2024
Clonal Expansion of a Streptococcus pneumoniae Serotype 3 Capsule Variant Sequence Type 700 With Enhanced Vaccine Escape Potential After 13-Valent Pneumococcal Conjugate Vaccine Introduction
Kalizang'oma A, Swarthout T, Mwalukomo T, Kamng'ona A, Brown C, Msefula J, Demetriou H, Chan J, Roalfe L, Obolski U, Lourenço J, Goldblatt D, Chaguza C, French N, Heyderman R. Clonal Expansion of a Streptococcus pneumoniae Serotype 3 Capsule Variant Sequence Type 700 With Enhanced Vaccine Escape Potential After 13-Valent Pneumococcal Conjugate Vaccine Introduction. The Journal Of Infectious Diseases 2024, jiae040. PMID: 38530917, DOI: 10.1093/infdis/jiae040.Peer-Reviewed Original ResearchClonal expansionSequence typingAntimicrobial resistanceSusceptibility to opsonophagocytic killingWhole-genome sequencingStreptococcus pneumoniae serotype 3Serotype 3Post-PCV13 introductionNext-generation pneumococcal vaccinesPneumococcal conjugate vaccine introductionVaccine escapeConjugate vaccine introductionPneumococcal conjugate vaccineIncreased antimicrobial resistancePolysaccharide biosynthesisPhylogenetic reconstructionSequencing projectsLocus sequencesCapsule locusSequence clustersGenomic surveillanceOpsonophagocytic killingPhenotypic characteristicsVaccine introductionConjugate vaccine
2020
Rotavirus Genotypes in Hospitalized Children With Acute Gastroenteritis Before and After Rotavirus Vaccine Introduction in Blantyre, Malawi, 1997–2019
Mhango C, Mandolo JJ, Chinyama E, Wachepa R, Kanjerwa O, Malamba-Banda C, Matambo PB, Barnes KG, Chaguza C, Shawa IT, Nyaga MM, Hungerford D, Parashar UD, Pitzer VE, Kamng'ona A, Iturriza-Gomara M, Cunliffe NA, Jere KC. Rotavirus Genotypes in Hospitalized Children With Acute Gastroenteritis Before and After Rotavirus Vaccine Introduction in Blantyre, Malawi, 1997–2019. The Journal Of Infectious Diseases 2020, 225: 2127-2136. PMID: 33033832, PMCID: PMC9200156, DOI: 10.1093/infdis/jiaa616.Peer-Reviewed Original ResearchConceptsRV1 introductionRotavirus genotypesRotavirus-positive stool specimensDiarrhea-associated hospitalizationsRotavirus vaccine introductionReverse transcription-polymerase chain reactionRotavirus strain diversityPostvaccine periodRotavirus vaccineVaccine introductionHospitalized childrenPolymerase chain reactionStool specimensAcute gastroenteritisP genotypesPrevalent genotypeRotavirus GVaccine pressurePredominant genotypeChain reactionBlantyreStrain diversityChildrenGenotypesYears
2018
Emergence of Double- and Triple-Gene Reassortant G1P[8] Rotaviruses Possessing a DS-1-Like Backbone after Rotavirus Vaccine Introduction in Malawi
Jere KC, Chaguza C, Bar-Zeev N, Lowe J, Peno C, Kumwenda B, Nakagomi O, Tate JE, Parashar UD, Heyderman RS, French N, Cunliffe NA, Iturriza-Gomara M. Emergence of Double- and Triple-Gene Reassortant G1P[8] Rotaviruses Possessing a DS-1-Like Backbone after Rotavirus Vaccine Introduction in Malawi. Journal Of Virology 2018, 92: e01246-17. PMID: 29142125, PMCID: PMC5774894, DOI: 10.1128/jvi.01246-17.Peer-Reviewed Original ResearchConceptsRotavirus vaccineVaccine introductionVaccine effectivenessVaccine-induced neutralizing antibodiesMultiple African countriesRotavirus gastroenteritis casesRotavirus vaccine introductionChildhood immunization programsCareful evaluationVaccine escape mutantsDS-1-like backboneSuch atypical strainsRotavirus gastroenteritisImmunization scheduleNeutralizing antibodiesAmino acid substitutionsImmunization programsPostvaccine eraHigh burdenGastroenteritis casesImmune evasionEscape mutantsHuman WaDS-1-like rotavirusesRotavirus