2016
Molecular surveillance of nasopharyngeal carriage of Streptococcus pneumoniae in children vaccinated with conjugated polysaccharide pneumococcal vaccines
Wyllie AL, Wijmenga-Monsuur AJ, van Houten MA, Bosch AATM, Groot JA, van Engelsdorp Gastelaars J, Bruin JP, Bogaert D, Rots NY, Sanders EAM, Trzciński K. Molecular surveillance of nasopharyngeal carriage of Streptococcus pneumoniae in children vaccinated with conjugated polysaccharide pneumococcal vaccines. Scientific Reports 2016, 6: 23809. PMID: 27046258, PMCID: PMC4820691, DOI: 10.1038/srep23809.Peer-Reviewed Original ResearchConceptsPneumococcal conjugate vaccinePolysaccharide pneumococcal vaccineVaccine-targeted serotypesStreptococcus pneumoniae carriageCross-sectional surveillanceVaccine serotypes 4Number of serotypesPneumococcal surveillancePneumococcal vaccinePneumoniae carriageUnvaccinated individualsConjugate vaccineNasopharyngeal carriagePneumococcal diseaseVaccine effectsNasopharyngeal samplesConventional diagnostic methodsSurveillance studyS. pneumoniaeStreptococcus pneumoniaeSerotype detectionMolecular surveillanceHidden circulationSerotypesDiagnostic methods
2013
Superiority of Trans-Oral over Trans-Nasal Sampling in Detecting Streptococcus pneumoniae Colonization in Adults
Trzciński K, Bogaert D, Wyllie A, Chu ML, van der Ende A, Bruin JP, van den Dobbelsteen G, Veenhoven RH, Sanders EA. Superiority of Trans-Oral over Trans-Nasal Sampling in Detecting Streptococcus pneumoniae Colonization in Adults. PLOS ONE 2013, 8: e60520. PMID: 23555985, PMCID: PMC3610877, DOI: 10.1371/journal.pone.0060520.Peer-Reviewed Original ResearchConceptsS. pneumoniaeLive pneumococciDiagnostic stepsTrans-nasal approachStreptococcus pneumoniae colonizationInitial diagnostic stepPneumoniae colonizationNasopharyngeal samplesPneumococcal colonizationNasopharyngeal colonizationStreptococcus pneumoniaeHuman nasopharynxPneumococciPneumoniaeCell harvestAdultsQPCRQPCR resultsMain reservoirMolecular methods