2000
A Randomized Controlled Trial of Auricular Acupuncture for Cocaine Dependence
Avants S, Margolin A, Holford T, Kosten T. A Randomized Controlled Trial of Auricular Acupuncture for Cocaine Dependence. JAMA Internal Medicine 2000, 160: 2305-2312. PMID: 10927727, DOI: 10.1001/archinte.160.15.2305.Peer-Reviewed Original ResearchConceptsAuricular acupunctureCocaine dependenceCocaine addictionOpiate dependent populationUrine toxicology screenMethadone-maintained patientsCocaine-negative urine samplesDrug treatment facilitiesPrimary outcomeControlled TrialsToxicology screenTreatment modalitiesTreat sampleEffective treatmentUrine dataAcupunctureTreatment sessionsCocaine useRelaxation controlUrine samplesPatientsLongitudinal analysisTreatmentFurther investigationControl condition
1998
Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial.
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. Journal Of Neurosurgery 1998, 89: 699-706. PMID: 9817404, DOI: 10.3171/jns.1998.89.5.0699.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryHours of injuryCord injuryFunctional recoveryRandomized double-blind clinical trialMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-CareSeizures with Fever After Unprovoked Seizures: An Analysis in Children Followed from the Time of a First Febrile Seizure
Berg A, Darefsky A, Holford T, Shinnar S. Seizures with Fever After Unprovoked Seizures: An Analysis in Children Followed from the Time of a First Febrile Seizure. Epilepsia 1998, 39: 77-80. PMID: 9578016, DOI: 10.1111/j.1528-1157.1998.tb01277.x.Peer-Reviewed Original ResearchConceptsFirst febrile seizureFebrile seizuresUnprovoked seizuresFurther seizuresFirst unprovoked seizureRecurrent febrile seizuresCox regression modelBenign febrile seizuresInfluence recurrenceTime-dependent covariatesProspective cohortSecond seizureTreatment decisionsFeverSeizuresSubstantial riskRate ratioYoung childrenChildrenOnsetRegression modelsSmall proportionRiskPredictorsRecurrence
1996
Second solid tumors in patients with Hodgkin's disease cured after radiation or chemotherapy plus adjuvant low-dose radiation.
Salloum E, Doria R, Schubert W, Zelterman D, Holford T, Roberts K, Farber L, Kiehl R, Cardinale J, Cooper D. Second solid tumors in patients with Hodgkin's disease cured after radiation or chemotherapy plus adjuvant low-dose radiation. Journal Of Clinical Oncology 1996, 14: 2435-43. PMID: 8823321, DOI: 10.1200/jco.1996.14.9.2435.Peer-Reviewed Original ResearchConceptsOverall relative riskHodgkin's diseaseRT groupRelative riskSolid tumorsCMT groupRadiation therapyLung cancerBreast cancerEarly-stage Hodgkin's diseaseFull-dose radiation therapyInvolved-field radiationSecond solid tumorsConnecticut Tumor RegistryEarly-stage diseaseLong-term survivorsDifferent therapeutic approachesCases of lungLow-dose radiationSignificant increaseActuarial incidenceMedian followSalvage chemotherapyAdvanced diseaseDurable remissions
1995
Second solid malignancies after combined modality therapy for Hodgkin's disease.
