2023
Persistence of Pneumococcal Carriage among Older Adults in the Community despite COVID-19 Mitigation Measures
Wyllie A, Mbodj S, Thammavongsa D, Hislop M, Yolda-Carr D, Waghela P, Nakahata M, Stahlfeld A, Vega N, York A, Allicock O, Wilkins G, Ouyang A, Siqueiros L, Strong Y, Anastasio K, Alexander-Parrish R, Arguedas A, Gessner B, Weinberger D. Persistence of Pneumococcal Carriage among Older Adults in the Community despite COVID-19 Mitigation Measures. Microbiology Spectrum 2023, 11: e04879-22. PMID: 37036377, PMCID: PMC10269788, DOI: 10.1128/spectrum.04879-22.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePneumococcal diseaseSchool-aged childrenOlder adultsPneumococcal carriageSaliva samplesCOVID-19 pandemicRate of carriageCOVID-19-related disruptionsUpper respiratory tractRegular contactNew Haven areaFirst yearCarriage prevalencePre-pandemic levelsMedical historyRespiratory tractHigh prevalenceStreptococcus pneumoniaeCOVID-19 mitigation measuresStudy participantsPneumococciPrevalenceDiseaseCarriage
2021
1321. Acquisition and Transmission of Streptococcus pneumoniae in Individuals Over the Age of 60 Years Residing in New Haven, CT, USA
Wyllie A, Mbodj S, Yolda-Carr D, Thammavongsa D, Waghela P, Nakahata M, Vega N, York A, Allicock O, Alexander-Parrish R, Arguedas A, Gessner B, Weinberger D, Hislop M. 1321. Acquisition and Transmission of Streptococcus pneumoniae in Individuals Over the Age of 60 Years Residing in New Haven, CT, USA. Open Forum Infectious Diseases 2021, 8: 749-749. PMCID: PMC8689704, DOI: 10.1093/ofid/ofab466.1513.Peer-Reviewed Original ResearchPneumococcal carriageSaliva samplesOlder adultsPreventative public health measuresPneumococcal conjugate vaccineNew Haven areaPublic health measuresPneumococcal acquisitionPneumococcal diseaseConjugate vaccinePneumococcal transmissionStudy enrollmentMedical historyImportant burdenDemonstrate evidenceStreptococcus pneumoniaeHealth measuresMultiple timepointsTime pointsWeeksAdultsCOVID-19 pandemicAgeHigh ratePneumococci
2020
Serotype Patterns of Pneumococcal Disease in Adults Are Correlated With Carriage Patterns in Older Children
Wyllie AL, Warren JL, Regev-Yochay G, Givon-Lavi N, Dagan R, Weinberger DM. Serotype Patterns of Pneumococcal Disease in Adults Are Correlated With Carriage Patterns in Older Children. Clinical Infectious Diseases 2020, 72: e768-e775. PMID: 32989457, PMCID: PMC8315131, DOI: 10.1093/cid/ciaa1480.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseSerotype-specific invasive pneumococcal diseaseDisease patternsOlder childrenPneumococcal diseasePneumococcal carriageCarriage prevalenceSerotype patternsCause of IPDIPD dataSerotype-specific carriage prevalenceAge groupingsDifferent age groupsComorbidity statusDisease burdenVaccination strategiesAge-related patternsCarriage dataCarriage patternsDifferent age categoriesAge groupsSpecific serotypesYoung adultsAdultsAge categories
2016
Molecular surveillance of nasopharyngeal carriage of Streptococcus pneumoniae in children vaccinated with conjugated polysaccharide pneumococcal vaccines
Wyllie AL, Wijmenga-Monsuur AJ, van Houten MA, Bosch AATM, Groot JA, van Engelsdorp Gastelaars J, Bruin JP, Bogaert D, Rots NY, Sanders EAM, Trzciński K. Molecular surveillance of nasopharyngeal carriage of Streptococcus pneumoniae in children vaccinated with conjugated polysaccharide pneumococcal vaccines. Scientific Reports 2016, 6: 23809. PMID: 27046258, PMCID: PMC4820691, DOI: 10.1038/srep23809.Peer-Reviewed Original ResearchConceptsPneumococcal conjugate vaccinePolysaccharide pneumococcal vaccineVaccine-targeted serotypesStreptococcus pneumoniae carriageCross-sectional surveillanceVaccine serotypes 4Number of serotypesPneumococcal surveillancePneumococcal vaccinePneumoniae carriageUnvaccinated individualsConjugate vaccineNasopharyngeal carriagePneumococcal diseaseVaccine effectsNasopharyngeal samplesConventional diagnostic methodsSurveillance studyS. pneumoniaeStreptococcus pneumoniaeSerotype detectionMolecular surveillanceHidden circulationSerotypesDiagnostic methods
2015
Carriage of Streptococcus pneumoniae in Aged Adults with Influenza-Like-Illness
Krone CL, Wyllie AL, van Beek J, Rots NY, Oja AE, Chu ML, Bruin JP, Bogaert D, Sanders EA, Trzciński K. Carriage of Streptococcus pneumoniae in Aged Adults with Influenza-Like-Illness. PLOS ONE 2015, 10: e0119875. PMID: 25789854, PMCID: PMC4366201, DOI: 10.1371/journal.pone.0119875.Peer-Reviewed Original ResearchConceptsS. pneumoniaeStreptococcus pneumoniaeCarriage detectionSaliva samplesPneumococcal conjugated vaccineStudy time pointsPCV13 serotypesPneumococcal diseaseCarriage prevalenceNasopharyngeal colonisationNasopharyngeal swabsConjugated vaccineNasopharyngealAged adultsPneumococciTime pointsPneumoniaeCarriageInfantsConventional cultureIllnessSalivaInfluenzaDiseaseSerotypes