2024
Family history of psychiatric conditions and development of siblings of children with autism
Bellia G, Chang J, Liew Z, Vernetti A, Macari S, Powell K, Chawarska K. Family history of psychiatric conditions and development of siblings of children with autism. Autism Research 2024 PMID: 38896553, DOI: 10.1002/aur.3175.Peer-Reviewed Original ResearchSiblings of childrenNeuropsychiatric disordersFamilies of childrenFamily history of schizophreniaYounger siblings of childrenHistory of psychiatric conditionsHistory of schizophreniaYounger siblingsAssess autism symptomsNonverbal IQAutism symptomsBipolar disorderIntellectual disabilityPsychiatric conditionsSubclinical symptomsAdaptive skillsSocial affectAdaptive functioningAutismFamily historyParent interviewsFamily factorsMultiple regression analysisDevelopmental outcomesDisordersAutism Spectrum Disorder and Grandmother’s Race, Ethnicity, and Nativity
Chow T, Meng Q, O’Sharkey K, Liew Z, Ritz B. Autism Spectrum Disorder and Grandmother’s Race, Ethnicity, and Nativity. JAACAP Open 2024 DOI: 10.1016/j.jaacop.2024.04.008.Peer-Reviewed Original ResearchIntellectual disabilityForeign-bornForeign-born whitesUS-born WhitesForeign-born blacksUS-born blacksForeign-born APIsUS-bornAsian-Pacific IslandersAutism spectrum disorderCalifornia DepartmentNativesGrandmothersPacific IslandersOdds ratioGrandchildrenEthnicityOffspring autism spectrum disorderRaceSelf-reported raceBirth certificatesMother-child pairsStudy investigated associationsWhitePublic healthMaternal intake of paracetamol during pregnancy and biomarkers of male fecundity in young adult sons
Laursen T, Ramlau-Hansen C, Tøttenborg S, Liew Z, Toft G, Gaml-Sørensen A, Hougaard K, Bonde J, Ernst A. Maternal intake of paracetamol during pregnancy and biomarkers of male fecundity in young adult sons. Reproductive Toxicology 2024, 127: 108626. PMID: 38815769, DOI: 10.1016/j.reprotox.2024.108626.Peer-Reviewed Original ResearchIntake of paracetamolMaternal intakeHigher DNA fragmentation indexDanish National Birth CohortDNA fragmentation indexSemen characteristicsLong durationImpaired semen qualityConfidence intervalsImpaired semen characteristicsNational Birth CohortReproductive hormone levelsAssociated with biomarkersDuration of exposureYears of ageFetal programmingNo intakeImmotile spermatozoaSons of mothersFollow-upYoung adult menHormone levelsSemen qualityMale fecundityTrimester-specificMediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes
Rogne T, Gill D, Liew Z, Shi X, Stensrud V, Nilsen T, Burgess S. Mediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes. JAMA Network Open 2024, 7: e2351166. PMID: 38206626, PMCID: PMC10784860, DOI: 10.1001/jamanetworkopen.2023.51166.Peer-Reviewed Original ResearchMeSH KeywordsBirth WeightCholesterolCohort StudiesDiabetes Mellitus, Type 2Educational StatusFemaleGenome-Wide Association StudyHumansHyperemesis GravidarumInfant, NewbornLipoproteins, HDLMediation AnalysisMendelian Randomization AnalysisPre-EclampsiaPregnancyPregnancy OutcomePregnancy, EctopicPremature BirthConceptsCardiometabolic risk factorsBody mass indexOffspring birth weightEducational attainmentMendelian randomizationHigh-density lipoprotein cholesterol levelsSystolic blood pressureInverse variance-weighted methodModifiable cardiometabolic risk factorsPregnancy outcomesCohort studyLipoprotein cholesterol levelsMR-Egger regressionMass indexUnivariable MR analysisEffects of educational attainmentAssociated with increased risk of adverse pregnancy outcomesPublic health interventionsMaternal education levelLower educational attainmentRisk factorsRisk of adverse pregnancy outcomesGenome-wide association studiesAssociated with increased riskBirth weight
2023
