2016
Spatiotemporal calibration and resolution refinement of output from deterministic models
Gilani O, McKay LA, Gregoire TG, Guan Y, Leaderer BP, Holford TR. Spatiotemporal calibration and resolution refinement of output from deterministic models. Statistics In Medicine 2016, 35: 2422-2440. PMID: 26790617, DOI: 10.1002/sim.6867.Peer-Reviewed Original ResearchConceptsGrid-cell formatCurrent calibration techniquesSpatiotemporal calibrationModeling strategyCommunity Multiscale Air Quality (CMAQ) modelAir quality modelsMultiscale Air Quality modelCalibration techniqueObserved measurementsPixel sizeSpatial resolutionGrid dataMonitoring stationsQuality modelDeterministic modelRegular gridAmbient nitrogen dioxide concentrationsDaily estimatesMeasurementsProcess of interestGridNitrogen dioxide concentrationsProcessPixelsDioxide concentration
2015
Age‐Period‐Cohort approaches to back‐calculation of cancer incidence rate
Oh C, Holford TR. Age‐Period‐Cohort approaches to back‐calculation of cancer incidence rate. Statistics In Medicine 2015, 34: 1953-1964. PMID: 25715831, PMCID: PMC4980760, DOI: 10.1002/sim.6464.Peer-Reviewed Original ResearchConceptsCancer incidence ratesEstimates of incidenceHealth care planningCancer deathLung cancerCancer prevalenceCancer incidenceIncidence rateHealthy subjectsCare planningSurvival informationMortality statisticsCancerIncidence casesIncidenceAge periodDeathSubjectsCompartment modelCohortMortalityPrevalence
2002
Use of hair colouring products and breast cancer risk a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Boyle P, Zhang B, Zhang Y, Zahm S. Use of hair colouring products and breast cancer risk a case–control study in Connecticut. European Journal Of Cancer 2002, 38: 1647-1652. PMID: 12142056, DOI: 10.1016/s0959-8049(02)00138-7.Peer-Reviewed Original ResearchA case-control study of occupation and breast-cancer risk in Connecticut.
Zheng T, Holford T, Taylor Mayne S, Luo J, Hansen Owens P, Hoar Zahm S, Zhang B, Zhang Y, Zhang W, Jiang Y, Boyle P. A case-control study of occupation and breast-cancer risk in Connecticut. Journal Of Cancer Epidemiology And Prevention 2002, 7: 3-11. PMID: 12369604, DOI: 10.1080/14766650252962621.Peer-Reviewed Original Research
2001
Lactation and breast cancer risk: a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Zhang Y, Zhang B, Boyle P, Zahm S. Lactation and breast cancer risk: a case–control study in Connecticut. British Journal Of Cancer 2001, 84: 1472-1476. PMID: 11384096, PMCID: PMC2363665, DOI: 10.1054/bjoc.2001.1793.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerCancer riskIncident breast cancer casesMajor risk factorCase-control studyBreast cancer casesRisk reductionMenopausal statusParous womenPostmenopausal womenInverse associationRisk factorsCancer casesStudy interviewersFurther stratificationFirst childWomenStructured questionnaireLifetime durationCancerRiskLactationChildrenBreastfeeding
2000
Exposure to Electromagnetic Fields from Use of Electric Blankets and Other In-Home Electrical Appliances and Breast Cancer Risk
Zheng T, Holford T, Mayne S, Owens P, Zhang B, Boyle P, Carter D, Ward B, Zhang Y, Zahm S. Exposure to Electromagnetic Fields from Use of Electric Blankets and Other In-Home Electrical Appliances and Breast Cancer Risk. American Journal Of Epidemiology 2000, 151: 1103-1111. PMID: 10873135, DOI: 10.1093/oxfordjournals.aje.a010154.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskOdds ratioAge frequency-matched controlsIncident breast cancer patientsElectric blanketFrequency-matched controlsAdjusted odds ratioBreast cancer patientsEstrogen receptor statusFemale breast cancerCase-control studyDuration of useReceptor statusCancer patientsNever usersBreast cancerStudy interviewersRegular useLifetime useRiskStructured questionnaireExposureTotal
1999
DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer
Zheng T, Holford T, Mayne S, Ward B, Carter D, Ownes P, Dubrow R, Zahm S, Boyle P, Archibeque S, Tessari J. DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer. American Journal Of Epidemiology 1999, 150: 453-458. PMID: 10472944, DOI: 10.1093/oxfordjournals.aje.a010033.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast adipose tissueTissue levelsCancer riskAdipose tissueBenign breast disease controlsIncident breast cancer casesYale-New Haven HospitalBreast-related surgeryAdipose tissue levelsFemale breast cancerCase-control studyBreast cancer casesMean tissue levelsLogistic regression modelsRank sum testHighest quartileSurgical specimenDichlorodiphenyltrichloroethane (DDT) exposureOdds ratioBreast cancerCancer casesDisease controlSum testMean levelsIndoor, outdoor, and regional summer and winter concentrations of PM10, PM2.5, SO4(2)-, H+, NH4+, NO3-, NH3, and nitrous acid in homes with and without kerosene space heaters.
