2023
Patterns of Birth Cohort‒Specific Smoking Histories in Brazil
Tam J, Jaffri M, Mok Y, Jeon J, Szklo A, Souza M, Holford T, Levy D, Cao P, Sánchez-Romero L, Meza R. Patterns of Birth Cohort‒Specific Smoking Histories in Brazil. American Journal Of Preventive Medicine 2023, 64: s63-s71. PMID: 36775755, PMCID: PMC10240503, DOI: 10.1016/j.amepre.2022.12.002.Peer-Reviewed Original ResearchConceptsMean cigarettesBirth cohortSmoker prevalenceSmoking patternsLong-term health outcomesGlobal Adult Tobacco SurveyAdult Tobacco SurveyNational Health SurveyStronger tobacco control policiesTobacco control policiesSmoking historySmoking cessationPublic health decisionsSmoking prevalenceRisk factorsChronic diseasesHealth SurveyTobacco useSmoking initiationHealth outcomesFemale cohortCohortTobacco SurveyTelephone interviewsSmoking parametersBirth Cohort‒Specific Smoking Patterns by Family Income in the U.S.
Jeon J, Cao P, Fleischer N, Levy D, Holford T, Meza R, Tam J. Birth Cohort‒Specific Smoking Patterns by Family Income in the U.S. American Journal Of Preventive Medicine 2023, 64: s32-s41. PMID: 36653231, PMCID: PMC11186479, DOI: 10.1016/j.amepre.2022.07.019.Peer-Reviewed Original ResearchConceptsFederal poverty levelBirth cohortSmoking patternsSmoking prevalenceFamily incomeRecent cohortsRecent birth cohortsHigh-income groupsCessation probabilitiesLower cessationPoverty levelCohortMore recent cohortsSmoking disparitiesPrevalenceIncome groupsIntervention strategiesCohort modelOlder cohortGreater declineLevel groupLow-income individualsCessationCohort differencesFuture studies
2019
CP*Trends: An Online Tool for Comparing Cohort and Period Trends Across Cancer Sites
Holford TR, Chen HS, Annett D, Krapcho M, Dorogaeva A, Feuer EJ. CP*Trends: An Online Tool for Comparing Cohort and Period Trends Across Cancer Sites. American Journal Of Epidemiology 2019, 188: 1361-1370. PMID: 30989187, PMCID: PMC6601534, DOI: 10.1093/aje/kwz089.Peer-Reviewed Original ResearchConceptsColorectal cancer incidenceCancer incidenceCancer sitesContribution of periodMale prostate cancerEnd Results (SEER) dataStudy of etiologyFemale lungCancer mortalityBronchial cancerProstate cancerCohortDisease controlRelevant exposuresIncidenceAge shiftLungCancerMortalityP scoreAgeResult dataPeriod trendsPeriodPercentage of deviance
2018
Smoking and Lung Cancer Mortality in the United States From 2015 to 2065: A Comparative Modeling Approach.
Jeon J, Holford TR, Levy DT, Feuer EJ, Cao P, Tam J, Clarke L, Clarke J, Kong CY, Meza R. Smoking and Lung Cancer Mortality in the United States From 2015 to 2065: A Comparative Modeling Approach. Annals Of Internal Medicine 2018, 169: 684-693. PMID: 30304504, PMCID: PMC6242740, DOI: 10.7326/m18-1250.Peer-Reviewed Original ResearchConceptsLung cancer mortalityTobacco control effortsCancer mortalityLung cancer ratesLung cancerCancer ratesLung cancer burdenLung cancer deathsLung cancer screeningSmoking-related diseasesU.S. populationNational Cancer InstituteLonger life expectancyCancer burdenSmoking patternsCancer deathCessation effortsCancer screeningTobacco useCancer InstituteSmokingAdditional preventionNatural historyMortalityCancer
2016
Comparison of Smoking History Patterns Among African American and White Cohorts in the United States Born 1890 to 1990.
