2021
Delayed production of neutralizing antibodies correlates with fatal COVID-19
Lucas C, Klein J, Sundaram ME, Liu F, Wong P, Silva J, Mao T, Oh JE, Mohanty S, Huang J, Tokuyama M, Lu P, Venkataraman A, Park A, Israelow B, Vogels CBF, Muenker MC, Chang CH, Casanovas-Massana A, Moore AJ, Zell J, Fournier JB, Wyllie A, Campbell M, Lee A, Chun H, Grubaugh N, Schulz W, Farhadian S, Dela Cruz C, Ring A, Shaw A, Wisnewski A, Yildirim I, Ko A, Omer S, Iwasaki A. Delayed production of neutralizing antibodies correlates with fatal COVID-19. Nature Medicine 2021, 27: 1178-1186. PMID: 33953384, PMCID: PMC8785364, DOI: 10.1038/s41591-021-01355-0.Peer-Reviewed Original ResearchConceptsDeceased patientsAntibody levelsAntibody responseDisease severityAnti-S IgG levelsCOVID-19 disease outcomesFatal COVID-19Impaired viral controlWorse clinical progressionWorse disease severitySevere COVID-19Length of hospitalizationImmunoglobulin G levelsHumoral immune responseCoronavirus disease 2019COVID-19 mortalityCOVID-19Domain (RBD) IgGSeroconversion kineticsDisease courseIgG levelsClinical parametersClinical progressionHumoral responseDisease onset
2018
Exploring Immune Development in Infants With Moderate to Severe Atopic Dermatitis
Hulshof L, Overbeek SA, Wyllie AL, Chu MLJN, Bogaert D, de Jager W, Knippels LMJ, Sanders EAM, van Aalderen WMC, Garssen J, Land B, Sprikkelman AB, Group T, Blauw A, Dontje B, Duijvestein Y, de Boom W, Groot I, Boks M, van Kooyk Y, Fandri D, Hijnen D, Middelkamp-Hup M, Papi B, Roelofs M, Rijnierse A, Veening D, Support C, Prakken B, Tusscher G, Tupker R, Willemsen L. Exploring Immune Development in Infants With Moderate to Severe Atopic Dermatitis. Frontiers In Immunology 2018, 9: 630. PMID: 29966024, PMCID: PMC5884950, DOI: 10.3389/fimmu.2018.00630.Peer-Reviewed Original ResearchConceptsSevere atopic dermatitisAtopic dermatitisDietary interventionAD severityCommon chronic inflammatory skin diseaseT helper cell type 2Understanding of ADChronic inflammatory skin diseaseCC chemokine ligand 17CXC chemokine ligand 9Serum chemokine levelsSpecific IgE levelsInflammatory skin diseaseChemokine ligand 17Cell type 2Dietary intervention studyWhey-based formulaChemokine ligand 9Post-intervention samplesMonths of ageCCL22 chemokinesTh1 chemokinesTh2 chemokinesChemokine levelsM-16V
2017
Sequencing of the variable region of rpsB to discriminate between Streptococcus pneumoniae and other streptococcal species
Wyllie AL, Pannekoek Y, Bovenkerk S, van Engelsdorp Gastelaars J, Ferwerda B, van de Beek D, Sanders EAM, Trzciński K, van der Ende A. Sequencing of the variable region of rpsB to discriminate between Streptococcus pneumoniae and other streptococcal species. Open Biology 2017, 7: 170074. PMID: 28931649, PMCID: PMC5627049, DOI: 10.1098/rsob.170074.Peer-Reviewed Original ResearchConceptsSevere streptococcal diseaseUpper respiratory tractHuman upper respiratory tractSerotype-specific assaysMolecular assaysStreptococcal speciesNon-typeable pneumococciStreptococcal diseaseAsymptomatic individualsFalse-positive resultsRespiratory tractPneumococcal isolatesCarriage isolatesStreptococcal isolatesStreptococcus pneumoniaeLack of specificityStreptococciPositive resultsPneumococciDiseaseCarriageAssaysIsolatesVast majorityMeningitis