2024
Serological Profiling of Pneumococcal Proteins Reveals Unique Patterns of Acquisition, Maintenance, and Waning of Antibodies Throughout Life
He S, Voß F, Nicolaie M, Brummelman J, van de Garde M, Bijvank E, Poelen M, Wijmenga-Monsuur A, Wyllie A, Trzciński K, Van Beek J, Rots N, Hartog G, Hammerschmidt S, van C. Serological Profiling of Pneumococcal Proteins Reveals Unique Patterns of Acquisition, Maintenance, and Waning of Antibodies Throughout Life. The Journal Of Infectious Diseases 2024, jiae216. PMID: 38679601, DOI: 10.1093/infdis/jiae216.Peer-Reviewed Original ResearchIgG levelsPneumococcal proteinsAntibody responseLow IgG levelsSerum IgG levelsWaning of antibodiesIncreased IgG levelsAdults aged >Age-targeted interventionsProtein-specific antibody responsesPneumococcal carriageOlder adults aged >Streptococcus pneumoniaeSerological profileOlder infantsOlder ageOlder childrenOlder adultsAntibodiesAgeCarriageAdultsChildrenUnique pattern
2021
Delayed production of neutralizing antibodies correlates with fatal COVID-19
Lucas C, Klein J, Sundaram ME, Liu F, Wong P, Silva J, Mao T, Oh JE, Mohanty S, Huang J, Tokuyama M, Lu P, Venkataraman A, Park A, Israelow B, Vogels CBF, Muenker MC, Chang CH, Casanovas-Massana A, Moore AJ, Zell J, Fournier JB, Wyllie A, Campbell M, Lee A, Chun H, Grubaugh N, Schulz W, Farhadian S, Dela Cruz C, Ring A, Shaw A, Wisnewski A, Yildirim I, Ko A, Omer S, Iwasaki A. Delayed production of neutralizing antibodies correlates with fatal COVID-19. Nature Medicine 2021, 27: 1178-1186. PMID: 33953384, PMCID: PMC8785364, DOI: 10.1038/s41591-021-01355-0.Peer-Reviewed Original ResearchConceptsDeceased patientsAntibody levelsAntibody responseDisease severityAnti-S IgG levelsCOVID-19 disease outcomesFatal COVID-19Impaired viral controlWorse clinical progressionWorse disease severitySevere COVID-19Length of hospitalizationImmunoglobulin G levelsHumoral immune responseCoronavirus disease 2019COVID-19 mortalityCOVID-19Domain (RBD) IgGSeroconversion kineticsDisease courseIgG levelsClinical parametersClinical progressionHumoral responseDisease onset