Doria R, Holford T, Farber L, Prosnitz L, Cooper D. Second solid malignancies after combined modality therapy for Hodgkin's disease. Journal Of Clinical Oncology 1995, 13: 2016-22. PMID: 7636543, DOI: 10.1200/jco.1995.13.8.2016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyFemaleFollow-Up StudiesHodgkin DiseaseHumansIncidenceLymphoma, Non-HodgkinMaleMiddle AgedNeoplasms, Second PrimaryPoisson DistributionRadiation InjuriesRadiotherapyRadiotherapy DosageRecurrenceRemission InductionRisk FactorsConceptsSecond solid malignanciesActuarial incidenceRelative riskHodgkin's diseaseSolid tumorsGroup BRecurrent diseaseSolid malignanciesGroup AUntreated advanced Hodgkin's diseaseAdvanced Hodgkin's diseaseOverall relative riskLow-dose radiationSignificant increaseAdvanced diseaseUntreated patientsModality therapyHodgkin's lymphomaPatientsDiseaseCarcinogenic effectsChemotherapyLymphomaMalignancyCMT
1993
Analysis as‐randomized and the problem of non‐adherence: An example from the veterans affairs randomized trial of coronary artery bypass surgery
Peduzzi P, Wittes J, Detre K, Holford T. Analysis as‐randomized and the problem of non‐adherence: An example from the veterans affairs randomized trial of coronary artery bypass surgery. Statistics In Medicine 1993, 12: 1185-1195. PMID: 8210821, DOI: 10.1002/sim.4780121302.Peer-Reviewed Original ResearchConceptsCoronary artery bypass surgeryArtery bypass surgeryTreatment groupsAlternative treatment groupBypass surgeryTreatment changesVeterans Administration Cooperative StudyTime of randomizationRandomized clinical trialsTreat analysisClinical trialsOutcome eventsRandom treatment assignmentCooperative StudyVeterans AffairsTreatment assignmentTherapySurgeryTrialsGroupPatients
1992
Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Collins W, Holford T, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1992, 76: 23-31. PMID: 1727165, DOI: 10.3171/jns.1992.76.1.0023.Peer-Reviewed Original ResearchConceptsHours of injuryAcute spinal cord injurySpinal cord injuryNaloxone treatmentCord injuryMotor functionSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyAcute spinal cord traumaPreservation of motorTrial of methylprednisoloneSpinal cord traumaTotal sensoryPlacebo groupCord traumaNeurological functionStudy doseEmergency roomMethylprednisoloneInjury studiesMortality ratePatientsSensory function
1988
Diabetic nephropathy: Pregnancy performance and fetomaternal outcome
Reece E, Coustan D, Hayslett J, Holford T, Coulehan J, O'Connor T, Hobbins J. Diabetic nephropathy: Pregnancy performance and fetomaternal outcome. American Journal Of Obstetrics And Gynecology 1988, 159: 56-66. PMID: 3394754, DOI: 10.1016/0002-9378(88)90494-2.Peer-Reviewed Original ResearchConceptsGestational ageDiabetic nephropathyRenal diseaseMaternal blood pressureUnderlying renal diseaseMean gestational ageRespiratory distress syndromeInsulin-dependent diabetesPerinatal survival rateApparent adverse effectsFetomaternal outcomeNeonatal complicationsPregnancy performanceFetal outcomesNeonatal outcomesCreatinine clearanceBlood pressureDistress syndromeEarly pregnancyNeonatal careNephrotic syndromeFetal surveillanceBirth weightMaternal healthNatural course
1982
CLINICAL CHARACTERISTICS AND CIGARETTE SMOKING IN RELATION TO PROGNOSIS OF ANGINA PECTORIS IN FRAMINGHAM
HUBERT H, HOLFORD T, KANNEL W. CLINICAL CHARACTERISTICS AND CIGARETTE SMOKING IN RELATION TO PROGNOSIS OF ANGINA PECTORIS IN FRAMINGHAM. American Journal Of Epidemiology 1982, 115: 231-242. PMID: 7058782, DOI: 10.1093/oxfordjournals.aje.a113295.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAngina PectorisBlood PressureCoronary DiseaseFollow-Up StudiesHumansMaleMassachusettsMiddle AgedPrognosisSmokingTime FactorsConceptsAngina pectorisBlood pressureAngina onsetElectrocardiographic findingsUncomplicated angina pectorisCoronary risk factorsFuture coronary eventsElevated blood pressurePowerful independent predictorCigarette smoking habitsLong-term prognosisSystolic blood pressureLong-term followYears of ageLack of associationCoronary eventsCoronary riskBaseline characteristicsSymptom onsetYounger patientsIndependent predictorsPrognostic advantageSmoking habitsAbnormal electrocardiogramCigarette smoking