2024
Demonstrating service delivery models for effective initiation and retention on pre-exposure prophylaxis (PrEP) among female bar workers in Dar es Salaam, Tanzania: A double randomized intervention study protocol
Chebet J, Akyoo W, Goymann H, Harling G, Barnhart D, Mosha I, Kamori D, Gandhi M, Mbunda T, Kipeleka J, Sando D, Spiegelman D, Mpembeni R, Bärnighausen T. Demonstrating service delivery models for effective initiation and retention on pre-exposure prophylaxis (PrEP) among female bar workers in Dar es Salaam, Tanzania: A double randomized intervention study protocol. PLOS ONE 2024, 19: e0304077. PMID: 38935796, PMCID: PMC11210872, DOI: 10.1371/journal.pone.0304077.Peer-Reviewed Original ResearchConceptsFemale bar workersPre-exposure prophylaxisIntention-to-treatBar workersPrimary outcomeRisk of HIV infectionAdherence to PrEPRisk of HIV acquisitionImprove PrEP adherenceGerman Clinical Trials RegisterPublic sector clinicsService delivery modelsRandomized trial designHIV negative womenPrevent HIV infectionHIV infectionPrEP provisionClinical Trials RegisterHIV testingPrEP initiationHealth facilitiesPromote PrEPPrEP adherenceDelivery modelsReduce barriersNavigating grey areas in HIV and mental health implementation science
Harkness A, Giusto A, Hamilton A, Hernandez‐Ramirez R, Spiegelman D, Weiner B, Beidas R, Larson M, Lippman S, Wainberg M, Smith J. Navigating grey areas in HIV and mental health implementation science. Journal Of The International AIDS Society 2024, 27: e26271. PMID: 38923301, PMCID: PMC11197965, DOI: 10.1002/jia2.26271.Peer-Reviewed Original ResearchConceptsImplementation scienceNational Institute of Mental HealthImplementation researchMental healthImplementation strategiesImpact of implementation strategiesHIV Epidemic goalsInstitute of Mental HealthUNAIDS targetsFederal fundersResearch workforceHIV transmissionEvidence-basedGlobal HIVUnited StatesHIVCapacity buildingRecipient's perspectiveNational InstituteHealthExpert guidanceInterventionHigh-impact scienceControl groupOvercome challengesAssessing Direct and Spillover Effects of Intervention Packages in Network-randomized Studies
Buchanan A, Hernández-Ramírez R, Lok J, Vermund S, Friedman S, Forastiere L, Spiegelman D. Assessing Direct and Spillover Effects of Intervention Packages in Network-randomized Studies. Epidemiology 2024, 35: 481-488. PMID: 38709023, DOI: 10.1097/ede.0000000000001742.Peer-Reviewed Original ResearchIntervention packageEffectiveness of interventional packageImprove intervention deliveryPeer education interventionHIV prevention trialsPeer educator trainingMarginal structural modelsPublic health impactHIV risk behaviorsIntervention deliveryIntervention NetworkEducational interventionParticipant visitsPrevention trialsFollow-up visitRisk behaviorsHealth impactsInterventionEducational trainingParticipantsSpillover effectsVisitsHIVExposed networksPeerEffects of a dietary intervention on cardiometabolic risk and food consumption in a workplace
Shrestha A, Tamrakar D, Ghinanju B, Shrestha D, Khadka P, Adhikari B, Shrestha J, Waiwa S, Pyakurel P, Bhandari N, Karmacharya B, Shrestha A, Shrestha R, Bhatta R, Malik V, Mattei J, Spiegelman D. Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace. PLOS ONE 2024, 19: e0301826. PMID: 38656951, PMCID: PMC11042715, DOI: 10.1371/journal.pone.0301826.Peer-Reviewed Original ResearchConceptsConsumption of whole grainsHealthy foodPre-post intervention studyWhole grainsMedian consumptionCardiovascular risk factor profileRisk factor profileBlood pressureWorksite settingWorksite interventionsUnhealthy foodsHealth programsMeasured blood pressurePre-hypertensionCardiometabolic riskDiastolic blood pressureIntervention studiesFactors dietPaired-t testFactor profileFasting glucose levelsDhulikhel HospitalHospital premisesEmployee healthHospital employeesBarriers and Facilitators of Implementing a Healthy Lifestyle Intervention at Workplaces in South Africa