Holford TR, Levy DT, Meza R. Comparison of Smoking History Patterns Among African American and White Cohorts in the United States Born 1890 to 1990. Nicotine & Tobacco Research 2016, 18 Suppl 1: s16-29. PMID: 26980861, PMCID: PMC5009449, DOI: 10.1093/ntr/ntv274.Peer-Reviewed Original ResearchConceptsNational Health Interview SurveySmoking-related diseasesSmoking historyHealth Interview SurveySurgeon General's ReportBirth cohortCessation probabilitiesSmoking intensityAfrican AmericansUS National Health Interview SurveyInterview SurveyNumber of cigarettesHigh smoking prevalenceLower cessation ratesCurrent smoking behaviorLife course exposuresAdverse health effectsLower cessationSmoking exposureCessation ratesSmoking prevalenceHigh prevalenceGeneral's ReportSmoking behaviorYounger age
2014
Proximity to Natural Gas Wells and Reported Health Status: Results of a Household Survey in Washington County, Pennsylvania
Rabinowitz PM, Slizovskiy IB, Lamers V, Trufan SJ, Holford TR, Dziura JD, Peduzzi PN, Kane MJ, Reif JS, Weiss TR, Stowe MH. Proximity to Natural Gas Wells and Reported Health Status: Results of a Household Survey in Washington County, Pennsylvania. Environmental Health Perspectives 2014, 123: 21-26. PMID: 25204871, PMCID: PMC4286272, DOI: 10.1289/ehp.1307732.Peer-Reviewed Original ResearchConceptsHealth symptomsUpper respiratory symptomsPublic health impactRespiratory symptomsNeurological symptomsSymptom SurveyRespiratory conditionsSkin conditionsHypothesis generatingHealth statusSymptomsFurther studiesGastrointestinal conditionsHealth impactsHousehold educationPrevalenceWashington CountyHousehold proximityPersonsSmokingWater exposureHousehold surveyWork typePatterns of Birth Cohort–Specific Smoking Histories, 1965–2009
Holford TR, Levy DT, McKay LA, Clarke L, Racine B, Meza R, Land S, Jeon J, Feuer EJ. Patterns of Birth Cohort–Specific Smoking Histories, 1965–2009. American Journal Of Preventive Medicine 2014, 46: e31-e37. PMID: 24439359, PMCID: PMC3951759, DOI: 10.1016/j.amepre.2013.10.022.Peer-Reviewed Original ResearchConceptsSmoking historyBirth cohortU.S. National Health Interview SurveyNational Health Interview SurveySmoking-related mortalityHealth Interview SurveyTobacco control interventionsCurrent smoking behaviorAge-specific distributionSmoking statusSmoking patternsSmoking intensitySurvival differencesSmoking behaviorCohortControl interventionsDifferent birth cohortsDate of surveyInterview SurveyIntervention strategiesCohort modelSmokersAgePrevalenceSlow declineTobacco Control and the Reduction in Smoking-Related Premature Deaths in the United States, 1964-2012
Holford TR, Meza R, Warner KE, Meernik C, Jeon J, Moolgavkar SH, Levy DT. Tobacco Control and the Reduction in Smoking-Related Premature Deaths in the United States, 1964-2012. JAMA 2014, 311: 164-171. PMID: 24399555, PMCID: PMC4056770, DOI: 10.1001/jama.2013.285112.Peer-Reviewed Original ResearchConceptsEffect of smokingAge 40 yearsSmoking-related mortalityYears of lifeTobacco controlPremature deathSmoking historySmoking-related premature deathsNational Health Interview SurveyCigarette smoking exposureSmoking-related deathsCigarette smoking historyFirst Surgeon General's reportLife expectancyMortality rate ratiosNational mortality ratesUS adult populationHealth Interview SurveyOverall health outcomesSurgeon General's ReportPublic health achievementsSmoking exposurePrimary outcomeSmoking statusCigarette smoking
2012
Chapter 12: Yale Lung Cancer Model
Holford TR, Ebisu K, McKay L, Oh C, Zheng T. Chapter 12: Yale Lung Cancer Model. Risk Analysis 2012, 32: s151-s165. PMID: 22882886, PMCID: PMC3662537, DOI: 10.1111/j.1539-6924.2011.01754.x.Peer-Reviewed Original ResearchConceptsLung cancer deathsCarcinogenesis modelCancer deathLung cancer incidenceLung cancer modelTwo-stage clonal expansion modelCigarette smokingCancer incidenceCancer modelTobacco controlClonal expansion modelPopulation ratesCohort modelSmokingDeathHarmful effectsPopulation dataTemporal trendsMortalityObserved numberIncidenceControlChapter 4: Development of the Counterfactual Smoking Histories Used to Assess the Effects of Tobacco Control