Leaderer B, Naeher L, Jankun T, Balenger K, Holford T, Toth C, Sullivan J, Wolfson J, Koutrakis P. Indoor, outdoor, and regional summer and winter concentrations of PM10, PM2.5, SO4(2)-, H+, NH4+, NO3-, NH3, and nitrous acid in homes with and without kerosene space heaters. Environmental Health Perspectives 1999, 107: 223-231. PMID: 10064553, PMCID: PMC1566377, DOI: 10.1289/ehp.99107223.Peer-Reviewed Original Research
1998
Re: Cigarette Smoking and Changes in the Histopathology of Lung Cancer
Holford T, Tongzhang Z, T. S. Re: Cigarette Smoking and Changes in the Histopathology of Lung Cancer. Journal Of The National Cancer Institute 1998, 90: 783-783. PMID: 9605651, DOI: 10.1093/jnci/90.10.783.Peer-Reviewed Original Research
1997
The increase of Hodgkin's disease incidence among young adults
Chen Y, Zheng T, Chou M, Boyle P, Holford T. The increase of Hodgkin's disease incidence among young adults. Cancer 1997, 79: 2209-2218. PMID: 9179069, DOI: 10.1002/(sici)1097-0142(19970601)79:11<2209::aid-cncr20>3.0.co;2-z.Peer-Reviewed Original ResearchConceptsHodgkin's disease incidenceHodgkin's diseaseRisk factorsVirus infectionYoung adultsEpstein-Barr virus infectionHuman immunodeficiency virus (HIV) infectionConnecticut Tumor RegistryImmunodeficiency virus infectionAnalytical epidemiologic studiesMajor risk factorIncidence rate changesAdults ages 20Young adults ages 20Tumor RegistryHistologic typeDisease incidenceCohort analysisEpidemiologic studiesAge 20Cohort patternsCohort phenomenonIncidenceDiseaseYoung femalesAre cancers of the salivary gland increasing? Experience from Connecticut, USA.
Zheng T, Holford T, Chen Y, Ward B, Liu W, Flannery J, Boyle P. Are cancers of the salivary gland increasing? Experience from Connecticut, USA. International Journal Of Epidemiology 1997, 26: 264-271. PMID: 9169160, DOI: 10.1093/ije/26.2.264.Peer-Reviewed Original ResearchConceptsSalivary glandsRelative riskBirth cohortRare squamous cell carcinomaEpstein-Barr virus infectionConnecticut Tumor Registry dataTime trendsComparable relative riskSquamous cell carcinomaTumor registry dataAge group 40Salivary gland cancerYears of ageOlder age groupsRecent birth cohortsObserved time trendsPrior cancerLower gumCell carcinomaGland cancerIncidence rateRisk factorsUnivariate analysisCancer sitesRegistry dataTime trend of female breast carcinoma In Situ by race and histology in Connecticut, U.S.A.
