2019
Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility
Huang H, Kuang H, Sun F, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson PR, Christman GM, Hansen KR, Santoro N, Eisenberg E, Zhang H, Network E. Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility. Fertility And Sterility 2019, 111: 1011-1019.e1. PMID: 30926125, PMCID: PMC6487215, DOI: 10.1016/j.fertnstert.2019.01.020.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeUnexplained infertilityUterine fibroidsLow prevalenceOvary syndromeDifferent body mass index (BMI) groupsBody mass index groupsHigher body mass indexHigher total testosteroneNormal uterine cavityAssessment-insulin resistanceBody mass indexRandomized clinical trialsCurrent alcohol usersPrevalence of womenTotal testosteroneCurrent smokersInfertile womenLarge fibroidsMass indexInfertile patientsInsulin resistanceUterine cavityClinical trialsLower percentage
2015
Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility
Diamond M, Legro R, Coutifaris C, Alvero R, Robinson R, Casson P, Christman G, Ager J, Huang H, Hansen K, Baker V, Usadi R, Seungdamrong A, Bates G, Rosen R, Haisenleder D, Krawetz S, Barnhart K, Trussell J, Ohl D, Jin Y, Santoro N, Eisenberg E, Zhang H. Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. Obstetrical & Gynecological Survey 2015, 70: 757-758. DOI: 10.1097/ogx.0000000000000275.Peer-Reviewed Original ResearchOvarian stimulationUnexplained infertilityMultiple gestationsLetrozole groupCongenital anomaliesPregnancy rateLive birthsNormal uterine cavityStandard therapy groupUse of clomipheneOvarian hyperstimulation syndromeFirst-line therapyLive birth ratePatent fallopian tubesPolycystic ovary syndromeMultiple gestation ratesCause of infertilityPlacebo control groupNormal sperm countYears of ageImproved pregnancy ratesFetal heart activityHyperstimulation syndromeMonofollicular developmentNeonatal complications
2014
Letrozole Versus Clomiphene for Infertility in the Polycystic Ovary Syndrome
Legro R, Brzyski R, Diamond M, Coutifaris C, Schlaff W, Casson P, Christman G, Huang H, Yan Q, Alvero R, Haisenleder D, Barnhart K, Bates G, Usadi R, Lucidi S, Baker V, Trussell J, Krawetz S, Snyder P, Ohl D, Santoro N, Eisenberg E, Zhang H. Letrozole Versus Clomiphene for Infertility in the Polycystic Ovary Syndrome. Obstetrical & Gynecological Survey 2014, 69: 599-601. DOI: 10.1097/01.ogx.0000456355.64379.77.Peer-Reviewed Original ResearchPolycystic ovary syndromeAdverse effect profileMultiple pregnancy rateEffect profileFertility agentsAromatase inhibitorsLive birthsHigher multiple pregnancy rateLower multiple pregnancy rateSelective estrogen receptor modulatorsMale partnersNormal uterine cavityPatent fallopian tubesPrimary study outcomeCumulative live birthReproductive-age womenGood safety profileEstrogen receptor modulatorsClomiphene groupLetrozole groupClomiphene citrateRotterdam criteriaHot flushesOvary syndromeInfertile women