Holford TR, Clark L. Chapter 4: Development of the Counterfactual Smoking Histories Used to Assess the Effects of Tobacco Control. Risk Analysis 2012, 32: s39-s50. PMID: 22882891, PMCID: PMC3490210, DOI: 10.1111/j.1539-6924.2011.01759.x.Peer-Reviewed Original ResearchConceptsTobacco controlNational Health Interview SurveyLung cancer mortalityNumber of cigarettesLung cancer modelHealth Interview SurveySurveillance Modeling NetworkSurgeon General's ReportSmoking historyCessation ratesCigarette smokingCancer mortalityCancer modelCancer interventionInterview SurveySmokingPublic healthCigarettesReportControl programsGeneral's ReportControlMortalityWomenImpact of Reduced Tobacco Smoking on Lung Cancer Mortality in the United States During 1975–2000
Moolgavkar SH, Holford TR, Levy DT, Kong CY, Foy M, Clarke L, Jeon J, Hazelton WD, Meza R, Schultz F, McCarthy W, Boer R, Gorlova O, Gazelle GS, Kimmel M, McMahon PM, de Koning HJ, Feuer EJ. Impact of Reduced Tobacco Smoking on Lung Cancer Mortality in the United States During 1975–2000. Journal Of The National Cancer Institute 2012, 104: 541-548. PMID: 22423009, PMCID: PMC3317881, DOI: 10.1093/jnci/djs136.Peer-Reviewed Original ResearchConceptsLung cancer deathsLung cancer mortalityCancer deathSmoking behaviorCancer mortalityMajor public health problemTobacco controlPublic health problemTobacco control strategiesNumber of deathsSmoking historyTobacco smokingLung cancerGroups of investigatorsBirth cohortHealth problemsFirst reportSmokingMortalityDeathUnited StatesWomenMenCohortCancer
2007
Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients
Ruaño G, Goethe J, Caley C, Woolley S, Holford T, Kocherla M, Windemuth A, Leon J. Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients. Molecular Psychiatry 2007, 12: 474-482. PMID: 17199131, DOI: 10.1038/sj.mp.4001944.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnalysis of VarianceAntipsychotic AgentsApolipoproteinsAppetite RegulationAryldialkylphosphataseBenzodiazepinesCross-Sectional StudiesFemaleGenomicsHumansLipid MetabolismMaleMental DisordersMiddle AgedOlanzapinePolymorphism, Single NucleotideReceptors, Cell SurfaceReceptors, LeptinReceptors, Neuropeptide YRisperidoneScavenger Receptors, Class BWeight GainConceptsSingle nucleotide polymorphismsPhysiogenomic analysisNeuropeptide Y receptor Y5Receptor single nucleotide polymorphismsScavenger receptor class BRisperidone-treated patientsSide effect profileReceptor class BDrug-specific mechanismsSimilar side effectsGenetic associationAtypical antipsychoticsEffect profileAppetite peptidesApolipoprotein ELeptin receptorParaoxonase 1Side effectsPatientsOlanzapineRisperidoneElevated weightApolipoprotein A4Lipid homeostasisMember 1
2003
Cigarette smoking and risk of non-Hodgkin lymphoma subtypes among women
Morton L, Holford T, Leaderer B, Boyle P, Zahm S, Zhang Y, Flynn S, Tallini G, Zhang B, Owens P, Zheng T. Cigarette smoking and risk of non-Hodgkin lymphoma subtypes among women. British Journal Of Cancer 2003, 89: 2087-2092. PMID: 14647142, PMCID: PMC2376853, DOI: 10.1038/sj.bjc.6601388.Peer-Reviewed Original ResearchConceptsNon-Hodgkin lymphomaCumulative lifetime exposureCurrent smoking statusCigarette smokingNHL subtypesFollicular lymphomaLifetime exposurePopulation-based case-control studyRisk of NHLEtiology of NHLNon-Hodgkin lymphoma subtypesDuration of smokingIntensity of smokingPrevious epidemiologic studiesCase-control studyPopulation-based controlsHistologic typeSmoking statusIncident casesTumor gradeLymphoma subtypesEpidemiologic studiesSmokingImmunologic typeLymphomaGlutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk
Zheng T, Holford T, Zahm S, Owens P, Boyle P, Zhang Y, Zhang B, Wise J, Stephenson L, Ali-Osman F. Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk. British Journal Of Cancer 2003, 88: 58-62. PMID: 12556960, PMCID: PMC2376773, DOI: 10.1038/sj.bjc.6600708.Peer-Reviewed Original ResearchConceptsBreast cancer riskGSTT1 null genotypeCancer riskAlcohol consumptionGST genotypesBreast cancerPostmenopausal womenGenetic polymorphismsIncident breast cancer patientsGlutathione S-transferase M1Breast cancer patientsT1 genetic polymorphismsCase-control studyGSTT1 genetic polymorphismsGlutathione S-transferaseS-transferase M1Cancer patientsEffect modificationGSTM1 genotypeHigh riskNew Haven CountyYounger ageCancerWomenRisk
