2015
Distributions of heavy metals in maternal and cord blood and the association with infant birth weight in China.
Hu X, Zheng T, Cheng Y, Holford T, Lin S, Leaderer B, Qiu J, Bassig BA, Shi K, Zhang Y, Niu J, Zhu Y, Li Y, Guo H, Chen Q, Zhang J, Xu S, Jin Y. Distributions of heavy metals in maternal and cord blood and the association with infant birth weight in China. The Journal Of Reproductive Medicine 2015, 60: 21-9. PMID: 25745747, PMCID: PMC4961246.Peer-Reviewed Original ResearchConceptsInfant birth weightCord blood samplesBirth weightCord bloodBlood samplesChinese pregnant womenMother-infant pairsBirth outcomesSerum levelsPregnant womenPrenatal exposureSerum concentrationsChinese infantsMultiple linear regression analysisLarger sample sizeLinear regression analysisSignificant associationChinese womenPilot studyBloodRegression analysisNewbornsAssociationWomenHigh concentrations
2012
An environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity
Fu A, Leaderer BP, Gent JF, Leaderer D, Zhu Y. An environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity. Clinical & Experimental Allergy 2012, 42: 1575-1581. PMID: 22862293, PMCID: PMC3673701, DOI: 10.1111/j.1365-2222.2012.04055.x.Peer-Reviewed Original ResearchConceptsChildhood asthma severityAsthma severitySevere asthmaSignificant associationSevere childhood asthmaBeta-agonist treatmentBeta-2 adrenergic receptorsImportant environmental exposuresAsthma exacerbationsAsthma medicationsMild asthmaChildhood asthmaSurrogate biomarkerMethylation-specific PCRPotential joint effectsClinical relevanceAdrenergic receptorsAsthmaADRB2SeverityEnvironmental exposuresIndoor exposureChildrenAssociationBlood
1996
Acute Exposure to Low-Level Methyl Tertiary-Butyl Ether (MTBE): Human Reactions and Pharmacokinetic Response
Cain W, Leaderer B, Ginsberg G, Andrews L, Cometto-muñiz J, Gent J, Buck M, Berglund L, Mohsenin V, Monahan E, Kjaergaard S. Acute Exposure to Low-Level Methyl Tertiary-Butyl Ether (MTBE): Human Reactions and Pharmacokinetic Response. Inhalation Toxicology 1996, 8: 21-48. DOI: 10.3109/08958379609005425.Peer-Reviewed Original ResearchDouble-blind studyEnd of exposureNasal inflammationBlood levelsAcute exposureComputerized performance testsHealthy adultsPharmacokinetic responseEye irritationSymptomsPharmacokinetic studyMethyl tertiary butyl etherDifferential effectsObjective effectsObjective correlatesExposureSubjectsPMNTertiary butyl etherOne-halfSubjects' ratingsInflammationLevelsBloodBaseline