Featured Publications
Recombination in Streptococcus pneumoniae Lineages Increase with Carriage Duration and Size of the Polysaccharide Capsule
Chaguza C, Andam CP, Harris SR, Cornick JE, Yang M, Bricio-Moreno L, Kamng’ona A, Parkhill J, French N, Heyderman RS, Kadioglu A, Everett DB, Bentley SD, Hanage WP. Recombination in Streptococcus pneumoniae Lineages Increase with Carriage Duration and Size of the Polysaccharide Capsule. MBio 2016, 7: e01053-16. PMID: 27677790, PMCID: PMC5040112, DOI: 10.1128/mbio.01053-16.Peer-Reviewed Original ResearchPneumococcal conjugate vaccineInvasive pneumococcal diseasePrevalence of carriageCarriage durationCarriage prevalenceComplex polysaccharide capsulePolysaccharide capsuleVaccine escape variantsSerotype-specific responsesDifferent pneumococcal serotypesResource-poor settingsLonger carriage durationPneumococcal diseaseConjugate vaccinePneumococcal serotypesEscape variantsUnivariate analysisHigh burdenMultivariate analysisStreptococcus pneumoniaeDrug resistanceClinical interventionsPneumococciPrevalenceVaccine
2017
Genomic Epidemiology of Penicillin-Nonsusceptible Pneumococci with Nonvaccine Serotypes Causing Invasive Disease in the United States
Andam CP, Mitchell PK, Callendrello A, Chang Q, Corander J, Chaguza C, McGee L, Beall BW, Hanage WP. Genomic Epidemiology of Penicillin-Nonsusceptible Pneumococci with Nonvaccine Serotypes Causing Invasive Disease in the United States. Journal Of Clinical Microbiology 2017, 55: 1104-1115. PMID: 28100596, PMCID: PMC5377837, DOI: 10.1128/jcm.02453-16.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolEpidemiological MonitoringEvolution, MolecularFemaleGenome, BacterialGenotypeHumansInfantInfant, NewbornMaleMiddle AgedMolecular EpidemiologyPenicillin ResistancePneumococcal InfectionsSequence Analysis, DNASerogroupStreptococcus pneumoniaeUnited StatesYoung AdultConceptsActive Bacterial Core surveillancePneumococcal Molecular Epidemiology NetworkNonvaccine typesVaccine typesPenicillin-nonsusceptible pneumococciAntibiotic-resistant strainsNVT pneumococciNonvaccine serotypesSerotype 35BPneumococcal serotypesInvasive diseaseSerogroups 23Core surveillanceEpidemiology NetworkDisease controlDisease prevalencePNSPGenomic epidemiologyFuture surveillanceVaccinationSerotypesResistant clonesSerotype switchingPneumococciDisease
2015
Comparative Genomic Analysis of Meningitis- and Bacteremia-Causing Pneumococci Identifies a Common Core Genome
Kulohoma BW, Cornick JE, Chaguza C, Yalcin F, Harris SR, Gray KJ, Kiran AM, Molyneux E, French N, Parkhill J, Faragher BE, Everett DB, Bentley SD, Heyderman RS. Comparative Genomic Analysis of Meningitis- and Bacteremia-Causing Pneumococci Identifies a Common Core Genome. Infection And Immunity 2015, 83: 4165-4173. PMID: 26259813, PMCID: PMC4567637, DOI: 10.1128/iai.00814-15.Peer-Reviewed Original ResearchConceptsBloodstream infectionsSterile sitesPneumococcal population structureDisease manifestationsMeningitisVaccine candidatesS. pneumoniaeStreptococcus pneumoniaeNasopharyngeal commensalPneumococciVirulence factorsWhole-genome sequencingInfectionPneumoniaeVirulence behaviorPresence/absenceIsolatesMeninges