2024
Serological Profiling of Pneumococcal Proteins Reveals Unique Patterns of Acquisition, Maintenance, and Waning of Antibodies Throughout Life
He S, Voß F, Nicolaie M, Brummelman J, van de Garde M, Bijvank E, Poelen M, Wijmenga-Monsuur A, Wyllie A, Trzciński K, Van Beek J, Rots N, Hartog G, Hammerschmidt S, van C. Serological Profiling of Pneumococcal Proteins Reveals Unique Patterns of Acquisition, Maintenance, and Waning of Antibodies Throughout Life. The Journal Of Infectious Diseases 2024, jiae216. PMID: 38679601, DOI: 10.1093/infdis/jiae216.Peer-Reviewed Original ResearchIgG levelsPneumococcal proteinsAntibody responseLow IgG levelsSerum IgG levelsWaning of antibodiesIncreased IgG levelsAdults aged >Age-targeted interventionsProtein-specific antibody responsesPneumococcal carriageOlder adults aged >Streptococcus pneumoniaeSerological profileOlder infantsOlder ageOlder childrenOlder adultsAntibodiesAgeCarriageAdultsChildrenUnique pattern
2020
Serotype Patterns of Pneumococcal Disease in Adults Are Correlated With Carriage Patterns in Older Children
Wyllie AL, Warren JL, Regev-Yochay G, Givon-Lavi N, Dagan R, Weinberger DM. Serotype Patterns of Pneumococcal Disease in Adults Are Correlated With Carriage Patterns in Older Children. Clinical Infectious Diseases 2020, 72: e768-e775. PMID: 32989457, PMCID: PMC8315131, DOI: 10.1093/cid/ciaa1480.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseSerotype-specific invasive pneumococcal diseaseDisease patternsOlder childrenPneumococcal diseasePneumococcal carriageCarriage prevalenceSerotype patternsCause of IPDIPD dataSerotype-specific carriage prevalenceAge groupingsDifferent age groupsComorbidity statusDisease burdenVaccination strategiesAge-related patternsCarriage dataCarriage patternsDifferent age categoriesAge groupsSpecific serotypesYoung adultsAdultsAge categories