Singh S, Naicker A, Grobbelaar H, Singh E, Spiegelman D, Shrestha A. Barriers and Facilitators of Implementing a Healthy Lifestyle Intervention at Workplaces in South Africa. International Journal Of Environmental Research And Public Health 2024, 21: 389. PMID: 38673303, PMCID: PMC11050208, DOI: 10.3390/ijerph21040389.Peer-Reviewed Original ResearchFocus group discussionsHealthy lifestyle interventionIn-depth interviewsLifestyle interventionIntervention programmeDesigning lifestyle interventionsImplement lifestyle interventionsCardiovascular risk factor profileLifestyle intervention programmeImprove health outcomesImplementing health programmesLack of willpowerSemi-structured in-depth interviewsRisk factor profileImplementing intervention programmesFood environmentHealth outcomesImplement interventionsHealth programmesWorkplace stakeholdersWellness programmesWorkplace supportLifestyle choicesFactor profileGroup discussionsImproving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial
Puklin L, Ferrucci L, Harrigan M, McGowan C, Zupa M, Cartmel B, Li F, Ligibel J, Spiegelman D, Sharifi M, Sanft T, Irwin M. Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial. Cancer 2024, 130: 2440-2452. PMID: 38470431, PMCID: PMC11214600, DOI: 10.1002/cncr.35280.Peer-Reviewed Original ResearchPhysical activityDiet qualityHEI-2015Strength trainingLifestyle behaviorsHealthy Eating Index (HEI)-2015Breast cancerAssociated with baseline fatigueImprove physical activityImprove lifestyle behaviorsHigher HEI-2015Associated with higher oddsExercise interventionUsual careIntervention armIntervention groupBaseline fatigueLifestyle interventionYearlong interventionLower fatigueHigher oddsSecondary analysisLogistic regressionNewly diagnosed patientsStudy armsCausal Selection of Covariates in Regression Calibration for Mismeasured Continuous Exposure
Tang W, Spiegelman D, Liao X, Wang M. Causal Selection of Covariates in Regression Calibration for Mismeasured Continuous Exposure. Epidemiology 2024, 35: 320-328. PMID: 38630507, DOI: 10.1097/ede.0000000000001706.Peer-Reviewed Original ResearchConceptsMismeasured exposureOutcome modelRegression calibrationMeasurement error modelSelection of covariatesNonparametric settingEffect modificationCovariate adjustmentFiber intakeMeasurement errorCardiovascular diseaseEffects of fiber intakeStudy datasetOutcomesCovariatesComprehensive guidanceError modelRegressionHealthEfficiency lossErrorRosnerWillettExposureAdjustment
2023
Post-diagnosis weight trajectories and mortality among women with breast cancer
Puklin L, Li F, Cartmel B, Zhao J, Sanft T, Lisevick A, Winer E, Lustberg M, Spiegelman D, Sharifi M, Irwin M, Ferrucci L. Post-diagnosis weight trajectories and mortality among women with breast cancer. Npj Breast Cancer 2023, 9: 98. PMID: 38042922, PMCID: PMC10693588, DOI: 10.1038/s41523-023-00603-5.Peer-Reviewed Original ResearchBody mass indexBreast cancer diagnosisWeight changeCause mortalityClinical characteristicsWeight gainWeight lossBreast cancerWeight trajectoriesPost-diagnosis weight changeBreast cancer-specific mortalityCox proportional hazards modelModern treatment eraCancer-specific mortalityCancer diagnosisModerate weight lossModerate weight gainProportional hazards modelAdverse health outcomesElectronic health recordsTreatment eraBaseline characteristicsTumor RegistryMass indexWeight managementOverall, Direct, Spillover, and Composite Effects of Components of a Peer-Driven Intervention Package on Injection Risk Behavior Among People Who Inject Drugs in the HPTN 037 Study
Hernández-Ramírez R, Spiegelman D, Lok J, Forastiere L, Friedman S, Latkin C, Vermund S, Buchanan A. Overall, Direct, Spillover, and Composite Effects of Components of a Peer-Driven Intervention Package on Injection Risk Behavior Among People Who Inject Drugs in the HPTN 037 Study. AIDS And Behavior 2023, 28: 225-237. PMID: 37932493, PMCID: PMC11062514, DOI: 10.1007/s10461-023-04213-x.Peer-Reviewed Original ResearchInjection risk behaviorsPeer education interventionRisk behaviorsClinical trial registrationSubsequent risk behaviorsTRIAL REGISTRATIONOutcome ratesSecondary data analysisIndex individualsRoutine evaluationIntervention componentsIntervention NetworkMixed effects modelsIntervention packageGroups/networksPeer education trainingPeer educatorsOverall rateInterventionPeer educationEffects modelTraining sessionsDrugsControl conditionBehavioral measuresReasons for using traditional and complementary care by people living with HIV on antiretroviral therapy and association with interrupted care: a mixed methods study in Eswatini