Zheng T, Holford T, Chen Y, Jones B, Flannery J, Boyle P. Time trend of female breast carcinoma In Situ by race and histology in Connecticut, U.S.A. European Journal Of Cancer 1997, 33: 96-100. PMID: 9071907, DOI: 10.1016/s0959-8049(96)00371-1.Peer-Reviewed Original ResearchConceptsAge-adjusted incidence ratesSitu breast cancerFemale breast carcinomaIncidence rateBreast cancerMammography screeningBreast carcinomaOverall age-adjusted incidence rateAge group 40 yearsAge groupsEarly-stage breast cancerAge-specific incidence ratesFemale breast cancer incidenceConnecticut Tumor RegistryBreast cancer incidenceStage breast cancerEfficacy of mammographyFemale breast cancerAge group 40Older age groupsTime trendsTumor RegistryIncident casesDuctal carcinomaCancer incidence
1996
Time trend and age‐period‐cohort effect on incidence of bladder cancer in Connecticut, 1935–1992
Zheng T, Holford T, Chen Y, Z. J, Mayne S, Liu W, Flannery J, Boyle P. Time trend and age‐period‐cohort effect on incidence of bladder cancer in Connecticut, 1935–1992. International Journal Of Cancer 1996, 68: 172-176. PMID: 8900423, DOI: 10.1002/(sici)1097-0215(19961009)68:2<172::aid-ijc5>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsUrinary bladder cancerMajor risk factorBladder cancerRisk factorsIncidence rateBirth-cohort patternSmoking-related cancersAnalytical epidemiologic studiesTime trendsTobacco smokingCigarette smokingLung cancerOccupational exposureEpidemiologic studiesCancerMarked increaseSmokingCohort effectsMalesRecent studiesCurrent studyFemalesIncidenceStudyConnecticutAsthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors.
Beckett W, Belanger K, Gent J, Holford T, Leaderer B. Asthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors. American Journal Of Respiratory And Critical Care Medicine 1996, 154: 894-899. PMID: 8887582, DOI: 10.1164/ajrccm.154.4.8887582.Peer-Reviewed Original ResearchConceptsRisk factorsPuerto Rican HispanicsSocioeconomic statusHispanic ethnicityHispanic mothersEnvironmental tobacco smoke exposureIndependent risk factorPhysician-diagnosed asthmaPrevalence of asthmaTobacco smoke exposureStrong risk factorAfrican American ethnicityEnvironmental risk factorsYr of ageLow socioeconomic statusStudy of asthmaNon-Hispanic whitesMo of ageActive smokingAsthmatic childrenSmoke exposureChildhood asthmaCigarette smokersMaternal ageMaternal historySex Differences in Survival After Myocardial Infarction in Older Adults: A Community‐Based Approach
Vaccarino V, Krumholz H, de Leon C, Holford T, Seeman T, Horwitz R, Berkman L. Sex Differences in Survival After Myocardial Infarction in Older Adults: A Community‐Based Approach. Journal Of The American Geriatrics Society 1996, 44: 1174-1182. PMID: 8855995, DOI: 10.1111/j.1532-5415.1996.tb01366.x.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMultivariable adjustmentClinical severityRelative riskPsychosocial factorsOlder individualsProspective cohort studyMain outcome measuresDemographic factorsSex differencesHospital complicationsCause mortalityLate mortalityClinical characteristicsCohort studyCT cohortHospital admissionOverall mortalityEarly mortalityElderly ProgramMean agePhysical functionFunctional statusMedical recordsOutcome measuresMalignant melanoma risk factors by anatomic site: A case‐control study and polychotomous logistic regression analysis
