2024
Clonal Expansion of a Streptococcus pneumoniae Serotype 3 Capsule Variant Sequence Type 700 With Enhanced Vaccine Escape Potential After 13-Valent Pneumococcal Conjugate Vaccine Introduction
Kalizang'oma A, Swarthout T, Mwalukomo T, Kamng'ona A, Brown C, Msefula J, Demetriou H, Chan J, Roalfe L, Obolski U, Lourenço J, Goldblatt D, Chaguza C, French N, Heyderman R. Clonal Expansion of a Streptococcus pneumoniae Serotype 3 Capsule Variant Sequence Type 700 With Enhanced Vaccine Escape Potential After 13-Valent Pneumococcal Conjugate Vaccine Introduction. The Journal Of Infectious Diseases 2024, jiae040. PMID: 38530917, DOI: 10.1093/infdis/jiae040.Peer-Reviewed Original ResearchClonal expansionSequence typingAntimicrobial resistanceSusceptibility to opsonophagocytic killingWhole-genome sequencingStreptococcus pneumoniae serotype 3Serotype 3Post-PCV13 introductionNext-generation pneumococcal vaccinesPneumococcal conjugate vaccine introductionVaccine escapeConjugate vaccine introductionPneumococcal conjugate vaccineIncreased antimicrobial resistancePolysaccharide biosynthesisPhylogenetic reconstructionSequencing projectsLocus sequencesCapsule locusSequence clustersGenomic surveillanceOpsonophagocytic killingPhenotypic characteristicsVaccine introductionConjugate vaccine
2022
Novel Multilocus Sequence Typing and Global Sequence Clustering Schemes for Characterizing the Population Diversity of Streptococcus mitis
Kalizang’oma A, Kwambana-Adams B, Chan J, Viswanath A, Gori A, Richard D, Jolley K, Lees J, Goldblatt D, Beleza S, Bentley S, Heyderman R, Chaguza C. Novel Multilocus Sequence Typing and Global Sequence Clustering Schemes for Characterizing the Population Diversity of Streptococcus mitis. Journal Of Clinical Microbiology 2022, 61: e00802-22. PMID: 36515506, PMCID: PMC9879099, DOI: 10.1128/jcm.00802-22.Peer-Reviewed Original ResearchConceptsSequence clustersPathogenic streptococcal speciesMultilocus sequence typing (MLST) schemePopulation diversitySingle-nucleotide polymorphism distancesSequence typesSequence typing schemeUnique sequence typesGenetic diversityPopulation structureBacterial population diversityMolecular typing toolsS. mitisHousekeeping genesSequence fragmentsMLST schemeDiversityOpportunistic pathogenStreptococcus mitisStreptococcal speciesTyping toolSpeciesNew insightsTyping schemeMultilocus sequence typing