReproductive biologyVertebrate bloodEcological distributionEvolutionary adaptationInsect pestsLow fecundityPopulation suppressionAfrican trypanosomesUnique biologyHost locationFliesProgeny developmentBiologyPhysiological aspectsMulti-targeted strategiesAfrican trypanosomiasisHuman healthPestsFecundityTrypanosomesHigh investment