2016
Molecular surveillance on Streptococcus pneumoniae carriage in non-elderly adults; little evidence for pneumococcal circulation independent from the reservoir in children
Wyllie AL, Rümke LW, Arp K, Bosch AA, Bruin JP, Rots NY, Wijmenga-Monsuur AJ, Sanders EA, Trzciński K. Molecular surveillance on Streptococcus pneumoniae carriage in non-elderly adults; little evidence for pneumococcal circulation independent from the reservoir in children. Scientific Reports 2016, 6: 34888. PMID: 27713565, PMCID: PMC5054371, DOI: 10.1038/srep34888.Peer-Reviewed Original ResearchConceptsCarriage rateNasopharyngeal swabsOral samplesUpper respiratory tract samplesVaccine herd effectsStreptococcus pneumoniae carriageRespiratory tract samplesHigh carriage rateNon-elderly adultsS. pneumoniae detectionAge-associated differencesEntire adult populationChildless adultsSerotype replacementPneumoniae carriagePneumococcal carriageTract samplesCarriage frequencyStreptococcus pneumoniaeAdult populationSerotype 3Gold standard culture methodMolecular surveillanceMolecular testsGold standard
2013
Superiority of Trans-Oral over Trans-Nasal Sampling in Detecting Streptococcus pneumoniae Colonization in Adults
Trzciński K, Bogaert D, Wyllie A, Chu ML, van der Ende A, Bruin JP, van den Dobbelsteen G, Veenhoven RH, Sanders EA. Superiority of Trans-Oral over Trans-Nasal Sampling in Detecting Streptococcus pneumoniae Colonization in Adults. PLOS ONE 2013, 8: e60520. PMID: 23555985, PMCID: PMC3610877, DOI: 10.1371/journal.pone.0060520.Peer-Reviewed Original ResearchConceptsS. pneumoniaeLive pneumococciDiagnostic stepsTrans-nasal approachStreptococcus pneumoniae colonizationInitial diagnostic stepPneumoniae colonizationNasopharyngeal samplesPneumococcal colonizationNasopharyngeal colonizationStreptococcus pneumoniaeHuman nasopharynxPneumococciPneumoniaeCell harvestAdultsQPCRQPCR resultsMain reservoirMolecular methods