2009
Intakes of Fruit, Vegetables, and Carotenoids and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies
Lee JE, Männistö S, Spiegelman D, Hunter DJ, Bernstein L, van den Brandt PA, Buring JE, Cho E, English DR, Flood A, Freudenheim JL, Giles GG, Giovannucci E, Håkansson N, Horn-Ross PL, Jacobs EJ, Leitzmann MF, Marshall JR, McCullough ML, Miller AB, Rohan TE, Ross JA, Schatzkin A, Schouten LJ, Virtamo J, Wolk A, Zhang SM, Smith-Warner SA. Intakes of Fruit, Vegetables, and Carotenoids and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies. Cancer Epidemiology Biomarkers & Prevention 2009, 18: 1730-1739. PMID: 19505906, PMCID: PMC2883186, DOI: 10.1158/1055-9965.epi-09-0045.Peer-Reviewed Original ResearchConceptsPooled multivariate relative risksRenal cell cancerMultivariate relative riskCell cancerRelative riskVegetable consumptionProspective studyPooled analysisStudy-specific relative risksRenal cell cancer riskCox proportional hazards modelFood frequency questionnaireIntake of fruitsLutein/zeaxanthinProportional hazards modelRandom-effects modelTotal vegetablesIncident casesLowest quintileVegetable intakeCancer riskHazards modelCancerTotal fruitRisk
2005
Fruits and Vegetables and Ovarian Cancer Risk in a Pooled Analysis of 12 Cohort Studies
Koushik A, Hunter DJ, Spiegelman D, Anderson KE, Arslan AA, Beeson WL, van den Brandt PA, Buring JE, Cerhan JR, Colditz GA, Fraser GE, Freudenheim JL, Genkinger JM, Goldbohm RA, Hankinson SE, Koenig KL, Larsson SC, Leitzmann M, McCullough ML, Miller AB, Patel A, Rohan TE, Schatzkin A, Smit E, Willett WC, Wolk A, Zhang SM, Smith-Warner SA. Fruits and Vegetables and Ovarian Cancer Risk in a Pooled Analysis of 12 Cohort Studies. Cancer Epidemiology Biomarkers & Prevention 2005, 14: 2160-2167. PMID: 16172226, DOI: 10.1158/1055-9965.epi-05-0218.Peer-Reviewed Original ResearchConceptsOvarian cancer riskVegetable intakeOvarian cancerCancer riskRelative riskPooled multivariate relative risksStudy-specific relative risksInvasive epithelial ovarian cancerCox proportional hazards modelTotal fruit intakeMultivariate relative riskFood frequency questionnaireTotal vegetable intakeEpithelial ovarian cancerProportional hazards modelDifferent histologic typesRandom-effects modelCancer-preventive actionsCohort studyHistologic typeProspective studyPooled analysisFruit intakeLowest quartileHazards modelDietary flavonols and flavonol‐rich foods intake and the risk of breast cancer
Adebamowo CA, Cho E, Sampson L, Katan MB, Spiegelman D, Willett WC, Holmes MD. Dietary flavonols and flavonol‐rich foods intake and the risk of breast cancer. International Journal Of Cancer 2005, 114: 628-633. PMID: 15609322, DOI: 10.1002/ijc.20741.Peer-Reviewed Original ResearchConceptsMultivariate relative riskBreast cancer riskCumulative average intakeFlavonol-rich foodsIntake of beansRelative riskBreast cancerCancer riskFlavonol intakeLowest quintileInverse associationDietary flavonolsAverage intakeNurses' Health Study IIIntake of flavonolsHealth Study IIFood frequency questionnaireInvasive breast cancerSignificant inverse associationFrequency questionnaireEpidemiological studiesAnimal studiesDietary dataOverall associationFurther evaluation
2004
Dietary Carotenoids and Risk of Lung Cancer in a Pooled Analysis of Seven Cohort Studies
Männistö S, Smith-Warner SA, Spiegelman D, Albanes D, Anderson K, van den Brandt PA, Cerhan JR, Colditz G, Feskanich D, Freudenheim JL, Giovannucci E, Goldbohm RA, Graham S, Miller AB, Rohan TE, Virtamo J, Willett WC, Hunter DJ. Dietary Carotenoids and Risk of Lung Cancer in a Pooled Analysis of Seven Cohort Studies. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 40-48. PMID: 14744731, DOI: 10.1158/1055-9965.epi-038-3.Peer-Reviewed Original ResearchConceptsLung cancer riskCancer riskRelative riskCohort studyLung cancerRisk factorsIncident lung cancer casesBeta-cryptoxanthin intakeMultivariate relative riskBeta-carotene intakeStrong risk factorLung cancer casesPotential risk factorsLutein/zeaxanthinRandom-effects modelDietary questionnaireCurrent smokersMultivitamin useHistological typeIntervention trialsPooled analysisEpidemiological evidenceCancer casesCarotenoid intakeFood composition databases
2003
Premenopausal dietary carbohydrate, glycemic index, glycemic load, and fiber in relation to risk of breast cancer.
