2000
Pulse pressure and risk for myocardial infarction and heart failure in the elderly
Vaccarino V, Holford T, Krumholz H. Pulse pressure and risk for myocardial infarction and heart failure in the elderly. Journal Of The American College Of Cardiology 2000, 36: 130-138. PMID: 10898424, DOI: 10.1016/s0735-1097(00)00687-2.Peer-Reviewed Original ResearchConceptsCongestive heart failureCoronary heart diseaseSystolic blood pressureCardiovascular end pointsDiastolic blood pressurePulse pressureBlood pressureEnd pointHeart failureIndependent predictorsOverall mortalityIncidence of CHFIncidence of CHDEffect of PPElevated systolic blood pressureCurrent hypertension guidelinesIncident CHF eventsCHD risk factorsCurrent medication useIncident CHD eventsPowerful independent predictorBlood pressure parametersBlood pressure variablesElevated pulse pressureDiastolic hypertension
1998
Seizures with Fever After Unprovoked Seizures: An Analysis in Children Followed from the Time of a First Febrile Seizure
Berg A, Darefsky A, Holford T, Shinnar S. Seizures with Fever After Unprovoked Seizures: An Analysis in Children Followed from the Time of a First Febrile Seizure. Epilepsia 1998, 39: 77-80. PMID: 9578016, DOI: 10.1111/j.1528-1157.1998.tb01277.x.Peer-Reviewed Original ResearchConceptsFirst febrile seizureFebrile seizuresUnprovoked seizuresFurther seizuresFirst unprovoked seizureRecurrent febrile seizuresCox regression modelBenign febrile seizuresInfluence recurrenceTime-dependent covariatesProspective cohortSecond seizureTreatment decisionsFeverSeizuresSubstantial riskRate ratioYoung childrenChildrenOnsetRegression modelsSmall proportionRiskPredictorsRecurrence
1987
Loss of myeloid differentiation antigens precedes blastic transformation in chronic myelogenous leukemia.
Todd M, Waldron J, Jennings T, Rome L, Markowitz S, Holford T, Gardner J, Wolak J, Malech H. Loss of myeloid differentiation antigens precedes blastic transformation in chronic myelogenous leukemia. Blood 1987, 70: 122-31. PMID: 2439147, DOI: 10.1182/blood.v70.1.122.bloodjournal701122.Peer-Reviewed Original ResearchConceptsBone marrow biopsy samplesBone marrow biopsy specimensBone marrow biopsyAntigen-positive cellsMarrow biopsy specimensChronic myelogenous leukemiaBlast crisisBiopsy specimensBone marrow cellsBiopsy samplesBlast transformationMyeloid antigensChronic phaseMarrow biopsyDisease progressionMyelogenous leukemiaMarrow cellsImpending blast crisisMyeloid differentiation antigensHuman neutrophil antigensPatient 1Neutrophil antigensBlastic crisisBlastic transformationIndirect immunoperoxidase
1986
Prognostic indicators in diffuse large-cell (histiocytic) lymphoma
Todd M, Portlock C, Farber L, Holford T, Bertino J. Prognostic indicators in diffuse large-cell (histiocytic) lymphoma. International Journal Of Radiation Oncology • Biology • Physics 1986, 12: 593-601. PMID: 2422144, DOI: 10.1016/0360-3016(86)90068-4.Peer-Reviewed Original ResearchConceptsDiffuse large cell lymphomaLarge cell lymphomaPrognostic groupsSystemic symptomsPrognostic indicatorAnn Arbor staging systemBone marrow involvementBulk of diseaseLactic dehydrogenaseDiffuse histiocytic lymphomaAnn Arbor classificationStage of diseaseReliable prognostic indicatorChemotherapy clinical trialsLukes-Collins classificationSerum lactic dehydrogenaseMarrow involvementOverall survivalCombination chemotherapyPrognostic factorsDisease involvementPathological criteriaStaging systemSpecific therapyHistiocytic lymphoma
1982
CLINICAL CHARACTERISTICS AND CIGARETTE SMOKING IN RELATION TO PROGNOSIS OF ANGINA PECTORIS IN FRAMINGHAM
HUBERT H, HOLFORD T, KANNEL W. CLINICAL CHARACTERISTICS AND CIGARETTE SMOKING IN RELATION TO PROGNOSIS OF ANGINA PECTORIS IN FRAMINGHAM. American Journal Of Epidemiology 1982, 115: 231-242. PMID: 7058782, DOI: 10.1093/oxfordjournals.aje.a113295.Peer-Reviewed Original ResearchConceptsAngina pectorisBlood pressureAngina onsetElectrocardiographic findingsUncomplicated angina pectorisCoronary risk factorsFuture coronary eventsElevated blood pressurePowerful independent predictorCigarette smoking habitsLong-term prognosisSystolic blood pressureLong-term followYears of ageLack of associationCoronary eventsCoronary riskBaseline characteristicsSymptom onsetYounger patientsIndependent predictorsPrognostic advantageSmoking habitsAbnormal electrocardiogramCigarette smoking