2018
A spatiotemporal back‐calculation approach to estimate cancer incidence measures
Nautiyal N, Holford TR. A spatiotemporal back‐calculation approach to estimate cancer incidence measures. Statistics In Medicine 2018, 37: 4472-4489. PMID: 30155939, DOI: 10.1002/sim.7934.Peer-Reviewed Original Research
2003
Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk
Zheng T, Holford T, Zahm S, Owens P, Boyle P, Zhang Y, Zhang B, Wise J, Stephenson L, Ali-Osman F. Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk. British Journal Of Cancer 2003, 88: 58-62. PMID: 12556960, PMCID: PMC2376773, DOI: 10.1038/sj.bjc.6600708.Peer-Reviewed Original ResearchConceptsBreast cancer riskGSTT1 null genotypeCancer riskAlcohol consumptionGST genotypesBreast cancerPostmenopausal womenGenetic polymorphismsIncident breast cancer patientsGlutathione S-transferase M1Breast cancer patientsT1 genetic polymorphismsCase-control studyGSTT1 genetic polymorphismsGlutathione S-transferaseS-transferase M1Cancer patientsEffect modificationGSTM1 genotypeHigh riskNew Haven CountyYounger ageCancerWomenRisk
2002
Use of hair colouring products and breast cancer risk a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Boyle P, Zhang B, Zhang Y, Zahm S. Use of hair colouring products and breast cancer risk a case–control study in Connecticut. European Journal Of Cancer 2002, 38: 1647-1652. PMID: 12142056, DOI: 10.1016/s0959-8049(02)00138-7.Peer-Reviewed Original ResearchRadiation exposure from diagnostic and therapeutic treatments and risk of breast cancer
Zheng T, Holford TR, Mayne ST, Luo J, Owens PH, Zhang B, Zhang W, Zhang Y. Radiation exposure from diagnostic and therapeutic treatments and risk of breast cancer. European Journal Of Cancer Prevention 2002, 11: 229-235. PMID: 12131656, DOI: 10.1097/00008469-200206000-00006.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreast NeoplasmsCase-Control StudiesFemaleHumansNeoplasms, Radiation-InducedRisk FactorsConceptsBreast cancerTherapeutic radiation treatmentRadiation treatmentOdds ratioTherapeutic radiationSkin problemsBreast cancer risk factorsRadiation exposureCancer risk factorsBreast cancer riskCase-control studyDiagnostic X-ray exposurePostmenopausal womenRisk factorsCancer riskHigh riskYounger ageTherapeutic treatmentCancerDiagnostic X-raysPerson interviewsTreatmentX-ray exposureRiskStructured questionnaireA case-control study of occupation and breast-cancer risk in Connecticut.
Zheng T, Holford T, Taylor Mayne S, Luo J, Hansen Owens P, Hoar Zahm S, Zhang B, Zhang Y, Zhang W, Jiang Y, Boyle P. A case-control study of occupation and breast-cancer risk in Connecticut. Journal Of Cancer Epidemiology And Prevention 2002, 7: 3-11. PMID: 12369604, DOI: 10.1080/14766650252962621.Peer-Reviewed Original Research
2001
Restricted activity among community-living older persons: incidence, precipitants, and health care utilization.