Cho E, Spiegelman D, Hunter DJ, Chen WY, Colditz GA, Willett WC. Premenopausal dietary carbohydrate, glycemic index, glycemic load, and fiber in relation to risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 1153-8. PMID: 14652274.Peer-Reviewed Original ResearchConceptsBody mass indexBreast cancer riskHealth Study IIGlycemic loadCarbohydrate intakeCancer riskBreast cancerGlycemic indexDietary carbohydrateRelative riskFiber intakeNurses' Health Study IIMultivariate relative riskCorresponding relative risksFood frequency questionnaireInvasive breast cancerDietary carbohydrate intakeEarly adult lifeYoung adult womenPremenopausal womenFrequency questionnaireLean womenOverall cohortOverweight womenMass indexJoint Association of Alcohol and Folate Intake with Risk of Major Chronic Disease in Women
Jiang R, Hu FB, Giovannucci EL, Rimm EB, Stampfer MJ, Spiegelman D, Rosner BA, Willett WC. Joint Association of Alcohol and Folate Intake with Risk of Major Chronic Disease in Women. American Journal Of Epidemiology 2003, 158: 760-771. PMID: 14561666, DOI: 10.1093/aje/kwg221.Peer-Reviewed Original ResearchConceptsMajor chronic diseasesFolate intakeChronic diseasesCardiovascular diseaseLower total folate intakeJoint associationsMultivariate relative riskNonfatal cardiovascular diseaseTotal folate intakeHigh folate intakeAdequate folate intakeAge 60 yearsLow folate intakePrimary preventionNontraumatic deathsRelative riskHigh riskPrevious historyDietary dataHeavy drinkersNew casesYoung womenDiseaseHeavy drinkingIntakePremenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer.
Cho E, Spiegelman D, Hunter DJ, Chen WY, Zhang SM, Colditz GA, Willett WC. Premenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 713-20. PMID: 12917201.Peer-Reviewed Original ResearchConceptsHealth Study IIBreast cancer riskBreast cancerVitamin ACancer riskNurses' Health Study IIMultivariate relative riskFood frequency questionnaireInvasive breast cancerPrevious epidemiological studiesEarly adult lifePostmenopausal womenPremenopausal womenIncident casesHighest quintileLowest quintileRelative riskHigh intakeEpidemiological studiesNutrient intakeTotal vitaminCancerStudy IIIntakeVitamin C
2002
Coffee intake is associated with lower risk of symptomatic gallstone disease in women
Leitzmann MF, Stampfer MJ, Willett WC, Spiegelman D, Colditz GA, Giovannucci EL. Coffee intake is associated with lower risk of symptomatic gallstone disease in women. Gastroenterology 2002, 123: 1823-1830. PMID: 12454839, DOI: 10.1053/gast.2002.37054.Peer-Reviewed Original ResearchConceptsSymptomatic gallstone diseaseMultivariate relative riskGallstone diseaseRelative riskCoffee drinkingCaffeinated coffeeLower riskRisk of cholecystectomyCoffee intakeCaffeine intakeCoffee consumptionCholecystectomyAge 34Consistent intakeDecaffeinated coffeeAbstractTextDiseaseWomenDietary sourcesIntakeRiskAIMSDrinkingCohortYearsIntakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk
Zhang SM, Hernán MA, Chen H, Spiegelman D, Willett WC, Ascherio A. Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk. Neurology 2002, 59: 1161-1169. PMID: 12391343, DOI: 10.1212/01.wnl.0000028688.75881.12.Peer-Reviewed Original ResearchConceptsRisk of PDVitamin E intakeVitamin EHigh intakeVitamin supplementsE intakeRelative riskHealth StudyHigher dietary vitamin E intakeHigh vitamin E intakePooled multivariate relative risksDietary vitamin E intakeSemiquantitative food frequency questionnaireMultivariate relative riskIncident PD casesNurses' Health StudyFood frequency questionnaireDietary vitamin CDietary vitamin EVitamin C supplementsPathogenesis of PDConsumption of nutsFrequency questionnaireConstituents of foodsHighest quintileIntake of alcohol and alcoholic beverages and the risk of basal cell carcinoma of the skin.
