2017
A translational approach for NMDA receptor profiling as a vulnerability biomarker for depression and schizophrenia
Gunduz‐Bruce H, Kenney J, Changlani S, Peixoto A, Gueorguieva R, Leone C, Stachenfeld N. A translational approach for NMDA receptor profiling as a vulnerability biomarker for depression and schizophrenia. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2017, 102: 587-597. PMID: 28294453, DOI: 10.1113/ep086212.Peer-Reviewed Original ResearchConceptsSubgroup of patientsHealthy control subjectsNMDA receptorsControl subjectsDepressed patientsAVP releaseAnimal studiesSchizophrenic subjectsTranslational approachVivo evidenceRecent clinical trialsNMDA receptor functionPlasma arginine vasopressin concentrationNMDA receptor activityHypertonic saline infusionNMDA antagonist ketamineArginine vasopressin concentrationHypertonic salineInverse associationClinical trialsHealthy controlsSaline infusionGlutamate signalingSchizophrenic patientsVasopressin concentration
2007
CSF sub-compartments in relation to plasma osmolality in healthy controls and in patients with first episode schizophrenia
Gunduz-Bruce H, Narr KL, Gueorguieva R, Toga AW, Szeszko PR, Ashtari M, Robinson DG, Sevy S, Kane JM, Bilder RM. CSF sub-compartments in relation to plasma osmolality in healthy controls and in patients with first episode schizophrenia. Psychiatry Research 2007, 155: 57-66. PMID: 17398079, PMCID: PMC3299193, DOI: 10.1016/j.pscychresns.2006.12.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingCerebral VentriclesDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleOsmolar ConcentrationPlasmaSchizophreniaConceptsFirst-episode schizophreniaHealthy controlsEpisode schizophreniaMagnetic resonance imagingVentricle sizePlasma osmolalityHealthy control groupSignificant group effectVentricular morphologyCSF concentrationsLateral ventricleHealthy volunteersBlood samplesPatientsControl groupHigher plasmaWhite matterResonance imagingSuperior hornBrain morphologyTesla scannerSchizophreniaSignificant correlationOsmolalityPreliminary evidence