Molemans M, Reis R, Shabalala F, Dlamini N, Masilela N, Simelane N, Pell C, Chao A, Spiegelman D, Vernooij E, van Leth F. Reasons for using traditional and complementary care by people living with HIV on antiretroviral therapy and association with interrupted care: a mixed methods study in Eswatini. BMC Complementary Medicine And Therapies 2023, 23: 350. PMID: 37794359, PMCID: PMC10548651, DOI: 10.1186/s12906-023-04184-5.Peer-Reviewed Original ResearchConceptsInterrupted careAntiretroviral therapyType of illnessCurrent usersTCAM providersTCAM usersHIV diagnosisHIV continuumClinic recordsMultivariable analysisComplementary careVisit dateHealth facilitiesAlternative medicineTCAM useBiomedical careCareAdditional careMixed-methods studyHIVTherapyQualitative content analysisOpen-ended questionsMethods studyContextual factorsRandomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors
Puklin L, Harrigan M, Cartmel B, Sanft T, Gottlieb L, Zhou B, Ferrucci L, Li F, Spiegelman D, Sharifi M, Irwin M. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers 2023, 15: 4719. PMID: 37835412, PMCID: PMC10571774, DOI: 10.3390/cancers15194719.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsLifestyle interventionPhysical activityQuality of lifeBody weightWaitlist groupDiet qualitySelf-reported body weightWeight lossFavorable weight changeHealthy weight lossBody mass indexHealthy body weightGreater weight lossEvidence-based materialsDiverse healthcare settingsIntervention armMass indexClinical practicePositive behavior changeHealthcare settingsSurvivorsWeight changeInterventionTrusted residents and housing assistance to decrease violence exposure in New Haven (TRUE HAVEN): a strengths-based and community-driven stepped-wedge intervention to reduce gun violence
Tong G, Spell V, Horton N, Thornhill T, Keene D, Montgomery C, Spiegelman D, Wang E, Roy B. Trusted residents and housing assistance to decrease violence exposure in New Haven (TRUE HAVEN): a strengths-based and community-driven stepped-wedge intervention to reduce gun violence. BMC Public Health 2023, 23: 1545. PMID: 37580653, PMCID: PMC10426138, DOI: 10.1186/s12889-023-15997-x.Peer-Reviewed Original ResearchConceptsGun violenceHousing assistanceStructural racismHousing stabilityViolence exposureMulti-level interventionsCommunity gun violenceMulti-stakeholder coalitionsRental assistance programsCommunity-based organizationsHousing supportPolicy changesFinancial educationStable housingBeing of individualsViolenceTarget neighborhoodsCommunity membersNew HavenNeighborhood ratesAssistance programsOrganization leadersRacismHavenNeighborhoodFactors associated with receiving results and attending colposcopy in patients with positive HPV screens in Mexico City
León-Maldonado L, Hernández-Ramírez R, Torres-Ibarra L, Spiegelman D, Sheth S, Lazcano E, Cadena-Fiscal J, Salmerón J. Factors associated with receiving results and attending colposcopy in patients with positive HPV screens in Mexico City. Preventive Medicine Reports 2023, 35: 102347. PMID: 37593354, PMCID: PMC10428024, DOI: 10.1016/j.pmedr.2023.102347.Peer-Reviewed Original ResearchPercent of participantsColposcopy appointmentHealthcare facilitiesHigh-risk human papillomavirusMultivariable logistic regressionHealthcare system factorsScreening resultsPositive screening resultsColposcopy adherenceColposcopy clinicHPV screenPrevious PapMedian ageCervical cancerPap testHuman papillomavirusHigh school educationPatientsGreater adherenceExperienced nursesGood complianceLogistic regressionScheduling appointmentsLimited staff availabilityAdherenceEstimation and inference for exposure effects with latency in the Cox proportional hazards model in the presence of exposure measurement error
Peskoe S, Zhang N, Spiegelman D, Wang M. Estimation and inference for exposure effects with latency in the Cox proportional hazards model in the presence of exposure measurement error. The Annals Of Applied Statistics 2023, 17 DOI: 10.1214/22-aoas1682.Peer-Reviewed Original ResearchCorrecting for Bias Due to Mismeasured Exposure History in Longitudinal Studies with Continuous Outcomes
Cai J, Zhang N, Zhou X, Spiegelman D, Wang M. Correcting for Bias Due to Mismeasured Exposure History in Longitudinal Studies with Continuous Outcomes. Biometrics 2023, 79: 3739-3751. PMID: 37222518, PMCID: PMC11214728, DOI: 10.1111/biom.13877.Peer-Reviewed Original ResearchAssociation between cancer stigma and cervical cancer screening uptake among women of Dhulikhel and Banepa, Nepal
