2000
Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk
Holford T, Zheng T, Mayne S, Zahm S, Tessari J, Boyle P. Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk. International Journal Of Epidemiology 2000, 29: 975-982. PMID: 11101537, DOI: 10.1093/ije/29.6.975.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskProtective effectBreast adipose tissue samplesYale-New Haven HospitalBreast-related surgeryAdipose tissue samplesStandardized questionnaireHealth concernCYP2B inducersAdverse effectsLogistic ridge regressionTissue samplesExposure levelsSignificant differencesMajor environmental health concernRiskEnvironmental health concernsPCB congenersDioxin-like congenersJoint effectsPatientsStatistical analysisSurgeryRegressionOxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer.
Zheng T, Holford T, Tessari J, Mayne S, Zahm S, Owens P, Zhang B, Ward B, Carter D, Zhang Y, Zhang W, Dubrow R, Boyle P. Oxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer. Journal Of Cancer Epidemiology And Prevention 2000, 5: 153-60. PMID: 11051111.Peer-Reviewed Original ResearchConceptsAdipose tissue levelsBreast cancer riskFemale breast cancerBreast adipose tissueBreast cancerRisk factorsOdds ratioAdipose tissueBenign breast disease controlsFemale breast cancer riskPrimary breast cancer patientsCovariate-adjusted odds ratioEnvironmental exposuresProgesterone receptor statusBreast cancer patientsRecent epidemiological studiesMenopausal statusReceptor statusHighest quartileEpidemiological studiesCancerMajor metaboliteRiskStructured questionnaireOverall significant impact
1999
DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer
Zheng T, Holford T, Mayne S, Ward B, Carter D, Ownes P, Dubrow R, Zahm S, Boyle P, Archibeque S, Tessari J. DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer. American Journal Of Epidemiology 1999, 150: 453-458. PMID: 10472944, DOI: 10.1093/oxfordjournals.aje.a010033.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast adipose tissueTissue levelsCancer riskAdipose tissueBenign breast disease controlsIncident breast cancer casesYale-New Haven HospitalBreast-related surgeryAdipose tissue levelsFemale breast cancerCase-control studyBreast cancer casesMean tissue levelsLogistic regression modelsRank sum testHighest quartileSurgical specimenDichlorodiphenyltrichloroethane (DDT) exposureOdds ratioBreast cancerCancer casesDisease controlSum testMean levels
1984
Exogenous hormone use and fibrocystic breast disease by histopathologic component
Berkowitz G, Kelsey J, Livolsi V, Merino M, Holford T, Hildreth N, Ort S, O'Connor T, White C. Exogenous hormone use and fibrocystic breast disease by histopathologic component. International Journal Of Cancer 1984, 34: 443-449. PMID: 6490201, DOI: 10.1002/ijc.2910340403.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseEstrogen replacement therapyBreast diseaseGross cystsReplacement therapyHospital-based case-control studyExogenous hormone useOral contraceptive usePost-menopausal womenCase-control studyPostmenopausal womenPremenopausal womenHormone useOral contraceptivesEpithelial atypiaControl womenPapillary hyperplasiaBiopsy specimensFibrocystic lesionsSurgical conditionsContraceptive useHistopathologic componentsWomenIncreased occurrenceDisease
1978
Fibrocystic Breast Disease in Oral-Contraceptive Users — A Histopathological Evaluation of Epithelial Atypia
Livolsi V, Stadel B, Kelsey J, Holford T, White C. Fibrocystic Breast Disease in Oral-Contraceptive Users — A Histopathological Evaluation of Epithelial Atypia. New England Journal Of Medicine 1978, 299: 381-385. PMID: 566853, DOI: 10.1056/nejm197808242990803.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseOral contraceptivesLong-term usersBreast cancerEpithelial atypiaFibrocystic diseaseBreast diseaseOral contraceptive usersLong-term usePremenopausal womenHistopathological evaluationHistologic standpointCystic diseasePremalignant formsEpidemiological studiesDiseaseContraceptivesAtypiaCancerWomenSignificant differencesNontakersIncidence