Association Between Estimated Geocoded Residential Maternal Exposure to Lithium in Drinking Water and Risk for Autism Spectrum Disorder in Offspring in Denmark
Liew Z, Meng Q, Yan Q, Schullehner J, Hansen B, Kristiansen S, Voutchkova D, Olsen J, Ersbøll A, Ketzel M, Raaschou-Nielsen O, Ritz B. Association Between Estimated Geocoded Residential Maternal Exposure to Lithium in Drinking Water and Risk for Autism Spectrum Disorder in Offspring in Denmark. Obstetrical & Gynecological Survey 2023, 78: 713-715. DOI: 10.1097/ogx.0000000000001228.Peer-Reviewed Original ResearchA scoping review of multigenerational impacts of grandparental exposures on mental health in grandchildren
Xiao J, Jain A, Bellia G, Nyhan K, Liew Z. A scoping review of multigenerational impacts of grandparental exposures on mental health in grandchildren. Current Environmental Health Reports 2023, 10: 369-382. PMID: 38008881, DOI: 10.1007/s40572-023-00413-8.Peer-Reviewed Original ResearchMental healthGrandparental ageAdverse delivery outcomesPregnancy-related factorsUse of diethylstilbestrolNeurodevelopmental disordersCurrent epidemiological studiesAttention-deficit/hyperactivity disorderMental health outcomesMedication intakeDelivery outcomesEpidemiological studiesHealth StudyHealth outcomesPregnancyBiological markersLiterature searchRecent FindingsWeHyperactivity disorderOutcome phenotypesSocial environmental stressorsDisordersExposure assessmentOutcomesMultigenerational effectsReevaluating the Association Between Autism and Lithium Exposure During Pregnancy—Reply
Liew Z, Raaschou-Nielsen O, Ritz B. Reevaluating the Association Between Autism and Lithium Exposure During Pregnancy—Reply. JAMA Pediatrics 2023, 177: 1241-1242. PMID: 37782480, DOI: 10.1001/jamapediatrics.2023.3954.Peer-Reviewed Original ResearchMaternal medically diagnosed infection and antibiotic prescription during pregnancy and risk of childhood cancer: A population‐based cohort study in Taiwan, 2004 to 2015
Sirirungreung A, Lee P, Hu Y, Liew Z, Ritz B, Heck J. Maternal medically diagnosed infection and antibiotic prescription during pregnancy and risk of childhood cancer: A population‐based cohort study in Taiwan, 2004 to 2015. International Journal Of Cancer 2023, 154: 626-635. PMID: 37792464, PMCID: PMC10942658, DOI: 10.1002/ijc.34744.Peer-Reviewed Original ResearchConceptsPopulation-based cohort studyMaternal infectionAcute lymphoblastic leukemiaAntibiotic prescriptionsChildhood cancerCohort studyChildhood acute lymphoblastic leukemiaChild Health DatabaseRisk of hepatoblastomaProportional hazards modelMother-child pairsMedian followTaiwan MaternalCancer RegistryLymphoblastic leukemiaAntibiotic useNational HealthAntibiotic exposureElevated riskHigh riskHazards modelPregnancyChildhood leukemiaHealth databasesChildhood hepatoblastomaPrenatal Exposure to Toxic Air Contaminants and the Risk for Cerebral Palsy
Zhuo H, Ritz B, Liew Z. Prenatal Exposure to Toxic Air Contaminants and the Risk for Cerebral Palsy. ISEE Conference Abstracts 2023, 2023 DOI: 10.1289/isee.2023.op-046.Peer-Reviewed Original ResearchLithium in Drinking Water and Autism Spectrum Disorder
Liew Z, Meng Q, Yan Q, Schullehner J, Hansen B, Kristiansen S, Voutchkova D, Olsen J, Ersbøll A, Ketzel M, Nielsen O, Ritz B. Lithium in Drinking Water and Autism Spectrum Disorder. ISEE Conference Abstracts 2023, 2023 DOI: 10.1289/isee.2023.op-075.Peer-Reviewed Original ResearchPer- and polyfluoroalkyl substances and sleep health in U.S. adults, NHANES 2005–2014
