2015
Acute alcohol consumption elevates serum bilirubin: An endogenous antioxidant
O’Malley S, Gueorguieva R, Wu R, Jatlow PI. Acute alcohol consumption elevates serum bilirubin: An endogenous antioxidant. Drug And Alcohol Dependence 2015, 149: 87-92. PMID: 25707709, PMCID: PMC4540054, DOI: 10.1016/j.drugalcdep.2015.01.023.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlanine TransaminaseAlcohol DrinkingAntioxidantsAspartate AminotransferasesBilirubinCentral Nervous System DepressantsEthanolFemaleGlucuronosyltransferaseHumansMaleSmokingYoung AdultConceptsSerum bilirubinAlcohol consumptionBilirubin concentrationReduced riskTotal serum bilirubin concentrationModerate alcohol consumptionFavorable effectSerum bilirubin concentrationIndirect bilirubin concentrationsFuture longitudinal studiesMixed effects regression modelsCause mortalityBlood concentrationsCardiovascular diseaseAlcohol abstinenceHealthy individualsEndogenous antioxidantsBilirubinRandom orderNext morningEffects regression modelsLongitudinal studyNonsmokersAntioxidant propertiesBaseline
2007
Absence of Significant Interactive Effects of High‐Dose d‐Cycloserine and Ethanol in Healthy Human Subjects: Preliminary Insights Into Ethanol Actions at the GlycineB Site of NMDA Glutamate Receptors
Trevisan L, Petrakis IL, Pittman B, Gueorguieva R, D’Souza D, Perry E, Limoncelli D, Krystal JH. Absence of Significant Interactive Effects of High‐Dose d‐Cycloserine and Ethanol in Healthy Human Subjects: Preliminary Insights Into Ethanol Actions at the GlycineB Site of NMDA Glutamate Receptors. Alcohol Clinical And Experimental Research 2007, 32: 36-42. PMID: 18028532, DOI: 10.1111/j.1530-0277.2007.00543.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholic IntoxicationBreath TestsCentral Nervous System DepressantsCognitionCycloserineDose-Response Relationship, DrugDrug InteractionsEthanolFemaleGlycineHumansMaleMental RecallReceptors, N-Methyl-D-AspartateSpeechConceptsCo-agonist siteHealthy human subjectsEthanol administrationD-cycloserineHigh-dose d-cycloserineAlcohol levelsReceptor functionPlacebo 4 hoursDouble-blind conditionsNMDA receptor functionNMDA glutamate receptorsMild sedative effectDoses of ethanolGlutamate receptor functionBreath alcohol levelsHuman subjectsVerbal fluencyGlycineB siteGroups of subjectsEthanol antagonismCombination of ethanolSedative effectsNMDA receptorsClinical significanceGlutamate receptorsMultidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA‐Ar
Pittman B, Gueorguieva R, Krupitsky E, Rudenko AA, Flannery BA, Krystal JH. Multidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA‐Ar. Alcohol Clinical And Experimental Research 2007, 31: 612-618. PMID: 17374040, DOI: 10.1111/j.1530-0277.2007.00345.x.Peer-Reviewed Original ResearchConceptsAlcohol withdrawal syndromeCIWA-ArClinical Institute Withdrawal Assessment-AlcoholSymptom ChecklistCIWA-Ar scoresFirst study dayInpatient treatment unitAlcohol-dependent male inpatientsObserver-rated scalesAlcohol withdrawalWithdrawal syndromeTension/anxietyMale inpatientsIndependent factorsStudy daysClinical relevanceSelf-rating scaleAlcohol cravingObserver-rated measuresDiscriminative valueSelf-rated measuresInitial weeksAutonomic arousalFace validityResearch settings
2006
Enhanced Sensitivity to the Euphoric Effects of Alcohol in Schizophrenia
D'Souza DC, Gil RB, Madonick S, Perry EB, Forselius-Bielen K, Braley G, Donahue L, Tellioglu T, Zimolo Z, Gueorguieva R, Krystal JH. Enhanced Sensitivity to the Euphoric Effects of Alcohol in Schizophrenia. Neuropsychopharmacology 2006, 31: 2767-2775. PMID: 16985503, DOI: 10.1038/sj.npp.1301207.Peer-Reviewed Original ResearchConceptsEffects of alcoholHealthy subjectsBlood alcohol levelsPositive psychotic symptomsSmall transient increaseSelf-medication hypothesisPerceptual alterationsAlcohol administrationMotor functionAlcohol dosesElevated riskPsychotic symptomsLifetime exposureSchizophrenia patientsSchizophrenia symptomsEuphoric effectsNegative symptomsAlcohol levelsAlcohol useStimulatory effectSubjective effectsTransient increaseSchizophreniaStimulatory responseAlcohol responsesGelatin “Shots” as a New Method for Alcohol Administration in a Laboratory Setting
Ralevski E, Gueorguieva R, Limoncelli DD, Husain R, Jane J, Petrakis I. Gelatin “Shots” as a New Method for Alcohol Administration in a Laboratory Setting. Alcohol Clinical And Experimental Research 2006, 30: 473-479. PMID: 16499488, DOI: 10.1111/j.1530-0277.2006.00064.x.Peer-Reviewed Original ResearchAffectAlcoholic IntoxicationBeveragesBreath TestsCentral Nervous System DepressantsCitrus sinensisDrug CarriersEthanolGelatinHumansPlacebosResearch Design