Featured Publications
Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation
Chaguza C, Senghore M, Bojang E, Gladstone RA, Lo SW, Tientcheu PE, Bancroft RE, Worwui A, Foster-Nyarko E, Ceesay F, Okoi C, McGee L, Klugman KP, Breiman RF, Barer MR, Adegbola RA, Antonio M, Bentley SD, Kwambana-Adams BA. Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation. Nature Communications 2020, 11: 3442. PMID: 32651390, PMCID: PMC7351774, DOI: 10.1038/s41467-020-17327-w.Peer-Reviewed Original ResearchConceptsNatural colonisationHost microevolutionNucleotide substitution ratesWhole-genome sequencingGenomic evolutionNeutral evolutionGenetic diversityHomologous recombinationParallel evolutionGenomic changesAdhesion genesSubstitution ratesHuman-adapted pathogenMicroevolutionStrain variantsColonisationImmune evasionStreptococcus pneumoniaeAntibiotic resistanceGenesEvolutionSequencingDiversityNasopharyngeal carriageBacteria
2023
Comparative whole genome analysis reveals re-emergence of human Wa-like and DS-1-like G3 rotaviruses after Rotarix vaccine introduction in Malawi
Mhango C, Banda A, Chinyama E, Mandolo J, Kumwenda O, Malamba-Banda C, Barnes K, Kumwenda B, Jambo K, Donato C, Esona M, Mwangi P, Steele A, Iturriza-Gomara M, Cunliffe N, Ndze V, Kamng'ona A, Dennis F, Nyaga M, Chaguza C, Jere K. Comparative whole genome analysis reveals re-emergence of human Wa-like and DS-1-like G3 rotaviruses after Rotarix vaccine introduction in Malawi. Virus Evolution 2023, 9: vead030. PMID: 37305707, PMCID: PMC10256189, DOI: 10.1093/ve/vead030.Peer-Reviewed Original ResearchBackbone genesComparative whole genome analysisFurther genomic analysisGenotype constellationRecent common ancestorWhole genome sequencesWhole-genome analysisAmino acid substitutionsCommon ancestorPhylogenetic treeGenome sequenceGenome analysisGenomic analysisInterspecies reassortmentGenetic similarityGenome segmentsNSP2 geneAcid substitutionsReassortment eventsAcid segmentGenesVP4 proteinG3 rotavirusesG3 strainsHuman Wa