Chen Y, Dubrow R, Holford T, Zheng T, Barnhill R, Fine J, Berwick M. Malignant melanoma risk factors by anatomic site: A case‐control study and polychotomous logistic regression analysis. International Journal Of Cancer 1996, 67: 636-643. PMID: 8782651, DOI: 10.1002/(sici)1097-0215(19960904)67:5<636::aid-ijc8>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsMelanoma risk factorsCase-control studyRisk factorsAnatomic sitesSun exposurePopulation-based case-control studySun exposure-related factorsIntermittent sun exposureHistory of sunburnOnly risk factorPolychotomous logistic regression analysisInvasive melanoma casesNumber of neviLogistic regression analysisExposure-related factorsDevelopment of melanomaSex differencesPolychotomous logistic regressionHistologic subtypeMalignant melanomaClothing habitsPigmentary characteristicsMelanoma casesStudy subjectsLogistic regressionTime trend and age‐period‐cohort effect on incidence of thyroid cancer in Connecticut, 1935–1992
Zheng T, Holford T, Chen Y, Z. J, Flannery J, Liu W, Russi M, Boyle P. Time trend and age‐period‐cohort effect on incidence of thyroid cancer in Connecticut, 1935–1992. International Journal Of Cancer 1996, 67: 504-509. PMID: 8759608, DOI: 10.1002/(sici)1097-0215(19960807)67:4<504::aid-ijc7>3.0.co;2-w.Peer-Reviewed Original ResearchConceptsThyroid cancerChildhood conditionsOverall age-adjusted incidence rateStrong birth cohort effectAge-adjusted incidence ratesRadiation treatmentBirth cohort effectsBirth cohort analysisTime trendsCohort effectsObserved time trendsIncidence ratePapillary carcinomaCohort analysisCancerCohortIncidenceNeckMalesFemalesUnited StatesRecent studiesTreatmentCurrent studyCarcinomaMaternal Caffeine Consumption and Spontaneous Abortion: A Prospective Cohort Study
Dlugosz L, Belanger K, Hellenbrand K, Holford T, Leaderer B, Bracken M. Maternal Caffeine Consumption and Spontaneous Abortion: A Prospective Cohort Study. Epidemiology 1996, 7: 250-255. PMID: 8728437, DOI: 10.1097/00001648-199605000-00008.Peer-Reviewed Original ResearchConceptsSpontaneous abortionCaffeine consumptionYale-New Haven HospitalMaternal caffeine consumptionProspective cohort studyCohort studyEarly pregnancyPregnant womenOdds ratioSoda drinkingElevated riskCaffeine beveragesBeverage consumptionCaffeine beverage consumptionCigarette useFirst monthPregnancySixteenth weekObserved associationsAbortionCup of teaCaffeineTeaGestationHospitalA MODEL FOR THE EFFECT OF CIGARETTE SMOKING ON LUNG CANCER INCIDENCE IN CONNECTICUT
HOLFORD T, ZHANG Z, ZHENG T, MCKAY L. A MODEL FOR THE EFFECT OF CIGARETTE SMOKING ON LUNG CANCER INCIDENCE IN CONNECTICUT. Statistics In Medicine 1996, 15: 565-580. PMID: 8731001, DOI: 10.1002/(sici)1097-0258(19960330)15:6<565::aid-sim185>3.0.co;2-t.Peer-Reviewed Original ResearchConceptsLung cancer incidenceCancer incidenceIncidence rateLung cancer incidence ratesLung cancer incidence trendsEffect of smokingCancer incidence ratesCancer incidence trendsCohort studyCurrent smokersLevel of exposureMale smokersSmoking historySmoking subgroupsSmoking informationCigarette smokingMean durationSmoking prevalenceIncidence trendsSmokersSmokingPrevalenceCohort effectsAge distributionIncidenceContinuing increase in incidence of germ‐cell testis cancer in young adults: Experience from Connecticut, USA, 1935–1992
Zheng T, Holford T, Ma Z, Ward B, Flannery J, Boyle P. Continuing increase in incidence of germ‐cell testis cancer in young adults: Experience from Connecticut, USA, 1935–1992. International Journal Of Cancer 1996, 65: 723-729. PMID: 8631581, DOI: 10.1002/(sici)1097-0215(19960315)65:6<723::aid-ijc2>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsGerm cell testis cancerTestis cancerHistologic typeEpidemiologic studiesOverall age-adjusted incidence rateStrong birth cohort effectAge-adjusted incidence ratesEarly lifetime exposuresAnalytical epidemiologic studiesDescriptive epidemiologic studyAge group 20Birth cohort effectsObserved incidence patternsIncidence rateRisk factorsGroup 20Cancer registrationLifetime exposureIncidence patternsLarger sample sizeSeminomaCancerCohort modelingYoung adultsCohort