2002
Use of hair colouring products and breast cancer risk a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Boyle P, Zhang B, Zhang Y, Zahm S. Use of hair colouring products and breast cancer risk a case–control study in Connecticut. European Journal Of Cancer 2002, 38: 1647-1652. PMID: 12142056, DOI: 10.1016/s0959-8049(02)00138-7.Peer-Reviewed Original ResearchRadiation exposure from diagnostic and therapeutic treatments and risk of breast cancer
Zheng T, Holford TR, Mayne ST, Luo J, Owens PH, Zhang B, Zhang W, Zhang Y. Radiation exposure from diagnostic and therapeutic treatments and risk of breast cancer. European Journal Of Cancer Prevention 2002, 11: 229-235. PMID: 12131656, DOI: 10.1097/00008469-200206000-00006.Peer-Reviewed Original ResearchConceptsBreast cancerTherapeutic radiation treatmentRadiation treatmentOdds ratioTherapeutic radiationSkin problemsBreast cancer risk factorsRadiation exposureCancer risk factorsBreast cancer riskCase-control studyDiagnostic X-ray exposurePostmenopausal womenRisk factorsCancer riskHigh riskYounger ageTherapeutic treatmentCancerDiagnostic X-raysPerson interviewsTreatmentX-ray exposureRiskStructured questionnaireA case-control study of occupation and breast-cancer risk in Connecticut.
Zheng T, Holford T, Taylor Mayne S, Luo J, Hansen Owens P, Hoar Zahm S, Zhang B, Zhang Y, Zhang W, Jiang Y, Boyle P. A case-control study of occupation and breast-cancer risk in Connecticut. Journal Of Cancer Epidemiology And Prevention 2002, 7: 3-11. PMID: 12369604, DOI: 10.1080/14766650252962621.Peer-Reviewed Original Research
2001
Restricted activity among community-living older persons: incidence, precipitants, and health care utilization.
Gill T, Desai M, Gahbauer E, Holford T, Williams C. Restricted activity among community-living older persons: incidence, precipitants, and health care utilization. Annals Of Internal Medicine 2001, 135: 313-21. PMID: 11529694, DOI: 10.7326/0003-4819-135-5-200109040-00007.Peer-Reviewed Original ResearchConceptsCommunity-living older personsHealth care utilizationCare utilizationRestricted activityOlder personsProspective cohort studyEmergency department visitsMonthly telephone interviewsPhysician office visitsLarge health planYears of ageHealth-related problemsCohort studyDepartment visitsHospital admissionOffice visitsFunctional statusMedical attentionHigh riskHealth plansTelephone interviewsMonthsConsecutive monthsEpisodesDisabilityLactation and breast cancer risk: a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Zhang Y, Zhang B, Boyle P, Zahm S. Lactation and breast cancer risk: a case–control study in Connecticut. British Journal Of Cancer 2001, 84: 1472-1476. PMID: 11384096, PMCID: PMC2363665, DOI: 10.1054/bjoc.2001.1793.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerCancer riskIncident breast cancer casesMajor risk factorCase-control studyBreast cancer casesRisk reductionMenopausal statusParous womenPostmenopausal womenInverse associationRisk factorsCancer casesStudy interviewersFurther stratificationFirst childWomenStructured questionnaireLifetime durationCancerRiskLactationChildrenBreastfeeding1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies
Laden F, Collman G, Iwamoto K, Alberg A, Berkowitz G, Freudenheim J, Hankinson S, Helzlsouer K, Holford T, Huang H, Moysich K, Tessari J, Wolff M, Zheng T, Hunter D. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies. Journal Of The National Cancer Institute 2001, 93: 768-775. PMID: 11353787, DOI: 10.1093/jnci/93.10.768.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerCancer riskRisk factorsEffect modificationOdds ratioBreast cancer risk factorsElevated breast cancer riskAssess effect modificationBody mass indexCancer risk factorsConfidence intervalsPooled odds ratioPotential risk factorsPlasma/serum concentrationsAssociation of levelsLarge U.S. studiesRandom-effects modelCase patientsMass indexMiddle tertileFifth quintilePooled analysisControl subjectsSerum concentrations