Guo P, Jin Z, Bellia G, Luo J, Inoue K, Pollitt K, Deziel N, Liew Z. Per- and polyfluoroalkyl substances and sleep health in U.S. adults, NHANES 2005–2014. Environmental Research 2023, 237: 117092. PMID: 37683785, DOI: 10.1016/j.envres.2023.117092.Peer-Reviewed Original ResearchSleep disordersSleep outcomesU.S. adultsNHANES 2005Inverse associationSleep durationSerum polyfluoroalkyl substancesCentral nervous systemSerum concentration dataDaily sleep durationExposure tertilesOxidative inflammatory responseQuartile increaseBias analysisInflammatory responseExcessive sleepUncontrolled confoundingNervous systemSleep healthPFAS exposureHealth measuresQuantitative bias analysisLogistic regressionConsistent associationDisordersSeason of Conception and Risk of Cerebral Palsy
Zhuo H, Ritz B, Warren J, Liew Z. Season of Conception and Risk of Cerebral Palsy. JAMA Network Open 2023, 6: e2335164. PMID: 37738049, PMCID: PMC10517373, DOI: 10.1001/jamanetworkopen.2023.35164.Peer-Reviewed Original ResearchConceptsCerebral palsySeason of conceptionCalifornia birth recordsCohort studyPreterm birthRelative riskBirth recordsRisk of CPStatewide cohort studyEtiological risk factorsHigher Social Vulnerability IndexLength of gestationDiagnostic recordsNeighborhood-level factorsSummer conceptionsRisk factorsStratified analysisLive birthsMAIN OUTCOMEHigh riskCP riskPoisson regressionCP statusDevelopmental servicesNeuromotor disabilitiesAntithyroid drug exposure during 1,191,904 pregnancies in denmark: a 20-year longitudinal study before and after implementation of iodine fortification
Maria U, Liew Z, Carle A, Scott K, Bulow P, Andersen S, Linding A. Antithyroid drug exposure during 1,191,904 pregnancies in denmark: a 20-year longitudinal study before and after implementation of iodine fortification. Endocrine Abstracts 2023 DOI: 10.1530/endoabs.92.op-06-01.Peer-Reviewed Original ResearchExposure to per- and polyfluoroalkyl substances in early pregnancy and risk of cerebral palsy in children
Vilhelmsson A, Rylander L, Jöud A, Lindh C, Mattsson K, Liew Z, Guo P, Ritz B, Källén K, Thacher J. Exposure to per- and polyfluoroalkyl substances in early pregnancy and risk of cerebral palsy in children. The Science Of The Total Environment 2023, 899: 165622. PMID: 37474063, DOI: 10.1016/j.scitotenv.2023.165622.Peer-Reviewed Original ResearchConceptsOdds ratioPreterm infantsEarly pregnancyPerfluorononanoic acidPrenatal PFAS exposureMaternal serum concentrationsCerebral palsy casesConfidence intervalsCase-control studyRisk of CPEnvironmental risk factorsPositive associationContinuous variablesHigh PFASPalsy casesBirth RegistryPreterm controlsCerebral palsyLifestyle factorsPreterm casesUnexplained etiologyPrenatal exposureSerum concentrationsRisk factorsPerfluorooctane sulfonateHyperthyroidism in Danish Pregnant Women During a 20-Year Period
Torp N, Liew Z, Carlé A, Karmisholt J, Pedersen I, Andersen S, Andersen S. Hyperthyroidism in Danish Pregnant Women During a 20-Year Period. The Journal Of Clinical Endocrinology & Metabolism 2023, 109: e370-e378. PMID: 37437100, DOI: 10.1210/clinem/dgad410.Peer-Reviewed Original ResearchConceptsDanish pregnant womenOccurrence of hyperthyroidismAntithyroid drugsPregnant womenBiochemical hyperthyroidismMandatory iodine fortification programmeNationwide register-based cohortUse of ATDsRegister-based cohortIodine fortification programGeneral Danish populationNationwide cohortAutoimmune hyperthyroidismMaternal useOdds ratioTime-related differencesHyperthyroidismBirth cohortClinical concernBaseline levelsDanish populationFortification programsPregnancyCohortYoung individualsOffspring neurodevelopmental outcomes born to parents with chronic inflammatory arthritis using antirheumatic therapies: A scoping review
