2024
Genetic markers associated with host status and clonal expansion of Group B Streptococcus in the Netherlands
Khan U, Dyster V, Chaguza C, van Sorge N, van de Beek D, Man K, Bentley S, Bijlsma M, Jamrozy D. Genetic markers associated with host status and clonal expansion of Group B Streptococcus in the Netherlands. Frontiers In Microbiology 2024, 15: 1410651. DOI: 10.3389/fmicb.2024.1410651.Peer-Reviewed Original ResearchGroup B streptococciDisease isolatesCarriage isolatesCC17 isolatesClonal complexesDistribution of genetic markersPrevalence of antimicrobial resistance genesWhole-genome sequencingMobile genetic elementsAntimicrobial resistance genesAssociated with invasive diseaseGBS populationB streptococciInvasive diseaseClonal expansion eventsGenome sequenceExpansion eventsGenetic elementsGenomic analysisGenetic markersResistance genesSub-lineagesInvasive isolatesSerotype IIHost groups
2023
Comparative whole genome analysis reveals re-emergence of human Wa-like and DS-1-like G3 rotaviruses after Rotarix vaccine introduction in Malawi
Mhango C, Banda A, Chinyama E, Mandolo J, Kumwenda O, Malamba-Banda C, Barnes K, Kumwenda B, Jambo K, Donato C, Esona M, Mwangi P, Steele A, Iturriza-Gomara M, Cunliffe N, Ndze V, Kamng'ona A, Dennis F, Nyaga M, Chaguza C, Jere K. Comparative whole genome analysis reveals re-emergence of human Wa-like and DS-1-like G3 rotaviruses after Rotarix vaccine introduction in Malawi. Virus Evolution 2023, 9: vead030. PMID: 37305707, PMCID: PMC10256189, DOI: 10.1093/ve/vead030.Peer-Reviewed Original ResearchBackbone genesComparative whole genome analysisFurther genomic analysisGenotype constellationRecent common ancestorWhole genome sequencesWhole-genome analysisAmino acid substitutionsCommon ancestorPhylogenetic treeGenome sequenceGenome analysisGenomic analysisInterspecies reassortmentGenetic similarityGenome segmentsNSP2 geneAcid substitutionsReassortment eventsAcid segmentGenesVP4 proteinG3 rotavirusesG3 strainsHuman Wa