Gill T, Desai M, Gahbauer E, Holford T, Williams C. Restricted activity among community-living older persons: incidence, precipitants, and health care utilization. Annals Of Internal Medicine 2001, 135: 313-21. PMID: 11529694, DOI: 10.7326/0003-4819-135-5-200109040-00007.Peer-Reviewed Original ResearchConceptsCommunity-living older personsHealth care utilizationCare utilizationRestricted activityOlder personsProspective cohort studyEmergency department visitsMonthly telephone interviewsPhysician office visitsLarge health planYears of ageHealth-related problemsCohort studyDepartment visitsHospital admissionOffice visitsFunctional statusMedical attentionHigh riskHealth plansTelephone interviewsMonthsConsecutive monthsEpisodesDisabilityThe Natural History of Periodontal Disease in Man. Risk Factors for Progression of Attachment Loss in Individuals Receiving No Oral Health Care
Neely A, Holford T, Löe H, Ånerud Å, Boysen H. The Natural History of Periodontal Disease in Man. Risk Factors for Progression of Attachment Loss in Individuals Receiving No Oral Health Care. Journal Of Periodontology 2001, 72: 1006-1015. PMID: 11525431, DOI: 10.1902/jop.2001.72.8.1006.Peer-Reviewed Original ResearchConceptsHistory of smokingAttachment lossPeriodontal attachment lossGingival indexCalculus indexPlaque indexRisk factorsPeriodontal diseaseNatural historyMean attachment lossOral health assessmentProfessional dental careOral health careFinal adjusted modelPotential risk factorsMesio-buccal surfaceThird molar teethBetel nut useAbsence of teethCaries indexDental careAttachment levelAdjusted modelNut useMolar teeth1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies
Laden F, Collman G, Iwamoto K, Alberg A, Berkowitz G, Freudenheim J, Hankinson S, Helzlsouer K, Holford T, Huang H, Moysich K, Tessari J, Wolff M, Zheng T, Hunter D. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies. Journal Of The National Cancer Institute 2001, 93: 768-775. PMID: 11353787, DOI: 10.1093/jnci/93.10.768.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerCancer riskRisk factorsEffect modificationOdds ratioBreast cancer risk factorsElevated breast cancer riskAssess effect modificationBody mass indexCancer risk factorsConfidence intervalsPooled odds ratioPotential risk factorsPlasma/serum concentrationsAssociation of levelsLarge U.S. studiesRandom-effects modelCase patientsMass indexMiddle tertileFifth quintilePooled analysisControl subjectsSerum concentrations
2000
Food group intake and the risk of oral epithelial dysplasia in a United States population
Morse D, Pendrys D, Katz R, Holford T, Krutchkoff D, Eisenberg E, Kosis D, Kerpel S, Freedman P, Mayne S. Food group intake and the risk of oral epithelial dysplasia in a United States population. Cancer Causes & Control 2000, 11: 713-720. PMID: 11065008, DOI: 10.1023/a:1008943904085.Peer-Reviewed Original ResearchConceptsOral epithelial dysplasiaFood group intakesGroup intakesEpithelial dysplasiaOdds ratio point estimateDairy food intakeFood frequency questionnaireOral Pathology LaboratoryCase-control studyRole of dietBread/cerealsConsumption of fruitsAspects of dietUnited States populationIncident casesOral cancerOral carcinogenesisHistopathologic diagnosisLate effectsFood intakeAppointment datePotential covariatesLogistic regressionTelephone interviewsPathology laboratoryBreast Cancer Risk Associated with Congeners of Polychlorinated Biphenyls
Zheng T, Holford TR, Tessari J, Mayne ST, Owens PH, Ward B, Carter D, Boyle P, Dubrow R, Archibeque-Engle S, Zahm SH. Breast Cancer Risk Associated with Congeners of Polychlorinated Biphenyls. American Journal Of Epidemiology 2000, 152: 50-58. PMID: 10901329, DOI: 10.1093/aje/152.1.50.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskCovariate-adjusted odds ratioBreast Cancer Risk AssociatedCase-control studyBreast cancer casesBreast adipose tissueMean tissue levelsCancer Risk AssociatedLowest tertileThird tertileBreast diseaseOdds ratioBreast cancerCancer casesConnecticut womenAdipose tissueFurther stratificationSignificant associationStudy participantsTissue levelsNonhormonal activitiesBody levelEnvironmental exposuresSpecific PCB congenersPulse pressure and risk for myocardial infarction and heart failure in the elderly