Chock E, Dahal S, Grimshaw A, Suter L, Liew Z, Felson D. Offspring neurodevelopmental outcomes born to parents with chronic inflammatory arthritis using antirheumatic therapies: A scoping review. Seminars In Arthritis And Rheumatism 2023, 61: 152230. PMID: 37295300, PMCID: PMC10521166, DOI: 10.1016/j.semarthrit.2023.152230.Peer-Reviewed Original ResearchConceptsChronic inflammatory arthritisOffspring neurodevelopmental outcomesAntirheumatic therapyNeurodevelopmental outcomesInflammatory arthritisTumor necrosis factor-alpha inhibitorsNecrosis factor-alpha inhibitorsNonsteroidal anti-inflammatory drugsEarly first trimesterOffspring health outcomesAnti-inflammatory drugsMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsWeb of ScienceAttention deficit hyperactive disorderCorticosteroid useRheumatic diseasesFirst trimesterCochrane LibraryAlpha inhibitorsStudy qualityMedication safetyFetal wellbeingIndependent reviewersMost womenAssociation Between Estimated Geocoded Residential Maternal Exposure to Lithium in Drinking Water and Risk for Autism Spectrum Disorder in Offspring in Denmark
Liew Z, Meng Q, Yan Q, Schullehner J, Hansen B, Kristiansen S, Voutchkova D, Olsen J, Ersbøll A, Ketzel M, Raaschou-Nielsen O, Ritz B. Association Between Estimated Geocoded Residential Maternal Exposure to Lithium in Drinking Water and Risk for Autism Spectrum Disorder in Offspring in Denmark. JAMA Pediatrics 2023, 177: 617-624. PMID: 37010840, PMCID: PMC10071398, DOI: 10.1001/jamapediatrics.2023.0346.Peer-Reviewed Original ResearchConceptsMaternal exposureOdds ratioStratified analysisNationwide population-based case-control studyPopulation-based case-control studyDanish Medical Birth RegistryDanish Psychiatric Central RegisterAutism spectrum disorderMedical Birth RegistryNovel environmental risk factorTenth Revision codesAdverse birth outcomesControl participantsMaternal prenatal exposureMaternal residential addressBirth yearCase-control studyPsychiatric Central RegisterMood-stabilizing effectsAir pollution exposureEnvironmental risk factorsInternational Statistical ClassificationWnt/β-catenin signalingStudy teamRelated Health ProblemsResidential proximity to unconventional oil and gas development and birth defects in Ohio
Gaughan C, Sorrentino K, Liew Z, Johnson N, Clark C, Soriano M, Plano J, Plata D, Saiers J, Deziel N. Residential proximity to unconventional oil and gas development and birth defects in Ohio. Environmental Research 2023, 229: 115937. PMID: 37076028, PMCID: PMC10198955, DOI: 10.1016/j.envres.2023.115937.Peer-Reviewed Original ResearchConceptsNeural tube defectsCertain birth defectsBirth defectsOdds ratioRegistry-based cohort studyTube defectsConfidence intervalsResidential proximityState birth recordsBirth defect typeState surveillance systemsMaternal residential proximityLimb reduction defectsCohort studyUnexposed mothersStructural birth defectsLive birthsInfant sexBirth recordsSpina bifidaReduction defectsFemale offspringDevelopmental toxicantsExposure metricsCerebral Palsy and Maternal Injury During Pregnancy
Liew Z, Zhuo H. Cerebral Palsy and Maternal Injury During Pregnancy. JAMA Pediatrics 2023, 177: 10-11. PMID: 36441524, DOI: 10.1001/jamapediatrics.2022.4541.Peer-Reviewed Original Research
2022
Parental Age and Childhood Risk for Cerebral Palsy in California
Zhou L, Meng Q, von Ehrenstein O, Xiao J, Gao Y, Wu Y, Ritz B, Liew Z. Parental Age and Childhood Risk for Cerebral Palsy in California. The Journal Of Pediatrics 2022, 255: 147-153.e6. PMID: 36372095, PMCID: PMC10121738, DOI: 10.1016/j.jpeds.2022.10.039.Peer-Reviewed Original ResearchConceptsCerebral palsyPaternal ageGreater riskPreterm birthMaternal ageParental ageRisk of CPYoung maternal ageBirth certificate recordsCase-control studyTime of deliveryChildren of mothersOlder paternal ageCP diagnosisPreterm deliveryOffspring riskCertificate recordsCP casesCP riskSingleton controlsAge 20Older mothersAge 25Older ageChildhood risk