2014
Proximity to Natural Gas Wells and Reported Health Status: Results of a Household Survey in Washington County, Pennsylvania
Rabinowitz PM, Slizovskiy IB, Lamers V, Trufan SJ, Holford TR, Dziura JD, Peduzzi PN, Kane MJ, Reif JS, Weiss TR, Stowe MH. Proximity to Natural Gas Wells and Reported Health Status: Results of a Household Survey in Washington County, Pennsylvania. Environmental Health Perspectives 2014, 123: 21-26. PMID: 25204871, PMCID: PMC4286272, DOI: 10.1289/ehp.1307732.Peer-Reviewed Original ResearchConceptsHealth symptomsUpper respiratory symptomsPublic health impactRespiratory symptomsNeurological symptomsSymptom SurveyRespiratory conditionsSkin conditionsHypothesis generatingHealth statusSymptomsFurther studiesGastrointestinal conditionsHealth impactsHousehold educationPrevalenceWashington CountyHousehold proximityPersonsSmokingWater exposureHousehold surveyWork type
2007
Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients
Ruaño G, Goethe J, Caley C, Woolley S, Holford T, Kocherla M, Windemuth A, Leon J. Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients. Molecular Psychiatry 2007, 12: 474-482. PMID: 17199131, DOI: 10.1038/sj.mp.4001944.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnalysis of VarianceAntipsychotic AgentsApolipoproteinsAppetite RegulationAryldialkylphosphataseBenzodiazepinesCross-Sectional StudiesFemaleGenomicsHumansLipid MetabolismMaleMental DisordersMiddle AgedOlanzapinePolymorphism, Single NucleotideReceptors, Cell SurfaceReceptors, LeptinReceptors, Neuropeptide YRisperidoneScavenger Receptors, Class BWeight GainConceptsSingle nucleotide polymorphismsPhysiogenomic analysisNeuropeptide Y receptor Y5Receptor single nucleotide polymorphismsScavenger receptor class BRisperidone-treated patientsSide effect profileReceptor class BDrug-specific mechanismsSimilar side effectsGenetic associationAtypical antipsychoticsEffect profileAppetite peptidesApolipoprotein ELeptin receptorParaoxonase 1Side effectsPatientsOlanzapineRisperidoneElevated weightApolipoprotein A4Lipid homeostasisMember 1
2003
Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk
Zheng T, Holford T, Zahm S, Owens P, Boyle P, Zhang Y, Zhang B, Wise J, Stephenson L, Ali-Osman F. Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk. British Journal Of Cancer 2003, 88: 58-62. PMID: 12556960, PMCID: PMC2376773, DOI: 10.1038/sj.bjc.6600708.Peer-Reviewed Original ResearchConceptsBreast cancer riskGSTT1 null genotypeCancer riskAlcohol consumptionGST genotypesBreast cancerPostmenopausal womenGenetic polymorphismsIncident breast cancer patientsGlutathione S-transferase M1Breast cancer patientsT1 genetic polymorphismsCase-control studyGSTT1 genetic polymorphismsGlutathione S-transferaseS-transferase M1Cancer patientsEffect modificationGSTM1 genotypeHigh riskNew Haven CountyYounger ageCancerWomenRisk
2001
The Natural History of Periodontal Disease in Man. Risk Factors for Progression of Attachment Loss in Individuals Receiving No Oral Health Care
Neely A, Holford T, Löe H, Ånerud Å, Boysen H. The Natural History of Periodontal Disease in Man. Risk Factors for Progression of Attachment Loss in Individuals Receiving No Oral Health Care. Journal Of Periodontology 2001, 72: 1006-1015. PMID: 11525431, DOI: 10.1902/jop.2001.72.8.1006.Peer-Reviewed Original ResearchConceptsHistory of smokingAttachment lossPeriodontal attachment lossGingival indexCalculus indexPlaque indexRisk factorsPeriodontal diseaseNatural historyMean attachment lossOral health assessmentProfessional dental careOral health careFinal adjusted modelPotential risk factorsMesio-buccal surfaceThird molar teethBetel nut useAbsence of teethCaries indexDental careAttachment levelAdjusted modelNut useMolar teeth
1996
Asthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors.
Beckett W, Belanger K, Gent J, Holford T, Leaderer B. Asthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors. American Journal Of Respiratory And Critical Care Medicine 1996, 154: 894-899. PMID: 8887582, DOI: 10.1164/ajrccm.154.4.8887582.Peer-Reviewed Original ResearchConceptsRisk factorsPuerto Rican HispanicsSocioeconomic statusHispanic ethnicityHispanic mothersEnvironmental tobacco smoke exposureIndependent risk factorPhysician-diagnosed asthmaPrevalence of asthmaTobacco smoke exposureStrong risk factorAfrican American ethnicityEnvironmental risk factorsYr of ageLow socioeconomic statusStudy of asthmaNon-Hispanic whitesMo of ageActive smokingAsthmatic childrenSmoke exposureChildhood asthmaCigarette smokersMaternal ageMaternal historySecond solid tumors in patients with Hodgkin's disease cured after radiation or chemotherapy plus adjuvant low-dose radiation.