Paneru B, Karmacharya A, Bharati A, Makaju S, Adhikari B, Kafle D, Shakya S, Spiegelman D, Seth S, Stangl A, Shrestha A, Shrestha A. Association between cancer stigma and cervical cancer screening uptake among women of Dhulikhel and Banepa, Nepal. PLOS ONE 2023, 18: e0285771. PMID: 37200234, PMCID: PMC10194964, DOI: 10.1371/journal.pone.0285771.Peer-Reviewed Original ResearchConceptsCervical cancer screening uptakeCancer screening uptakeScreening uptakeMultivariable logistic regressionCancer Stigma ScaleCancer stigmaCervical cancerAge of menarcheFirst sexual intercourseLogistic regressionNepalese womenSexual intercourseReproductive health variablesCervical cancer screeningEffective screening programsSemi-urban areasCross-sectional studyPercent of womenMean total scoreFamily planning usersScreening servicesCancer screeningCommon cancerDisease burdenScreening programMediation analysis in the presence of continuous exposure measurement error
Cheng C, Spiegelman D, Li F. Mediation analysis in the presence of continuous exposure measurement error. Statistics In Medicine 2023, 42: 1669-1686. PMID: 36869626, DOI: 10.1002/sim.9693.Peer-Reviewed Original ResearchConceptsBody mass indexExposure measurement errorPhysical activityMediation proportionHealth Professionals FollowCardiovascular disease incidenceProfessionals FollowMediation analysisMass indexCardiovascular diseaseLower riskStudy designEffect estimatesValidation study designContinuous exposureBiased effect estimatesTrue exposureMediatorsExposureValidation studyBinary outcomesHealth science studiesOutcomesRiskDisease incidenceValidation of the Cancer Stigma Scale in Nepalese Women
Shrestha A, Stangl A, Paneru B, Poudel L, Karmacharya A, Makaju S, Spiegelman D, Shakya S, Shrestha A, Sheth S. Validation of the Cancer Stigma Scale in Nepalese Women. Asian Pacific Journal Of Cancer Prevention 2023, 24: 204-214. PMID: 36708569, PMCID: PMC10152840, DOI: 10.31557/apjcp.2023.24.1.207.Peer-Reviewed Original ResearchConceptsCancer Stigma ScaleCancer stigmaCancer patientsStigma ScaleCronbach's alphaNepali womenInternal consistencyCross-cultural adaptationNepalese populationNepalese womenSufficient internal consistencyCancerWomenPatientsSatisfactory internal reliabilityVulnerable groupsAlphaInternal reliabilityStigmaOverall scaleModel fit indicesHigh levelsSix-factor structure
2022
Design and Implementation of a Culturally-Tailored Randomized Pilot Trial: Puerto Rican Optimized Mediterranean-Like Diet
Mattei J, Díaz-Alvarez C, Alfonso C, O’Neill H, Ríos-Bedoya C, Malik V, Godoy-Vitorino F, Cheng C, Spiegelman D, Willett W, Hu F, Rodríguez-Orengo J. Design and Implementation of a Culturally-Tailored Randomized Pilot Trial: Puerto Rican Optimized Mediterranean-Like Diet. Current Developments In Nutrition 2022, 7: 100022. PMID: 37181130, PMCID: PMC10100940, DOI: 10.1016/j.cdnut.2022.100022.Peer-Reviewed Original ResearchMediterranean-like dietNutritional counseling sessionsPilot trialHealthier cardiometabolic profileIndividual cardiometabolic factorsCardiometabolic risk factorsRandomized pilot trialDisease prevention programsCounseling sessionsDaily text messagesFree-living adultsCardiometabolic factorsCardiometabolic profileCardiometabolic healthSecondary outcomesPrimary outcomeRisk factorsDietary intakeIntervention groupChronic diseasesTwo-armOutcome measuresHigh riskMediterranean dietPsychosocial factorsEffectiveness of a community-based education and peer support led by women’s self-help groups in improving the control of hypertension in urban slums of Kerala, India: a cluster randomised controlled pragmatic trial
Suseela R, Ambika R, Mohandas S, Menon J, Numpelil M, Vasudevan B, Ved R, Danaei G, Spiegelman D. Effectiveness of a community-based education and peer support led by women’s self-help groups in improving the control of hypertension in urban slums of Kerala, India: a cluster randomised controlled pragmatic trial. BMJ Global Health 2022, 7: e010296. PMID: 36384950, PMCID: PMC9670931, DOI: 10.1136/bmjgh-2022-010296.Peer-Reviewed Original ResearchConceptsMean systolic BPSystolic BPControl armIntervention armPragmatic trialUrban slumsTarget blood pressure goalsMajor public health problemBlood pressure goalsSelf-help group membersControl of hypertensionStandard of carePublic health problemPrimary healthcare systemSelf-help groupsCommunity-based educationPeer support programAntihypertensive medicationsUncontrolled hypertensionUsual careHypertension managementPrimary outcomeHypertensionHealthy behaviorsHealth problems