2016
Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of IL-1 β and protein expression in spinal cord of mice
Piccinelli A, Morato P, dos Santos Barbosa M, Croda J, Sampson J, Kong X, Konkiewitz E, Ziff E, Amaya-Farfan J, Kassuya C. Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of IL-1 β and protein expression in spinal cord of mice. Life Sciences 2016, 174: 28-34. PMID: 27888114, DOI: 10.1016/j.lfs.2016.11.017.Peer-Reviewed Original ResearchConceptsIL-1βSpinal cordMechanical hyperalgesiaIntrathecal injectionIL-10Electronic von Frey apparatusAbility of gp120SOD expressionAnti-inflammatory actionIL-1β injectionMale Swiss miceIL-1 βIL-1β applicationGp120 administrationGp120 injectionAntihyperalgesic effectIntrathecal administrationMechanical sensitivityPrior administrationCytokine productionSwiss miceBlood samplesSterile salineHyperalgesiaPeripheral increase
2008
Targeted Mutagenesis in Pathogenic Leptospira Species: Disruption of the LigB Gene Does Not Affect Virulence in Animal Models of Leptospirosis▿
Croda J, Figueira CP, Wunder EA, Santos CS, Reis MG, Ko AI, Picardeau M. Targeted Mutagenesis in Pathogenic Leptospira Species: Disruption of the LigB Gene Does Not Affect Virulence in Animal Models of Leptospirosis▿. Infection And Immunity 2008, 76: 5826-5833. PMID: 18809657, PMCID: PMC2583567, DOI: 10.1128/iai.00989-08.Peer-Reviewed Original ResearchConceptsPathogenic Leptospira speciesLeptospira speciesAcute disease manifestationsPersistent renal colonizationInoculation of ratsDisease manifestationsHamster modelRenal colonizationPathogenic mechanismsAnimal modelsPersistent colonizationDecrease virulenceLeptospira interrogansHomologous recombinationLeptospirosisVirulence factorsBacterial adherenceImmunoblot analysisCorresponding chromosomal locusWild-type strainCultured cellsFirst evidenceSpectinomycin resistance geneRepeat proteinsTargeted Mutagenesis