Salloum E, Doria R, Schubert W, Zelterman D, Holford T, Roberts K, Farber L, Kiehl R, Cardinale J, Cooper D. Second solid tumors in patients with Hodgkin's disease cured after radiation or chemotherapy plus adjuvant low-dose radiation. Journal Of Clinical Oncology 1996, 14: 2435-43. PMID: 8823321, DOI: 10.1200/jco.1996.14.9.2435.Peer-Reviewed Original ResearchConceptsOverall relative riskHodgkin's diseaseRT groupRelative riskSolid tumorsCMT groupRadiation therapyLung cancerBreast cancerEarly-stage Hodgkin's diseaseFull-dose radiation therapyInvolved-field radiationSecond solid tumorsConnecticut Tumor RegistryEarly-stage diseaseLong-term survivorsDifferent therapeutic approachesCases of lungLow-dose radiationSignificant increaseActuarial incidenceMedian followSalvage chemotherapyAdvanced diseaseDurable remissionsContinuing increase in incidence of germ‐cell testis cancer in young adults: Experience from Connecticut, USA, 1935–1992
Zheng T, Holford T, Ma Z, Ward B, Flannery J, Boyle P. Continuing increase in incidence of germ‐cell testis cancer in young adults: Experience from Connecticut, USA, 1935–1992. International Journal Of Cancer 1996, 65: 723-729. PMID: 8631581, DOI: 10.1002/(sici)1097-0215(19960315)65:6<723::aid-ijc2>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsGerm cell testis cancerTestis cancerHistologic typeEpidemiologic studiesOverall age-adjusted incidence rateStrong birth cohort effectAge-adjusted incidence ratesEarly lifetime exposuresAnalytical epidemiologic studiesDescriptive epidemiologic studyAge group 20Birth cohort effectsObserved incidence patternsIncidence rateRisk factorsGroup 20Cancer registrationLifetime exposureIncidence patternsLarger sample sizeSeminomaCancerCohort modelingYoung adultsCohort
1995
Second solid malignancies after combined modality therapy for Hodgkin's disease.
Doria R, Holford T, Farber L, Prosnitz L, Cooper D. Second solid malignancies after combined modality therapy for Hodgkin's disease. Journal Of Clinical Oncology 1995, 13: 2016-22. PMID: 7636543, DOI: 10.1200/jco.1995.13.8.2016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyFemaleFollow-Up StudiesHodgkin DiseaseHumansIncidenceLymphoma, Non-HodgkinMaleMiddle AgedNeoplasms, Second PrimaryPoisson DistributionRadiation InjuriesRadiotherapyRadiotherapy DosageRecurrenceRemission InductionRisk FactorsConceptsSecond solid malignanciesActuarial incidenceRelative riskHodgkin's diseaseSolid tumorsGroup BRecurrent diseaseSolid malignanciesGroup AUntreated advanced Hodgkin's diseaseAdvanced Hodgkin's diseaseOverall relative riskLow-dose radiationSignificant increaseAdvanced diseaseUntreated patientsModality therapyHodgkin's lymphomaPatientsDiseaseCarcinogenic effectsChemotherapyLymphomaMalignancyCMT
1992
A reversal in the long‐term increase in deaths attributable to malignant melanoma
Roush G, McKay L, Holford T. A reversal in the long‐term increase in deaths attributable to malignant melanoma. Cancer 1992, 69: 1714-1720. PMID: 1551056, DOI: 10.1002/1097-0142(19920401)69:7<1714::aid-cncr2820690712>3.0.co;2-z.Peer-Reviewed Original Research
1990
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDoseConception delay after oral contraceptive use: the effect of estrogen dose**Supported by grant HD 11357 and HD 16282 from the National Institutes for Child Health and Human Development and by grant DA 05484 from the National Institute for Drug Abuse, Bethesda, Maryland.