Vaccarino V, Holford T, Krumholz H. Pulse pressure and risk for myocardial infarction and heart failure in the elderly. Journal Of The American College Of Cardiology 2000, 36: 130-138. PMID: 10898424, DOI: 10.1016/s0735-1097(00)00687-2.Peer-Reviewed Original ResearchConceptsCongestive heart failureCoronary heart diseaseSystolic blood pressureCardiovascular end pointsDiastolic blood pressurePulse pressureBlood pressureEnd pointHeart failureIndependent predictorsOverall mortalityIncidence of CHFIncidence of CHDEffect of PPElevated systolic blood pressureCurrent hypertension guidelinesIncident CHF eventsCHD risk factorsCurrent medication useIncident CHD eventsPowerful independent predictorBlood pressure parametersBlood pressure variablesElevated pulse pressureDiastolic hypertensionExposure to Electromagnetic Fields from Use of Electric Blankets and Other In-Home Electrical Appliances and Breast Cancer Risk
Zheng T, Holford T, Mayne S, Owens P, Zhang B, Boyle P, Carter D, Ward B, Zhang Y, Zahm S. Exposure to Electromagnetic Fields from Use of Electric Blankets and Other In-Home Electrical Appliances and Breast Cancer Risk. American Journal Of Epidemiology 2000, 151: 1103-1111. PMID: 10873135, DOI: 10.1093/oxfordjournals.aje.a010154.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskOdds ratioAge frequency-matched controlsIncident breast cancer patientsElectric blanketFrequency-matched controlsAdjusted odds ratioBreast cancer patientsEstrogen receptor statusFemale breast cancerCase-control studyDuration of useReceptor statusCancer patientsNever usersBreast cancerStudy interviewersRegular useLifetime useRiskStructured questionnaireExposureTotalOxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer.
Zheng T, Holford T, Tessari J, Mayne S, Zahm S, Owens P, Zhang B, Ward B, Carter D, Zhang Y, Zhang W, Dubrow R, Boyle P. Oxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer. Journal Of Cancer Epidemiology And Prevention 2000, 5: 153-60. PMID: 11051111.Peer-Reviewed Original ResearchConceptsAdipose tissue levelsBreast cancer riskFemale breast cancerBreast adipose tissueBreast cancerRisk factorsOdds ratioAdipose tissueBenign breast disease controlsFemale breast cancer riskPrimary breast cancer patientsCovariate-adjusted odds ratioEnvironmental exposuresProgesterone receptor statusBreast cancer patientsRecent epidemiological studiesMenopausal statusReceptor statusHighest quartileEpidemiological studiesCancerMajor metaboliteRiskStructured questionnaireOverall significant impact
1999
DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer
Zheng T, Holford T, Mayne S, Ward B, Carter D, Ownes P, Dubrow R, Zahm S, Boyle P, Archibeque S, Tessari J. DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer. American Journal Of Epidemiology 1999, 150: 453-458. PMID: 10472944, DOI: 10.1093/oxfordjournals.aje.a010033.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast adipose tissueTissue levelsCancer riskAdipose tissueBenign breast disease controlsIncident breast cancer casesYale-New Haven HospitalBreast-related surgeryAdipose tissue levelsFemale breast cancerCase-control studyBreast cancer casesMean tissue levelsLogistic regression modelsRank sum testHighest quartileSurgical specimenDichlorodiphenyltrichloroethane (DDT) exposureOdds ratioBreast cancerCancer casesDisease controlSum testMean levelsA Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
Inouye S, Bogardus S, Charpentier P, Leo-Summers L, Acampora D, Holford T, Cooney L. A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients. New England Journal Of Medicine 1999, 340: 669-676. PMID: 10053175, DOI: 10.1056/nejm199903043400901.Peer-Reviewed Original ResearchConceptsSeverity of deliriumRisk factorsCognitive impairmentRecurrence rateIntervention groupRisk factor intervention strategyHearing impairmentVisual impairmentHospitalized Older PatientsPatients 70 yearsPrevention of deliriumUsual care unitsUsual care groupGeneral medicine serviceEffective treatment strategiesDuration of episodesPrevent DeliriumOlder patientsRate of usePrimary outcomeSleep medicationPoor outcomePrimary preventionPatient's deliriumTeaching hospital
