2024
Serological Profiling of Pneumococcal Proteins Reveals Unique Patterns of Acquisition, Maintenance, and Waning of Antibodies Throughout Life
He S, Voß F, Nicolaie M, Brummelman J, van de Garde M, Bijvank E, Poelen M, Wijmenga-Monsuur A, Wyllie A, Trzciński K, Van Beek J, Rots N, Hartog G, Hammerschmidt S, van C. Serological Profiling of Pneumococcal Proteins Reveals Unique Patterns of Acquisition, Maintenance, and Waning of Antibodies Throughout Life. The Journal Of Infectious Diseases 2024, jiae216. PMID: 38679601, DOI: 10.1093/infdis/jiae216.Peer-Reviewed Original ResearchIgG levelsPneumococcal proteinsAntibody responseLow IgG levelsSerum IgG levelsWaning of antibodiesIncreased IgG levelsAdults aged >Age-targeted interventionsProtein-specific antibody responsesPneumococcal carriageOlder adults aged >Streptococcus pneumoniaeSerological profileOlder infantsOlder ageOlder childrenOlder adultsAntibodiesAgeCarriageAdultsChildrenUnique pattern
2022
Pneumococcal genetic variability in age-dependent bacterial carriage
Kremer P, Ferwerda B, Bootsma HJ, Rots NY, Wijmenga-Monsuur AJ, Sanders E, Trzciński K, Wyllie AL, Turner P, van der Ende A, Brouwer MC, Bentley SD, van de Beek D, Lees JA. Pneumococcal genetic variability in age-dependent bacterial carriage. ELife 2022, 11: e69244. PMID: 35881438, PMCID: PMC9395192, DOI: 10.7554/elife.69244.Peer-Reviewed Original ResearchConceptsSecond cohortImproved vaccine formulationsFirst cohortFuture vaccination strategiesSingle nucleotide polymorphismsHost immune factorsAge-specific differencesPneumococcal carriageImmune factorsVaccination strategiesBacterial carriageCarriage studiesVaccine formulationsCohortGenetic factorsAdult hostsSerotypesHost ageAdultsCarriageChildrenGenetic backgroundWeak evidenceInfantsPopulation
2021
1321. Acquisition and Transmission of Streptococcus pneumoniae in Individuals Over the Age of 60 Years Residing in New Haven, CT, USA
Wyllie A, Mbodj S, Yolda-Carr D, Thammavongsa D, Waghela P, Nakahata M, Vega N, York A, Allicock O, Alexander-Parrish R, Arguedas A, Gessner B, Weinberger D, Hislop M. 1321. Acquisition and Transmission of Streptococcus pneumoniae in Individuals Over the Age of 60 Years Residing in New Haven, CT, USA. Open Forum Infectious Diseases 2021, 8: 749-749. PMCID: PMC8689704, DOI: 10.1093/ofid/ofab466.1513.Peer-Reviewed Original ResearchPneumococcal carriageSaliva samplesOlder adultsPreventative public health measuresPneumococcal conjugate vaccineNew Haven areaPublic health measuresPneumococcal acquisitionPneumococcal diseaseConjugate vaccinePneumococcal transmissionStudy enrollmentMedical historyImportant burdenDemonstrate evidenceStreptococcus pneumoniaeHealth measuresMultiple timepointsTime pointsWeeksAdultsCOVID-19 pandemicAgeHigh ratePneumococci
2020
Serotype Patterns of Pneumococcal Disease in Adults Are Correlated With Carriage Patterns in Older Children
Wyllie AL, Warren JL, Regev-Yochay G, Givon-Lavi N, Dagan R, Weinberger DM. Serotype Patterns of Pneumococcal Disease in Adults Are Correlated With Carriage Patterns in Older Children. Clinical Infectious Diseases 2020, 72: e768-e775. PMID: 32989457, PMCID: PMC8315131, DOI: 10.1093/cid/ciaa1480.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseSerotype-specific invasive pneumococcal diseaseDisease patternsOlder childrenPneumococcal diseasePneumococcal carriageCarriage prevalenceSerotype patternsCause of IPDIPD dataSerotype-specific carriage prevalenceAge groupingsDifferent age groupsComorbidity statusDisease burdenVaccination strategiesAge-related patternsCarriage dataCarriage patternsDifferent age categoriesAge groupsSpecific serotypesYoung adultsAdultsAge categoriesUpper respiratory tract colonization with Streptococcus pneumoniae in adults
Arguedas A, Trzciński K, O’Brien K, Ferreira DM, Wyllie AL, Weinberger D, Danon L, Pelton SI, Azzari C, Hammitt LL, Sá-Leão R, Brandileone MC, Saha S, Suaya J, Isturiz R, Jodar L, Gessner BD. Upper respiratory tract colonization with Streptococcus pneumoniae in adults. Expert Review Of Vaccines 2020, 19: 353-366. PMID: 32237926, DOI: 10.1080/14760584.2020.1750378.Peer-Reviewed Original ResearchConceptsPediatric approachPneumococcal colonizationPneumococcal detectionRespiratory sitesUpper respiratory tract colonizationAdult respiratory tractRespiratory tract colonizationHigh disease burdenPneumococcal carriage studiesRespiratory carriageNasal washesPeer-reviewed journalsRespiratory colonizationCarriage prevalencePneumococcal transmissionTract colonizationDisease burdenRespiratory tractCarriage studiesCurrent evidenceStreptococcus pneumoniaeMolecular diagnostic methodsRoutine cultureAdultsRecent evidence
2013
Superiority of Trans-Oral over Trans-Nasal Sampling in Detecting Streptococcus pneumoniae Colonization in Adults
Trzciński K, Bogaert D, Wyllie A, Chu ML, van der Ende A, Bruin JP, van den Dobbelsteen G, Veenhoven RH, Sanders EA. Superiority of Trans-Oral over Trans-Nasal Sampling in Detecting Streptococcus pneumoniae Colonization in Adults. PLOS ONE 2013, 8: e60520. PMID: 23555985, PMCID: PMC3610877, DOI: 10.1371/journal.pone.0060520.Peer-Reviewed Original ResearchConceptsS. pneumoniaeLive pneumococciDiagnostic stepsTrans-nasal approachStreptococcus pneumoniae colonizationInitial diagnostic stepPneumoniae colonizationNasopharyngeal samplesPneumococcal colonizationNasopharyngeal colonizationStreptococcus pneumoniaeHuman nasopharynxPneumococciPneumoniaeCell harvestAdultsQPCRQPCR resultsMain reservoirMolecular methods