2011
Serotype replacement in disease after pneumococcal vaccination
Weinberger DM, Malley R, Lipsitch M. Serotype replacement in disease after pneumococcal vaccination. The Lancet 2011, 378: 1962-1973. PMID: 21492929, PMCID: PMC3256741, DOI: 10.1016/s0140-6736(10)62225-8.Peer-Reviewed Original ResearchConceptsNon-vaccine serotypesSerotype replacementPneumococcal diseaseHeptavalent pneumococcal conjugate vaccinePneumococcal conjugate vaccineImportant public health benefitsBenefits of vaccinationPublic health benefitsDisease surveillance systemsNVT carriagePneumococcal vaccinationSurveillance biasesConjugate vaccineVaccine serotypesCarriage prevalencePneumococcal serotypesAsymptomatic carriersCarriage dataDiseaseVaccinationHealth benefitsLow invasivenessPrevalenceSerotypesCarriage
2009
Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence
Weinberger DM, Trzciński K, Lu YJ, Bogaert D, Brandes A, Galagan J, Anderson PW, Malley R, Lipsitch M. Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence. PLOS Pathogens 2009, 5: e1000476. PMID: 19521509, PMCID: PMC2689349, DOI: 10.1371/journal.ppat.1000476.Peer-Reviewed Original ResearchConceptsSerotype replacementCarriage prevalenceNasopharyngeal carriageCapsular serotypesNon-vaccine serotypesNeutrophil-mediated killingNasopharyngeal carriage prevalenceCapsular polysaccharideVaccinated populationSerotype prevalenceEpidemiological patternsPrevalent serotypesStreptococcus pneumoniaeBacterial factorsParticular serotypePrevalenceImportant serotypesNovel biological principleSerotypesDifferent serotypesCarriageNeutrophilsBiological differencesKillingVaccination