1998
Spontaneous Abortion and Exposure to Electric Blankets and Heated Water Beds
Belanger K, Leaderer B, Hellenbrand K, Holford T, McSharry J, Power M, Bracken M. Spontaneous Abortion and Exposure to Electric Blankets and Heated Water Beds. Epidemiology 1998, 9: 36-42. PMID: 9430266, DOI: 10.1097/00001648-199801000-00009.Peer-Reviewed Original ResearchConceptsElectric blanket useSpontaneous abortionPregnancy lossBlanket useEarly pregnancy lossHeated water bedsTime of conceptionMonth of conceptionWire code categoriesWeeks' gestationProspective studyEarly pregnancyUnadjusted analysesBed useGreater riskPregnancyAbortionDose responseWomenRiskElectric bedElectric blanketExposureSlight increaseGestationSeizures with Fever After Unprovoked Seizures: An Analysis in Children Followed from the Time of a First Febrile Seizure
Berg A, Darefsky A, Holford T, Shinnar S. Seizures with Fever After Unprovoked Seizures: An Analysis in Children Followed from the Time of a First Febrile Seizure. Epilepsia 1998, 39: 77-80. PMID: 9578016, DOI: 10.1111/j.1528-1157.1998.tb01277.x.Peer-Reviewed Original ResearchConceptsFirst febrile seizureFebrile seizuresUnprovoked seizuresFurther seizuresFirst unprovoked seizureRecurrent febrile seizuresCox regression modelBenign febrile seizuresInfluence recurrenceTime-dependent covariatesProspective cohortSecond seizureTreatment decisionsFeverSeizuresSubstantial riskRate ratioYoung childrenChildrenOnsetRegression modelsSmall proportionRiskPredictorsRecurrence
1997
Statistical evaluation of the role of Helicobacter pylori in stress gastritis: Applications of splines and bootstrapping to the logistic model
Riester K, Peduzzi P, Holford T, Ellison R, Donta S. Statistical evaluation of the role of Helicobacter pylori in stress gastritis: Applications of splines and bootstrapping to the logistic model. Journal Of Clinical Epidemiology 1997, 50: 1273-1279. PMID: 9393383, DOI: 10.1016/s0895-4356(97)00180-7.Peer-Reviewed Original ResearchConceptsStress gastritisH. pyloriHelicobacter pyloriIntensive care unit populationIntensive care unitImmunoglobulin A (IgA) concentrationsCharacteristic curve analysisCare unitGastric ulcerRisk factorsUnit populationGastritisA concentrationsPyloriCurve analysisLogistic modelImportant predictorCausal natureSpline modelUlcersMouthwash use and dentures in relation to oral epithelial dysplasia
Morse D, Katz R, Pendrys D, Holford T, Krutchkoff D, Eisenberg E, Kosis D, Kerpel S, Freedman P, Mayne S. Mouthwash use and dentures in relation to oral epithelial dysplasia. Oral Oncology 1997, 33: 338-343. PMID: 9415333, DOI: 10.1016/s1368-8375(97)00019-5.Peer-Reviewed Original ResearchConceptsOral epithelial dysplasiaMouthwash useEpithelial dysplasiaDenture useOdds ratioYears of dentureOral Pathology LaboratoryCase-control studyConditional logistic regressionCase-control pairsOED casesAppointment datePotential associationLogistic regressionTelephone interviewsExposure informationPathology laboratoryConfidence intervalsDysplasiaDenturesMouthwashRiskSmokingYearsSurgeonsAre cancers of the salivary gland increasing? Experience from Connecticut, USA.
Zheng T, Holford T, Chen Y, Ward B, Liu W, Flannery J, Boyle P. Are cancers of the salivary gland increasing? Experience from Connecticut, USA. International Journal Of Epidemiology 1997, 26: 264-271. PMID: 9169160, DOI: 10.1093/ije/26.2.264.Peer-Reviewed Original ResearchConceptsSalivary glandsRelative riskBirth cohortRare squamous cell carcinomaEpstein-Barr virus infectionConnecticut Tumor Registry dataTime trendsComparable relative riskSquamous cell carcinomaTumor registry dataAge group 40Salivary gland cancerYears of ageOlder age groupsRecent birth cohortsObserved time trendsPrior cancerLower gumCell carcinomaGland cancerIncidence rateRisk factorsUnivariate analysisCancer sitesRegistry data