Fung TT, Hunter DJ, Spiegelman D, Colditz GA, Rimm EB, Willett WC. Intake of alcohol and alcoholic beverages and the risk of basal cell carcinoma of the skin. Cancer Epidemiology Biomarkers & Prevention 2002, 11: 1119-22. PMID: 12376519.Peer-Reviewed Original ResearchConceptsAlcohol intakeSun sensitivity factorsMultivariate relative riskTotal alcohol intakeFood frequency questionnaireRisk of BCCBasal cell carcinomaIntake of alcoholPooled logistic regressionAlcoholic beveragesLast physical examinationCases of BCCFrequency questionnaireMultivitamin useSignificant positive associationCell carcinomaPhysical examinationInverse associationRelative riskLarge cohortSun exposureOutdoor walkingLogistic regressionIntakeMore alcoholVitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States)
Fung TT, Hunter DJ, Spiegelman D, Colditz GA, Speizer FE, Willett WC. Vitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States). Cancer Causes & Control 2002, 13: 221-230. PMID: 12020103, DOI: 10.1023/a:1015036317596.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAscorbic AcidCarcinoma, Basal CellCarotenoidsCohort StudiesConfidence IntervalsDietDietary SupplementsFemaleHumansIncidenceLogistic ModelsMiddle AgedProbabilityProspective StudiesRisk AssessmentSensitivity and SpecificitySkin NeoplasmsUnited StatesVitamin AVitamin EVitaminsConceptsBasal cell carcinomaVitamin ACell carcinomaDietary intakeRelative riskSun sensitivity factorsMultivariate relative riskFood frequency questionnaireRisk of BCCSignificant inverse associationIncidence of BCCImportant protective roleFirst diagnosisDietary factorsInverse associationSun exposureLatency periodProtective roleSpecific carotenoidsLogistic regressionVitamin CBottom quintileIntakeCarcinomaRisk
2001
Intakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women
Zhang SM, Hernán MA, Olek MJ, Spiegelman D, Willett WC, Ascherio A. Intakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women. Neurology 2001, 57: 75-80. PMID: 11445631, DOI: 10.1212/wnl.57.1.75.Peer-Reviewed Original ResearchConceptsRisk of MSVitamin EVitamin CLarge cohortSemiquantitative food frequency questionnaireRecent case-control studyAssociation of intakeMultivariate relative riskVitamin C intakeFood frequency questionnaireIntake of carotenoidsIntake of fruitsDietary vitamin CTotal energy intakeDietary vitamin E.Case-control studyLutein/zeaxanthinCases of MSFrequency questionnaireC intakeMS riskMultivitamin supplementsAntioxidant nutrientsHighest quintileLowest quintileProspective Study of Zinc Intake and the Risk of Age-Related Macular Degeneration
Cho E, Stampfer M, Seddon J, Hung S, Spiegelman D, Rimm E, Willett W, Hankinson S. Prospective Study of Zinc Intake and the Risk of Age-Related Macular Degeneration. Annals Of Epidemiology 2001, 11: 328-336. PMID: 11399447, DOI: 10.1016/s1047-2797(01)00217-4.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationZinc intakeRelative riskProspective studyLowest quintileMacular degenerationRisk of AMDDiagnosis of AMDSemiquantitative food frequency questionnaireMultivariate relative riskPooled relative riskFood frequency questionnaireLarge prospective studiesDietary zinc intakeVisual acuity lossTotal zinc intakePotential risk factorsRisk of AgeMultivariate adjustmentIncident casesAcuity lossHighest quintileLong-term benefitsRisk factorsZinc supplementsHouse Dust Endotoxin and Wheeze in the First Year of Life
PARK J, GOLD D, SPIEGELMAN D, BURGE H, MILTON D. House Dust Endotoxin and Wheeze in the First Year of Life. American Journal Of Respiratory And Critical Care Medicine 2001, 163: 322-328. PMID: 11179100, DOI: 10.1164/ajrccm.163.2.2002088.Peer-Reviewed Original ResearchConceptsElevated endotoxinEndotoxin exposureMultivariate modelLower respiratory illnessMultivariate relative riskHistory of asthmaLow birth weightSignificant univariate associationsFirst yearHouse dust endotoxinRoom dustRace/ethnicityMaternal asthmaPrimary outcomeRespiratory illnessAbove covariatesBirth weightDust endotoxinRelative riskCockroach allergensUnivariate associationsFamilial predispositionBedroom floorWheezeBirth cohortProspective study of dietary fat and the risk of age-related macular degeneration 1 , 2 , 3
Cho E, Hung S, Willett W, Spiegelman D, Rimm E, Seddon J, Colditz G, Hankinson S. Prospective study of dietary fat and the risk of age-related macular degeneration 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 73: 209-218. PMID: 11157315, DOI: 10.1093/ajcn/73.2.209.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationRisk of AMDTotal fat intakeFat intakeRelative riskHealth StudyPooled multivariate relative risksDiagnosis of AMDFish/wkModest inverse relationServings/moHealth Professionals FollowMultivariate relative riskNurses' Health StudyFood frequency questionnaireProfessionals FollowStudy of participantsProspective followVisual lossProspective studyLowest quintileDietary fatMacular degenerationHigh intakeLinolenic acid
2000
Electric Blanket Use and Breast Cancer in the Nurses' Health Study
Laden F, Neas LM, Tolbert PE, Holmes MD, Hankinson SE, Spiegelman D, Speizer FE, Hunter DJ. Electric Blanket Use and Breast Cancer in the Nurses' Health Study. American Journal Of Epidemiology 2000, 152: 41-49. PMID: 10901328, DOI: 10.1093/aje/152.1.41.Peer-Reviewed Original ResearchConceptsElectric blanket useNurses' Health StudyBreast cancerHealth StudyBlanket useRelative riskEstrogen receptor-positive breast cancerReceptor-positive breast cancerBreast cancer risk factorsMultivariate relative riskInvasive breast cancerCancer risk factorsAge-adjusted analysesBreast cancer riskLong-term useElectric blanketBiennial questionnairesRisk factorsRetrospective analysisCancer riskProspective analysisCancerMultivariate modelSmall riskConfidence intervals
1999
Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age.