Bracken M, Hellenbrand K, Holford T. Conception delay after oral contraceptive use: the effect of estrogen dose**Supported by grant HD 11357 and HD 16282 from the National Institutes for Child Health and Human Development and by grant DA 05484 from the National Institute for Drug Abuse, Bethesda, Maryland. Fertility And Sterility 1990, 53: 21-27. PMID: 2295345, DOI: 10.1016/s0015-0282(16)53210-5.Peer-Reviewed Original ResearchConceptsOral contraceptive useContraceptive useFormer oral contraceptive usersConception delayFormer OC usersLower estrogen dosesOral contraceptive usersEffects of estrogenNational InstituteMethod of contraceptionEstrogen doseOC discontinuationEstrogen dosesOral contraceptionOC usersContraceptive usersChild healthProbability of conceptionHigh dosesDrug abuseMean timeDiscontinuationSignificant delaySignificant reductionEstrogen
1989
Age, period and cohort effects on the risk of major depression: results from five United States communities
Wickramaratne P, Weissman M, Leaf P, Holford T. Age, period and cohort effects on the risk of major depression: results from five United States communities. Journal Of Clinical Epidemiology 1989, 42: 333-343. PMID: 2723694, DOI: 10.1016/0895-4356(89)90038-3.Peer-Reviewed Original ResearchConceptsMajor depressionBirth cohortEpidemiologic Catchment Area studyYears of ageCatchment Area StudySuccessive birth cohortsLinear cohort effectCohort effectsPeriod of onsetPeriod effectsUnited States communitiesCohortDepressionAffected individualsCohort modelAgeWomenProbability sampleU.S. communitiesAPC modelMenOnset
1988
Diabetic nephropathy: Pregnancy performance and fetomaternal outcome
Reece E, Coustan D, Hayslett J, Holford T, Coulehan J, O'Connor T, Hobbins J. Diabetic nephropathy: Pregnancy performance and fetomaternal outcome. American Journal Of Obstetrics And Gynecology 1988, 159: 56-66. PMID: 3394754, DOI: 10.1016/0002-9378(88)90494-2.Peer-Reviewed Original ResearchConceptsGestational ageDiabetic nephropathyRenal diseaseMaternal blood pressureUnderlying renal diseaseMean gestational ageRespiratory distress syndromeInsulin-dependent diabetesPerinatal survival rateApparent adverse effectsFetomaternal outcomeNeonatal complicationsPregnancy performanceFetal outcomesNeonatal outcomesCreatinine clearanceBlood pressureDistress syndromeEarly pregnancyNeonatal careNephrotic syndromeFetal surveillanceBirth weightMaternal healthNatural coursePatterns of invasive melanoma in the connecticut tumor registry. Is the long‐term increase real?
Roush G, Schymura M, Holford T. Patterns of invasive melanoma in the connecticut tumor registry. Is the long‐term increase real? Cancer 1988, 61: 2586-2595. PMID: 3365679, DOI: 10.1002/1097-0142(19880615)61:12<2586::aid-cncr2820611233>3.0.co;2-2.Peer-Reviewed Original ResearchConceptsConnecticut Tumor RegistryProportion of casesIncidence rateTumor RegistryCase ascertainmentBirth cohortPopulation-based incidence dataInvasive cutaneous malignant melanomaPeriod of diagnosisCutaneous malignant melanomaPatterns of changeMalignant melanomaInvasive melanomaCohort curvesAge groupsDisease riskAnalysis of ageIncidence dataMelanomaRegistryCohortDiagnosisArtifactual changesAscertainmentLong-term increase
1985
Risk for cutaneous melanoma in recent Connecticut birth cohorts.
Roush G, Schymura M, Holford T. Risk for cutaneous melanoma in recent Connecticut birth cohorts. American Journal Of Public Health 1985, 75: 679-82. PMID: 4003640, PMCID: PMC1646211, DOI: 10.2105/ajph.75.6.679.Peer-Reviewed Original ResearchMenarcheal age and habitual miscarriage: evidence for an association
Bracken M, Bryce-Buchanan C, Stilten R, Holford T. Menarcheal age and habitual miscarriage: evidence for an association. Annals Of Human Biology 1985, 12: 525-531. PMID: 4091507, DOI: 10.1080/03014468500008101.Peer-Reviewed Original Research
1982
Effects of cigarette smoking, alcohol, coffee and tea consumption on preterm delivery
Berkowitz G, Holford T, Berkowitz R. Effects of cigarette smoking, alcohol, coffee and tea consumption on preterm delivery. Early Human Development 1982, 7: 239-250. PMID: 7160334, DOI: 10.1016/0378-3782(82)90086-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlcohol DrinkingCoffeeFemaleHumansObstetric Labor, PrematurePregnancyRiskSmokingTeaConceptsPreterm deliveryMothers of singletonsTea consumptionTerm infantsCigarette smokingRisk factorsYale-New Haven HospitalHeavy tea consumptionPossible risk factorsCase-control studyHeavy alcohol consumptionPreterm infantsMore cigarettesMore cupsCoffee drinkingAlcohol consumptionInfantsSmokingSignificant relationWomenDeliveryMothersRiskDaysSingletons
1976
A stochastic model for the analysis of age-specific prevalence curves in schistosomiasis
Holford T, Hardy R. A stochastic model for the analysis of age-specific prevalence curves in schistosomiasis. Journal Of Clinical Epidemiology 1976, 29: 445-458. PMID: 939800, DOI: 10.1016/0021-9681(76)90085-0.Peer-Reviewed Original Research