2016
Molecular surveillance on Streptococcus pneumoniae carriage in non-elderly adults; little evidence for pneumococcal circulation independent from the reservoir in children
Wyllie AL, Rümke LW, Arp K, Bosch AA, Bruin JP, Rots NY, Wijmenga-Monsuur AJ, Sanders EA, Trzciński K. Molecular surveillance on Streptococcus pneumoniae carriage in non-elderly adults; little evidence for pneumococcal circulation independent from the reservoir in children. Scientific Reports 2016, 6: 34888. PMID: 27713565, PMCID: PMC5054371, DOI: 10.1038/srep34888.Peer-Reviewed Original ResearchConceptsCarriage rateNasopharyngeal swabsOral samplesUpper respiratory tract samplesVaccine herd effectsStreptococcus pneumoniae carriageRespiratory tract samplesHigh carriage rateNon-elderly adultsS. pneumoniae detectionAge-associated differencesEntire adult populationChildless adultsSerotype replacementPneumoniae carriagePneumococcal carriageTract samplesCarriage frequencyStreptococcus pneumoniaeAdult populationSerotype 3Gold standard culture methodMolecular surveillanceMolecular testsGold standardMolecular surveillance of nasopharyngeal carriage of Streptococcus pneumoniae in children vaccinated with conjugated polysaccharide pneumococcal vaccines
Wyllie AL, Wijmenga-Monsuur AJ, van Houten MA, Bosch AATM, Groot JA, van Engelsdorp Gastelaars J, Bruin JP, Bogaert D, Rots NY, Sanders EAM, Trzciński K. Molecular surveillance of nasopharyngeal carriage of Streptococcus pneumoniae in children vaccinated with conjugated polysaccharide pneumococcal vaccines. Scientific Reports 2016, 6: 23809. PMID: 27046258, PMCID: PMC4820691, DOI: 10.1038/srep23809.Peer-Reviewed Original ResearchConceptsPneumococcal conjugate vaccinePolysaccharide pneumococcal vaccineVaccine-targeted serotypesStreptococcus pneumoniae carriageCross-sectional surveillanceVaccine serotypes 4Number of serotypesPneumococcal surveillancePneumococcal vaccinePneumoniae carriageUnvaccinated individualsConjugate vaccineNasopharyngeal carriagePneumococcal diseaseVaccine effectsNasopharyngeal samplesConventional diagnostic methodsSurveillance studyS. pneumoniaeStreptococcus pneumoniaeSerotype detectionMolecular surveillanceHidden circulationSerotypesDiagnostic methods
2014
Streptococcus pneumoniae in Saliva of Dutch Primary School Children
Wyllie AL, Chu ML, Schellens MH, van Engelsdorp Gastelaars J, Jansen MD, van der Ende A, Bogaert D, Sanders EA, Trzciński K. Streptococcus pneumoniae in Saliva of Dutch Primary School Children. PLOS ONE 2014, 9: e102045. PMID: 25013895, PMCID: PMC4094488, DOI: 10.1371/journal.pone.0102045.Peer-Reviewed Original ResearchConceptsPneumoniae carriagePneumococcal carriagePneumococcal strainsMultiple pneumococcal strainsStreptococcus pneumoniae carriageS. pneumoniae carriageS. pneumoniae strainsNumber of serotypesDutch primary school childrenNasopharyngeal samplingSchool-aged childrenPneumococcal detectionSurveillance studyS. pneumoniaePneumoniae strainsStreptococcus pneumoniaeSerotype composition