Garland M, Hunter DJ, Colditz GA, Spiegelman DL, Manson JE, Stampfer MJ, Willett WC. Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 1017-21. PMID: 10566558.Peer-Reviewed Original ResearchConceptsBreast cancer riskMultivariate relative riskAlcohol consumptionCancer riskRelative riskBreast cancerDrinks/weekInvasive breast cancerModerate alcohol consumptionMore drinks/weekAverage lifetime alcohol consumptionLifetime alcohol consumptionWomen age 25Past alcohol consumptionYears of agePostmenopausal womenPremenopausal womenWomen 25Age 25Young womenHeavy drinkingAge 23Drinking levelsWomenFurther studiesRecreational Physical Activity and the Risk of Cholecystectomy in Women
Leitzmann M, Rimm E, Willett W, Spiegelman D, Grodstein F, Stampfer M, Colditz G, Giovannucci E. Recreational Physical Activity and the Risk of Cholecystectomy in Women. New England Journal Of Medicine 1999, 341: 777-784. PMID: 10477775, DOI: 10.1056/nejm199909093411101.Peer-Reviewed Original ResearchConceptsRisk of cholecystectomyRecreational physical activityMultivariate relative riskPhysical activityGallstone diseaseRelative riskSedentary behaviorHealth StudyBody weightCases of cholecystectomyRecent weight lossNurses' Health StudyYears of ageSymptomatic cholelithiasisDecreased riskLowest quintileRisk factorsCholecystectomyWeight lossWeight changeWomenDiseaseActivity levelsWeeksRiskFluid Intake and the Risk of Bladder Cancer in Men
Michaud D, Spiegelman D, Clinton S, Rimm E, Curhan G, Willett W, Giovannucci E. Fluid Intake and the Risk of Bladder Cancer in Men. New England Journal Of Medicine 1999, 340: 1390-1397. PMID: 10228189, DOI: 10.1056/nejm199905063401803.Peer-Reviewed Original ResearchConceptsTotal fluid intakeTotal daily fluid intakeDaily fluid intakeBladder cancerFluid intakeMultivariate relative riskFood frequency questionnaireFrequency of voidingHigh fluid intakeLogistic regression analysisProspective Health ProfessionalsFrequency of urinationFrequency of consumptionDecreased riskHighest quintileType of beverageLowest quintileRisk factorsRelative riskLower riskUrinary metabolitesHealth professionalsCancerIntakeRisk
1998
Risk of Uterine Leiomyomata among Premenopausal Women in Relation to Body Size and Cigarette Smoking
Marshall L, Spiegelman D, Manson J, Goldman M, Barbieri R, Stampfer M, Willett W, Hunter D. Risk of Uterine Leiomyomata among Premenopausal Women in Relation to Body Size and Cigarette Smoking. Epidemiology 1998, 9: 511-517. PMID: 9730029, DOI: 10.1097/00001648-199809000-00007.Peer-Reviewed Original ResearchConceptsBody mass indexAdult body mass indexMass indexCigarette smokingUterine leiomyomataAge 18 yearsPremenopausal womenRelative riskBody mass index categoriesMultivariate relative riskConfidence intervalsIntact uterusOvarian functionNew diagnosisLeiomyomataIndex categoriesSmokingStudy questionnaireNew casesHysterectomyAge 25Weight gainWeight changeWomenRisk